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mvk-1 GHMP kinase C-terminal domain-containing protein;MeValonate Kinase;Mevalonate kinase [ Caenorhabditis elegans ]

Gene ID: 175863, updated on 18-Sep-2024

Summary

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Official Symbol
mvk-1
Official Full Name
GHMP kinase C-terminal domain-containing protein;MeValonate Kinase;Mevalonate kinase
Primary source
WormBase:WBGene00021534
Locus tag
CELE_Y42G9A.4
See related
AllianceGenome:WB:WBGene00021534
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable mevalonate kinase activity. Predicted to be involved in cholesterol biosynthetic process and isopentenyl diphosphate biosynthetic process, mevalonate pathway. Located in cytosol. Is expressed in body wall musculature; head; nervous system; and reproductive system. Human ortholog(s) of this gene implicated in lipid metabolism disorder; mevalonic aciduria; and porokeratosis. Orthologous to human MVK (mevalonate kinase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See mvk-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
14
Sequence:
Chromosome: III; NC_003281.10 (6124023..6136276, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene Glycylpeptide N-tetradecanoyltransferase;putative glycylpeptide N-tetradecanoyltransferase Neighboring gene Serine/threonine-protein kinase SULU Neighboring gene ABC transporter domain-containing protein Neighboring gene L domain-like protein;Leucine-rich repeat-containing protein 58 Neighboring gene Secreted protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A new definition for the consensus sequence of the peroxisome targeting signal type 2. Petriv OI, et al. J Mol Biol, 2004 Jul 30. PMID 15312767
  2. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article
  3. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
  4. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
  5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables mevalonate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mevalonate kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphotransferase activity, alcohol group as acceptor IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cholesterol biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in isopentenyl diphosphate biosynthetic process, mevalonate pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in isopentenyl diphosphate biosynthetic process, mevalonate pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in isoprenoid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
GHMP kinase C-terminal domain-containing protein;MeValonate Kinase;Mevalonate kinase
NP_001022866.1
  • Confirmed by transcript evidence
NP_001022867.1
  • Confirmed by transcript evidence
NP_001367850.1
  • Confirmed by transcript evidence
NP_001379955.1
  • Confirmed by transcript evidence
NP_001391146.1
  • Confirmed by transcript evidence
NP_001391147.1
  • Confirmed by transcript evidence
NP_001391148.1
  • Confirmed by transcript evidence
NP_001391150.1
  • Confirmed by transcript evidence
NP_001391152.1
  • Confirmed by transcript evidence
NP_001391153.1
  • Confirmed by transcript evidence
NP_001391155.1
  • Confirmed by transcript evidence
NP_001391156.1
  • Confirmed by transcript evidence
NP_001391159.1
  • Product from WormBase gene class mvk;
    Confirmed by transcript evidence
NP_001407509.1
  • Confirmed by transcript evidence
NP_001408259.1
  • Confirmed by transcript evidence
NP_001408260.1
  • Confirmed by transcript evidence
NP_001408261.1
  • Confirmed by transcript evidence
NP_001408262.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    6124023..6136276 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001027695.4 → NP_001022866.1  Mevalonate kinase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022866.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9N4Z7
    Conserved Domains (4) summary
    PLN02677
    Location:46 → 580
    PLN02677; mevalonate kinase
    pfam00288
    Location:265 → 347
    GHMP_kinases_N; GHMP kinases N terminal domain
    pfam08544
    Location:490 → 549
    GHMP_kinases_C; GHMP kinases C terminal
    pfam15975
    Location:378 → 447
    Flot; Flotillin

  2. NM_001404151.1 → NP_001391146.1  Mevalonate kinase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A8S4QB65

  3. NM_001027696.7 → NP_001022867.1  Mevalonate kinase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022867.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q65XX9
    Conserved Domains (4) summary
    PLN02677
    Location:146 → 587
    PLN02677; mevalonate kinase
    pfam00288
    Location:272 → 354
    GHMP_kinases_N; GHMP kinases N terminal domain
    pfam08544
    Location:497 → 556
    GHMP_kinases_C; GHMP kinases C terminal
    pfam15975
    Location:385 → 454
    Flot; Flotillin

  4. NM_001404150.1 → NP_001391150.1  Mevalonate kinase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A8S4QGK9

  5. NM_001404154.1 → NP_001391152.1  Mevalonate kinase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A8S4QAY9

  6. NM_001421328.1 → NP_001408261.1  Mevalonate kinase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A8S4QD60

  7. NM_001392117.1 → NP_001379955.1  Mevalonate kinase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q65XX8
    Conserved Domains (1) summary
    cl40731
    Location:16 → 457
    PLN02677; mevalonate kinase

  8. NM_001404159.1 → NP_001391159.1  MeValonate Kinase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A8S4QCI1

  9. NM_001379745.1 → NP_001367850.1  Mevalonate kinase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q65XY0
    Conserved Domains (1) summary
    cl40731
    Location:46 → 487
    PLN02677; mevalonate kinase

  10. NM_001421326.1 → NP_001408259.1  Mevalonate kinase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A8S4QCH2

  11. NM_001404147.1 → NP_001391147.1  Mevalonate kinase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A8S4QD84

  12. NM_001421327.1 → NP_001408260.1  Mevalonate kinase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A8S4Q9F9

  13. NM_001404149.1 → NP_001391148.1  Mevalonate kinase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A8S4QBV1

  14. NM_001404152.1 → NP_001391153.1  Mevalonate kinase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A8S4QFB7

  15. NM_001404155.1 → NP_001391156.1  Mevalonate kinase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A8S4QB79

  16. NM_001421329.1 → NP_001408262.1  Mevalonate kinase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A8S4QD98

  17. NM_001404157.1 → NP_001391155.1  Mevalonate kinase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A8S4QBV5

  18. NM_001420552.1 → NP_001407509.1  GHMP kinase C-terminal domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A8S4QBX2
Nucleotide Protein
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