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ckb-2 Choline kinase B2 [ Caenorhabditis elegans ]

Gene ID: 175565, updated on 18-Sep-2024

Summary

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Official Symbol
ckb-2
Official Full Name
Choline kinase B2
Primary source
WormBase:WBGene00000512
Locus tag
CELE_B0285.9
See related
AllianceGenome:WB:WBGene00000512
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables choline kinase activity. Involved in CDP-choline pathway and IRE1-mediated unfolded protein response. Predicted to be active in cytoplasm. Is expressed in several structures, including excretory gland cell; head mesodermal cell; intestine; pharyngeal gland cell; and uterine seam cell. Human ortholog(s) of this gene implicated in intellectual disability; megaconial type congenital muscular dystrophy; muscular dystrophy; narcolepsy; and recurrent hypersomnia. Orthologous to human CHKA (choline kinase alpha) and CHKB (choline kinase beta). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See ckb-2 in Genome Data Viewer
Location:
chromosome: III
Exon count:
8
Sequence:
Chromosome: III; NC_003281.10 (4367949..4370160)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Matrix non-peptidase homolog 1 Neighboring gene ncRNA Neighboring gene tRNA-Leu Neighboring gene Choline kinase B1 Neighboring gene ncRNA Neighboring gene Putative choline kinase B3 Neighboring gene pseudo Neighboring gene Protein containing ALS2cr12 (ALS2CR12) signature

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome-wide screen identifies a novel p97/CDC-48-dependent pathway regulating ER-stress-induced gene transcription. Marza E, et al. EMBO Rep, 2015 Mar. PMID 25652260, Free PMC Article
  2. Multiple isoforms of choline kinase from Caenorhabditis elegans: cloning, expression, purification, and characterization. Gee P, et al. Biochim Biophys Acta, 2003 May 30. PMID 12758145
  3. Small GTPase signaling and the unfolded protein response. Bouchecareilh M, et al. Methods Enzymol, 2011. PMID 21329809
  4. GTPase-mediated regulation of the unfolded protein response in Caenorhabditis elegans is dependent on the AAA+ ATPase CDC-48. Caruso ME, et al. Mol Cell Biol, 2008 Jul. PMID 18458060, Free PMC Article
  5. A survival pathway for Caenorhabditis elegans with a blocked unfolded protein response. Urano F, et al. J Cell Biol, 2002 Aug 19. PMID 12186849, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables choline kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables choline kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables choline kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables ethanolamine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in CDP-choline pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in CDP-choline pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in IRE1-mediated unfolded protein response HEP PubMed 
involved_in IRE1-mediated unfolded protein response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in endoplasmic reticulum unfolded protein response HEP PubMed 
involved_in phosphatidylcholine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylethanolamine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Choline kinase B2
NP_497880.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    4367949..4370160
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_065479.9 → NP_497880.2  Choline kinase B2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_497880.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P46559, Q8IS23
    Conserved Domains (2) summary
    PLN02236
    Location:30 → 358
    PLN02236; choline kinase
    cl21453
    Location:42 → 357
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P46559.2

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