aakg-5 CBS domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: aakg-5
Official Full Name: CBS domain-containing protein
Primary source: WormBase:WBGene00011276
Locus tag: CELE_R53.7
See related: AllianceGenome:WB:WBGene00011276
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable AMP binding activity; protein kinase binding activity; and protein kinase regulator activity. Predicted to be involved in cellular response to glucose starvation; regulation of carbohydrate metabolic process; and regulation of carbon utilization. Predicted to be part of nucleotide-activated protein kinase complex. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including epithelial cell; excretory cell; hermaphrodite gonad; neurons; and rectal epithelium. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See aakg-5 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 5

Sequence:: Chromosome: II; NC_003280.10 (9971050..9974704, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

R53.7 (e-PCR)
- UniSTS:310580

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables AMP binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase regulator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cellular response to glucose starvation	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gluconeogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of carbon utilization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of glycolytic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of nucleotide-activated protein kinase complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: CBS domain-containing protein

NP_496155.1

Confirmed by transcript evidence

NP_871971.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

9971050..9974704 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_182171.4 → NP_871971.1 CBS domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_871971.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8I112

Conserved Domains (4) summary

COG0517
Location:257 → 374

CBS; CBS domain [Signal transduction mechanisms]

cd02205
Location:330 → 448

CBS_pair; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...

cd04618
Location:184 → 300

CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...

cd04621
Location:256 → 377

CBS_pair_8; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
NM_063754.6 → NP_496155.1 CBS domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_496155.1

Status: REVIEWED

UniProtKB/TrEMBL

Q22022

Conserved Domains (4) summary

COG0517
Location:229 → 346

CBS; CBS domain [Signal transduction mechanisms]

cd02205
Location:302 → 420

CBS_pair; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...

cd04618
Location:156 → 272

CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...

cd04621
Location:228 → 349

CBS_pair_8; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...