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ctl-2 Peroxisomal catalase 1 [ Caenorhabditis elegans ]

Gene ID: 175085, updated on 2-Nov-2024

Summary

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Official Symbol
ctl-2
Official Full Name
Peroxisomal catalase 1
Primary source
WormBase:WBGene00000831
Locus tag
CELE_Y54G11A.5
See related
AllianceGenome:WB:WBGene00000831
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables catalase activity. Involved in determination of adult lifespan and peroxisome organization. Located in peroxisome. Human ortholog(s) of this gene implicated in several diseases, including acatalasia; eye disease (multiple); lung disease (multiple); osteonecrosis; and pseudoxanthoma elasticum. Orthologous to human CAT (catalase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ctl-2 in Genome Data Viewer
Location:
chromosome: II
Exon count:
4
Sequence:
Chromosome: II; NC_003280.10 (14299556..14302027, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Tetratricopeptide repeat protein 38 Neighboring gene Tetratricopeptide repeat protein 38 Neighboring gene Catalase-2 Neighboring gene Catalase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Thermal stress resistance and aging effects of Panax notoginseng polysaccharides on Caenorhabditis elegans. Feng S, et al. Int J Biol Macromol, 2015 Nov. PMID 26234580
  2. Impacts of methamphetamine and ketamine on C.elegans's physiological functions at environmentally relevant concentrations and eco-risk assessment in surface waters. Wang Z, et al. J Hazard Mater, 2019 Feb 5. PMID 30312923
  3. Optimization of the polysaccharide hydrolysate from Auricularia auricula with antioxidant activity by response surface methodology. Xu Y, et al. Int J Biol Macromol, 2018 Jul 1. PMID 29444471
  4. Assessing the role of polyethylene microplastics as a vector for organic pollutants in soil: Ecotoxicological and molecular approaches. Fajardo C, et al. Chemosphere, 2022 Feb. PMID 34610374
  5. Neuroprotective Effects of Extracts from Tiger Milk Mushroom Lignosus rhinocerus Against Glutamate-Induced Toxicity in HT22 Hippocampal Neuronal Cells and Neurodegenerative Diseases in Caenorhabditis elegans. Kittimongkolsuk P, et al. Biology (Basel), 2021 Jan 5. PMID 33466350, Free PMC Article

See all (109) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. peroxisomal catalase has an important role in both the development and aging of C. elegans
    Title: Lack of peroxisomal catalase causes a progeric phenotype in Caenorhabditis elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables catalase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables catalase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables catalase activity IEA
Inferred from Electronic Annotation
more info
  
enables catalase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables heme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables peroxidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables peroxidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
  
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in hydrogen peroxide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in hydrogen peroxide catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in peroxisome organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to hydrogen peroxide IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to oxidative stress IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Peroxisomal catalase 1
NP_001022473.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    14299556..14302027 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001027302.8 → NP_001022473.1  Peroxisomal catalase 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022473.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O18192, Q27487, Q9XVZ5
    Conserved Domains (1) summary
    cd08156
    Location:64 → 492
    catalase_clade_3; Clade 3 of the heme-binding enzyme catalase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q27487.3

Gene LinkOut

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