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nhr-80 Nuclear hormone receptor family member nhr-80 [ Caenorhabditis elegans ]

Gene ID: 175167, updated on 2-Nov-2024

Summary

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Official Symbol
nhr-80
Official Full Name
Nuclear hormone receptor family member nhr-80
Primary source
WormBase:WBGene00003670
Locus tag
CELE_H10E21.3
See related
AllianceGenome:WB:WBGene00003670
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable DNA-binding transcription factor activity; sequence-specific DNA binding activity; and zinc ion binding activity. Involved in several processes, including determination of adult lifespan; positive regulation of fatty acid metabolic process; and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in head; intestine; muscle cell; somatic nervous system; and tail neurons. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See nhr-80 in Genome Data Viewer
Location:
chromosome: III
Exon count:
7
Sequence:
Chromosome: III; NC_003281.10 (11985..14869, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene F-box domain-containing protein Neighboring gene F-box domain-containing protein Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene Transposase Neighboring gene EF-hand domain-containing protein Neighboring gene RING-type domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Autophagy-mediated longevity is modulated by lipoprotein biogenesis. Seah NE, et al. Autophagy, 2016. PMID 26671266, Free PMC Article
  2. Graphene oxide nano-bio interaction induces inhibition of spermatogenesis and disturbance of fatty acid metabolism in the nematode Caenorhabditis elegans. Kim Y, et al. Toxicology, 2018 Dec 1. PMID 30218681
  3. Structural characterization of life-extending Caenorhabditis elegans Lipid Binding Protein 8. Tillman MC, et al. Sci Rep, 2019 Jul 10. PMID 31292465, Free PMC Article
  4. Loss of NDG-4 extends lifespan and stress resistance in Caenorhabditis elegans. Brejning J, et al. Aging Cell, 2014 Feb. PMID 24286221, Free PMC Article
  5. Fatty acid desaturation links germ cell loss to longevity through NHR-80/HNF4 in C. elegans. Goudeau J, et al. PLoS Biol, 2011 Mar. PMID 21423649, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data indicate that the NHR-80 pathway participates in the mechanism of longevity extension through depletion of the germ line.
    Title: Fatty acid desaturation links germ cell loss to longevity through NHR-80/HNF4 in C. elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in determination of adult lifespan IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in lipid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of fatty acid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in post-embryonic development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Nuclear hormone receptor family member nhr-80
NP_497126.1
  • Confirmed by transcript evidence
NP_871630.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    11985..14869 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_064725.7 → NP_497126.1  Nuclear hormone receptor family member nhr-80 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_497126.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O76668
    Conserved Domains (2) summary
    smart00399
    Location:12 → 80
    ZnF_C4; c4 zinc finger in nuclear hormone receptors
    smart00430
    Location:243 → 418
    HOLI; Ligand binding domain of hormone receptors

  2. NM_181901.2 → NP_871630.1  Nuclear hormone receptor family member nhr-80 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_871630.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O76668, Q8ITW8, Q9BJK7
    Conserved Domains (2) summary
    smart00399
    Location:30 → 98
    ZnF_C4; c4 zinc finger in nuclear hormone receptors
    smart00430
    Location:261 → 436
    HOLI; Ligand binding domain of hormone receptors
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8ITW8.1

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