aco-2 putative aconitate hydratase, mitochondrial [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: aco-2
Official Full Name: putative aconitate hydratase, mitochondrial
Primary source: WormBase:WBGene00000041
Locus tag: CELE_F54H12.1
See related: AllianceGenome:WB:WBGene00000041
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable 4 iron, 4 sulfur cluster binding activity and aconitate hydratase activity. Predicted to be involved in tricarboxylic acid cycle. Located in mitochondrion. Is expressed widely. Human ortholog(s) of this gene implicated in infantile cerebellar-retinal degeneration and optic atrophy 9. Orthologous to human ACO2 (aconitase 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See aco-2 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 6

Sequence:: Chromosome: III; NC_003281.10 (7973717..7977355)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F54H12.6 (e-PCR)
- UniSTS:320991

F54H12.1 (e-PCR)
- UniSTS:311799

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables 4 iron, 4 sulfur cluster binding	IBA Inferred from Biological aspect of Ancestor more info
enables 4 iron, 4 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables aconitate hydratase activity	IBA Inferred from Biological aspect of Ancestor more info
enables aconitate hydratase activity	IEA Inferred from Electronic Annotation more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in tricarboxylic acid cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in tricarboxylic acid cycle	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: putative aconitate hydratase, mitochondrial

NP_498738.2

Confirmed by transcript evidence

NP_741235.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

7973717..7977355

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_171200.5 → NP_741235.1 putative aconitate hydratase, mitochondrial [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_741235.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P34455, Q8IG17, Q8WQF0

Conserved Domains (3) summary

cd01584
Location:92 → 502

AcnA_Mitochondrial; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle

cd01578
Location:581 → 729

AcnA_Mitochon_Swivel; Mitochondrial aconitase A swivel domain. Aconitase (also known as aconitate hydratase and citrate hydro-lyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes ...

TIGR01340
Location:42 → 769

aconitase_mito; aconitate hydratase, mitochondrial
NM_066337.8 → NP_498738.2 putative aconitate hydratase, mitochondrial [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_498738.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P34455

Conserved Domains (3) summary

cd01584
Location:1 → 408

AcnA_Mitochondrial; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle

cd01578
Location:487 → 635

AcnA_Mitochon_Swivel; Mitochondrial aconitase A swivel domain. Aconitase (also known as aconitate hydratase and citrate hydro-lyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes ...

TIGR01340
Location:1 → 675

aconitase_mito; aconitate hydratase, mitochondrial