mt-Nd6 NADH dehydrogenase 6, mitochondrial [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: mt-Nd6provided by MGI
Official Full Name: NADH dehydrogenase 6, mitochondrialprovided by MGI
Primary source: MGI:MGI:102495
See related: AllianceGenome:MGI:102495
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus (strain: C57BL/6J)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ND6
Summary: Enables NADH dehydrogenase (ubiquinone) activity. Involved in mitochondrial electron transport, NADH to ubiquinone and mitochondrial respiratory chain complex I assembly. Located in mitochondrion. Is expressed in brain; early conceptus; and secondary oocyte. Used to study Leber hereditary optic neuropathy and lactic acidosis. Human ortholog(s) of this gene implicated in Leber hereditary optic neuropathy; Leigh disease; and spinal muscular atrophy with lower extremity predominant 2B. Orthologous to human MT-ND6 (mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	MT (non-nuclear)	NC_005089.1 (13552..14070, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	MT (non-nuclear)	NC_005089.1 (13552..14070, complement)

Chromosome MT - NC_005089.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that expression of ND6 in adipose tissue can be regulated by dietary factors; here, expression of ND6 in mitochondria of white adipose tissue is down-regulated in obesity caused by high-fat diet.
Title: High-fat diet decreases energy expenditure and expression of genes controlling lipid metabolism, mitochondrial function and skeletal system development in the adipose tissue, along with increased expression of extracellular matrix remodelling- and inflammation-related genes.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically and radiation induced (1) 1 citation
Endonuclease-mediated (1)
Spontaneous (5) 1 citation

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH136450 (e-PCR)
- UniSTS:210436

RH136205 (e-PCR)
- UniSTS:210200

RH136495 (e-PCR)
- UniSTS:210478

PMC85197P1 (e-PCR)
- UniSTS:273467

RH136257 (e-PCR)
- UniSTS:210250

mt-Nd6 (e-PCR), detects polymorphism
- UniSTS:496723

RH136536 (e-PCR)
- UniSTS:210518

RH136271 (e-PCR)
- UniSTS:210264

RH136274 (e-PCR)
- UniSTS:210267

RH136546 (e-PCR)
- UniSTS:210528

RH136285 (e-PCR)
- UniSTS:210278

RH136633 (e-PCR)
- UniSTS:210613

RH136370 (e-PCR)
- UniSTS:210360

RH136382 (e-PCR)
- UniSTS:210372

Homology

Orthologs from OrthoDB

URF6

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables NADH dehydrogenase (ubiquinone) activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables NADH dehydrogenase (ubiquinone) activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in aerobic respiration	NAS Non-traceable Author Statement more info	PubMed
involved_in mitochondrial electron transport, NADH to ubiquinone	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial electron transport, NADH to ubiquinone	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial respiratory chain complex I assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial respiratory chain complex I assembly	ISO Inferred from Sequence Orthology more info
involved_in proton motive force-driven mitochondrial ATP synthesis	NAS Non-traceable Author Statement more info	PubMed
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in response to cocaine	IEA Inferred from Electronic Annotation more info
involved_in response to hydrogen peroxide	IEA Inferred from Electronic Annotation more info
involved_in response to nicotine	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
part_of respiratory chain complex I	IDA Inferred from Direct Assay more info	PubMed
part_of respiratory chain complex I	ISO Inferred from Sequence Orthology more info