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let-767 Very-long-chain 3-oxooacyl-coA reductase let-767 [ Caenorhabditis elegans ]

Gene ID: 175895, updated on 18-Sep-2024

Summary

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Official Symbol
let-767
Official Full Name
Very-long-chain 3-oxooacyl-coA reductase let-767
Primary source
WormBase:WBGene00002891
Locus tag
CELE_C56G2.6
See related
AllianceGenome:WB:WBGene00002891
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables long-chain-fatty-acyl-CoA reductase activity and testosterone dehydrogenase [NAD(P)] activity. Involved in several processes, including cellular hormone metabolic process; female genitalia development; and long-chain fatty acid biosynthetic process. Located in apical cortex and endoplasmic reticulum. Is expressed in hypodermis; intestine; and pharynx. Human ortholog(s) of this gene implicated in 17-beta hydroxysteroid dehydrogenase 3 deficiency and disorder of sexual development. Orthologous to several human genes including HSD17B12 (hydroxysteroid 17-beta dehydrogenase 12). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See let-767 in Genome Data Viewer
Location:
chromosome: III
Exon count:
5
Sequence:
Chromosome: III; NC_003281.10 (6338509..6339955, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Proteasomal ubiquitin receptor ADRM1;Proteasomal ubiquitin receptor ADRM1 homolog Neighboring gene DUF4604 domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Enzymatic preparation of Crassostrea oyster peptides and their promoting effect on male hormone production. Zhang W, et al. J Ethnopharmacol, 2021 Jan 10. PMID 32918991
  2. Caenorhabditis elegans LET-767 is able to metabolize androgens and estrogens and likely shares common ancestor with human types 3 and 12 17beta-hydroxysteroid dehydrogenases. Desnoyers S, et al. J Endocrinol, 2007 Nov. PMID 17951538
  3. The sterol modifying enzyme LET-767 is essential for growth, reproduction and development in Caenorhabditis elegans. Kuervers LM, et al. Mol Genet Genomics, 2003 Nov. PMID 12905072
  4. LET-767 is required for the production of branched chain and long chain fatty acids in Caenorhabditis elegans. Entchev EV, et al. J Biol Chem, 2008 Jun 20. PMID 18390550
  5. Interpreting a sequenced genome: toward a cosmid transgenic library of Caenorhabditis elegans. Janke DL, et al. Genome Res, 1997 Oct. PMID 9331368

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LET-767 determines lipid droplet protein targeting and lipid homeostasis.
    Title: LET-767 determines lipid droplet protein targeting and lipid homeostasis.
  2. LET-767 is a major 3-ketoacyl-CoA reductase in C. elegans required for the bulk production of monomethyl branched and long chain fatty acids, and the developmental arrest in let-767 (RNAi) worms is caused by the deficiency of the former
    Title: LET-767 is required for the production of branched chain and long chain fatty acids in Caenorhabditis elegans.
  3. High conservation of the active site and amino acids responsible for enzymatic activity and substrate selectivity strongly suggests that LET-767 shares a common ancestor with human 17beta-HSD3 and 12.
    Title: Caenorhabditis elegans LET-767 is able to metabolize androgens and estrogens and likely shares common ancestor with human types 3 and 12 17beta-hydroxysteroid dehydrogenases.
  4. LET-767 modifies a sterol hormone that is required both for embryogenesis and for later stages of development.
    Title: The sterol modifying enzyme LET-767 is essential for growth, reproduction and development in Caenorhabditis elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables 17-beta-hydroxysteroid dehydrogenase (NADP+) activity IEA
Inferred from Electronic Annotation
more info
  
enables long-chain-fatty-acyl-CoA reductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables testosterone dehydrogenase [NAD(P)+] activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables very-long-chain 3-oxoacyl-CoA reductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in androgen metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in developmental process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment or maintenance of epithelial cell apical/basal polarity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in estrogen metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid elongation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in hormone metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in long-chain fatty acid biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in molting cycle, collagen and cuticulin-based cuticle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in steroid biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in steroid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in apical cortex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Very-long-chain 3-oxooacyl-coA reductase let-767
NP_001254935.1
  • Confirmed by transcript evidence
NP_001254936.1
  • Confirmed by transcript evidence
NP_001293606.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    6338509..6339955 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001306677.4 → NP_001293606.1  Very-long-chain 3-oxooacyl-coA reductase let-767 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293606.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    S6FCZ1
    Conserved Domains (2) summary
    cd05356
    Location:64 → 310
    17beta-HSD1_like_SDR_c; 17-beta-hydroxysteroid dehydrogenases (17beta-HSDs) types -1, -3, and -12, -like, classical (c) SDRs
    pfam00106
    Location:66 → 265
    adh_short; short chain dehydrogenase

  2. NM_001268007.4 → NP_001254936.1  Very-long-chain 3-oxooacyl-coA reductase let-767 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001254936.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    C1P622, Q09517, S6FCZ1
    Conserved Domains (2) summary
    cd05356
    Location:47 → 289
    17beta-HSD1_like_SDR_c; 17-beta-hydroxysteroid dehydrogenases (17beta-HSDs) types -1, -3, and -12, -like, classical (c) SDRs
    pfam00106
    Location:49 → 244
    adh_short; short chain dehydrogenase

  3. NM_001268006.3 → NP_001254935.1  Very-long-chain 3-oxooacyl-coA reductase let-767 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001254935.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C1P622
    Conserved Domains (2) summary
    cd05356
    Location:64 → 306
    17beta-HSD1_like_SDR_c; 17-beta-hydroxysteroid dehydrogenases (17beta-HSDs) types -1, -3, and -12, -like, classical (c) SDRs
    pfam00106
    Location:66 → 261
    adh_short; short chain dehydrogenase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q09517.2

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