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nex-2 Annexin [ Caenorhabditis elegans ]

Gene ID: 176446, updated on 2-Nov-2024

Summary

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Official Symbol
nex-2
Official Full Name
Annexin
Primary source
WormBase:WBGene00003589
Locus tag
CELE_T07C4.9
See related
AllianceGenome:WB:WBGene00003589
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables heparan sulfate proteoglycan binding activity; heparin binding activity; and phospholipid binding activity. Predicted to be active in several cellular components, including nucleus; plasma membrane; and vesicle membrane. Is expressed in pharynx. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 23; autoimmune disease of the nervous system; inclusion body myopathy and brain white matter abnormalities; myocardial infarction; and systemic scleroderma. Orthologous to several human genes including ANXA7 (annexin A7). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See nex-2 in Genome Data Viewer
Location:
chromosome: III
Exon count:
5
Sequence:
Chromosome: III; NC_003281.10 (10325626..10330422, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4 Neighboring gene Short coiled-coil protein;Short coiled-coil protein homolog Neighboring gene Spindle assembly abnormal protein 7 Neighboring gene COMM domain-containing protein Neighboring gene JmjC domain-containing protein Neighboring gene ncRNA Neighboring gene Succinate dehydrogenase cytochrome b560 subunit, mitochondrial

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Centriolar SAS-7 acts upstream of SPD-2 to regulate centriole assembly and pericentriolar material formation. Sugioka K, et al. Elife, 2017 Jan 16. PMID 28092264, Free PMC Article
  2. Identification, localization, and functional implications of an abundant nematode annexin. Creutz CE, et al. J Cell Biol, 1996 Mar. PMID 8601586, Free PMC Article
  3. Transcription, biochemistry and localization of nematode annexins. Daigle SN, et al. J Cell Sci, 1999 Jun. PMID 10341209
  4. Ligand-binding activity and expression profile of annexins in Caenorhabditis elegans. Nishioka S, et al. J Biochem, 2007 Jan. PMID 17169974
  5. Expanded genetic screening in Caenorhabditis elegans identifies new regulators and an inhibitory role for NAD(+) in axon regeneration. Kim KW, et al. Elife, 2018 Nov 21. PMID 30461420, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables 1-phosphatidylinositol binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-dependent phospholipid binding IEA
Inferred from Electronic Annotation
more info
  
enables heparan sulfate proteoglycan binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables heparin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylethanolamine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylethanolamine binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylserine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylserine binding IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Annexin
NP_001022755.1
  • Confirmed by transcript evidence
NP_001022756.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    10325626..10330422 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001027585.6 → NP_001022756.1  Annexin [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022756.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JMT5
    Conserved Domains (1) summary
    pfam00191
    Location:225 → 290
    Annexin; Annexin

  2. NM_001027584.7 → NP_001022755.1  Annexin [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022755.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q27512
    Conserved Domains (1) summary
    pfam00191
    Location:267 → 332
    Annexin; Annexin
Nucleotide Protein
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