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nrf-6 Nose resistant to fluoxetine protein 6 [ Caenorhabditis elegans ]

Gene ID: 174287, updated on 18-Sep-2024

Summary

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Official Symbol
nrf-6
Official Full Name
Nose resistant to fluoxetine protein 6
Primary source
WormBase:WBGene00003813
Locus tag
CELE_C08B11.4
See related
AllianceGenome:WB:WBGene00003813
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable acyltransferase activity, transferring groups other than amino-acyl groups and lipid binding activity. Predicted to be involved in lipid transport. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in hyp3; hyp5; and intestine. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See nrf-6 in Genome Data Viewer
Location:
chromosome: II
Exon count:
13
Sequence:
Chromosome: II; NC_003280.10 (8028953..8032708, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ARID domain-containing protein;SWI/SNF nucleosome remodeling complex component Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Splicing factor 3B subunit 4 Neighboring gene Actin-like protein C08B11.6 Neighboring gene Uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. How do antidepressants work? Prospects for genetic analysis of drug mechanisms. Schafer WR. Cell, 1999 Sep 3. PMID 10490094
  2. Loss of NDG-4 extends lifespan and stress resistance in Caenorhabditis elegans. Brejning J, et al. Aging Cell, 2014 Feb. PMID 24286221, Free PMC Article
  3. Fluoxetine-resistance genes in Caenorhabditis elegans function in the intestine and may act in drug transport. Choy RK, et al. Genetics, 2006 Feb. PMID 16118202, Free PMC Article
  4. The Caenorhabditis elegans rhy-1 gene inhibits HIF-1 hypoxia-inducible factor activity in a negative feedback loop that does not include vhl-1. Shen C, et al. Genetics, 2006 Nov. PMID 16980385, Free PMC Article
  5. Fluoxetine-resistant mutants in C. elegans define a novel family of transmembrane proteins. Choy RK, et al. Mol Cell, 1999 Aug. PMID 10488330

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Nrf-6 is required in the intestine for sensitivity to fluoxetine-induced nose contraction.
    Title: Fluoxetine-resistance genes in Caenorhabditis elegans function in the intestine and may act in drug transport.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
Inferred from Electronic Annotation
more info
  
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in lipid transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Nose resistant to fluoxetine protein 6
NP_495680.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    8028953..8032708 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_063279.6 → NP_495680.1  Nose resistant to fluoxetine protein 6 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495680.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q09225, Q9U4I8
    Conserved Domains (3) summary
    smart00703
    Location:151 → 288
    NRF; N-terminal domain in C. elegans NRF-6 (Nose Resistant to Fluoxetine-4) and NDG-4 (resistant to nordihydroguaiaretic acid-4)
    COG1835
    Location:375 → 790
    OafA; Peptidoglycan/LPS O-acetylase OafA/YrhL, contains acyltransferase and SGNH-hydrolase domains [Cell wall/membrane/envelope biogenesis]
    pfam01757
    Location:375 → 777
    Acyl_transf_3; Acyltransferase family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q09225.3

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