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sma-2 Dwarfin sma-2;MH2 domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 176229, updated on 2-Nov-2024

Summary

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Official Symbol
sma-2
Official Full Name
Dwarfin sma-2;MH2 domain-containing protein
Primary source
WormBase:WBGene00004856
Locus tag
CELE_ZK370.2
See related
AllianceGenome:WB:WBGene00004856
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; I-SMAD binding activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including male anatomical structure morphogenesis; nematode pharynx development; and positive regulation of nematode male tail tip morphogenesis. Predicted to be located in cytoplasm and nucleus. Predicted to be part of heteromeric SMAD protein complex. Is expressed in head; pharynx; reproductive system; and seam cell. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome (multiple); Lynch syndrome; female reproductive organ cancer (multiple); pancreatic cancer; and primary pulmonary hypertension. Orthologous to several human genes including SMAD9 (SMAD family member 9). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See sma-2 in Genome Data Viewer
Location:
chromosome: III
Exon count:
11
Sequence:
Chromosome: III; NC_003281.10 (8749680..8757089)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene DUF19 domain-containing protein Neighboring gene UDP-galactose translocator 1 Neighboring gene Mitochondrial import receptor subunit tomm-70 Neighboring gene ncRNA Neighboring gene 5'-AMP-activated protein kinase catalytic subunit alpha-1 Neighboring gene Chondroitin sulfate synthase mig-22 Neighboring gene Single-stranded DNA-binding protein, mitochondrial

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Somatic polyploidization and cellular proliferation drive body size evolution in nematodes. Flemming AJ, et al. Proc Natl Acad Sci U S A, 2000 May 9. PMID 10805788, Free PMC Article
  2. Single mammalian cells compensate for differences in cellular volume and DNA copy number through independent global transcriptional mechanisms. Padovan-Merhar O, et al. Mol Cell, 2015 Apr 16. PMID 25866248, Free PMC Article
  3. C. elegans DAF-16/FOXO interacts with TGF-ß/BMP signaling to induce germline tumor formation via mTORC1 activation. Qi W, et al. PLoS Genet, 2017 May. PMID 28549065, Free PMC Article
  4. From receptor to nucleus: the Smad pathway. Baker JC, et al. Curr Opin Genet Dev, 1997 Aug. PMID 9309176
  5. Identification of transforming growth factor-beta- regulated genes in caenorhabditis elegans by differential hybridization of arrayed cDNAs. Mochii M, et al. Proc Natl Acad Sci U S A, 1999 Dec 21. PMID 10611331, Free PMC Article

See all (79) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Three Smad genes, sma-2, sma-3 and sma-4, are all required for signal transduction, suggesting that the functional complex could be a heterotrimer.
    Title: C-terminal mutants of C. elegans Smads reveal tissue-specific requirements for protein activation by TGF-beta signaling.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables I-SMAD binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in BMP signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in SMAD protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in anatomical structure morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nematode male tail mating organ morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nematode male tail tip morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nematode pharynx development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell growth IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of cell growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of multicellular organism growth IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of nematode male tail tip morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in post-embryonic development IEA
Inferred from Electronic Annotation
more info
  
involved_in post-embryonic development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of developmental process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of mesodermal cell fate specification IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of multicellular organismal process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of heteromeric SMAD protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Dwarfin sma-2;MH2 domain-containing protein
NP_001360602.1
  • Partially confirmed by transcript evidence
NP_001370321.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    8749680..8757089
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001382944.1 → NP_001370321.1  Dwarfin sma-2 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q02329, Q02330
    Conserved Domains (2) summary
    cd10495
    Location:222 → 405
    MH2_R-SMAD; C-terminal Mad Homology 2 (MH2) domain in receptor regulated SMADs
    cl00055
    Location:5 → 130
    MH1; N-terminal Mad Homology 1 (MH1) domain

  2. NM_001372636.2 → NP_001360602.1  MH2 domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A4V0IIJ7
    Conserved Domains (1) summary
    cd10495
    Location:68 → 251
    MH2_R-SMAD; C-terminal Mad Homology 2 (MH2) domain in receptor regulated SMADs
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q02330.2

Gene LinkOut

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