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sel-8 Protein lag-3 [ Caenorhabditis elegans ]

Gene ID: 175464, updated on 2-Nov-2024

Summary

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Official Symbol
sel-8
Official Full Name
Protein lag-3
Primary source
WormBase:WBGene00004765
Locus tag
CELE_C32A3.1
See related
AllianceGenome:WB:WBGene00004765
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables DNA-binding transcription factor binding activity; Notch binding activity; and transcription coactivator activity. Involved in several processes, including Notch signaling pathway; positive regulation of stem cell proliferation; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; P5.p hermaphrodite; P6.p hermaphrodite; and neurons. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See sel-8 in Genome Data Viewer
Location:
chromosome: III
Exon count:
6
Sequence:
Chromosome: III; NC_003281.10 (3612951..3627142, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Tyrosine-protein phosphatase 1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Small ribosomal subunit protein mS31 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Use of protein-interaction maps to formulate biological questions. Boulton SJ, et al. Curr Opin Chem Biol, 2001 Feb. PMID 11166649
  2. Crystal structure of the CSL-Notch-Mastermind ternary complex bound to DNA. Wilson JJ, et al. Cell, 2006 Mar 10. PMID 16530045
  3. SEL-8, a nuclear protein required for LIN-12 and GLP-1 signaling in Caenorhabditis elegans. Doyle TG, et al. Proc Natl Acad Sci U S A, 2000 Jul 5. PMID 10884418, Free PMC Article
  4. Two classes of active transcription sites and their roles in developmental regulation. Robinson-Thiewes S, et al. Proc Natl Acad Sci U S A, 2020 Oct 27. PMID 33033228, Free PMC Article
  5. Mastermind is a putative activator for Notch. Petcherski AG, et al. Curr Biol, 2000 Jun 29. PMID 10898989

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Two classes of active transcription sites and their roles in developmental regulation.
    Title: Two classes of active transcription sites and their roles in developmental regulation.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables Notch binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in Notch signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of stem cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of mesodermal cell fate specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Protein lag-3
NP_001021195.1
  • Confirmed by transcript evidence
NP_001370114.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    3612951..3627142 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001384056.2 → NP_001370114.1  Protein lag-3 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q09260, Q9NGS2
    Conserved Domains (1) summary
    pfam11498
    Location:23 → 490
    Activator_LAG-3; Transcriptional activator LAG-3

  2. NM_001026024.4 → NP_001021195.1  Protein lag-3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021195.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q09260
    Conserved Domains (1) summary
    pfam11498
    Location:1 → 468
    Activator_LAG-3; Transcriptional activator LAG-3
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q09260.2

Gene LinkOut

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