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sma-6 Serine/threonine-protein kinase receptor sma-6 [ Caenorhabditis elegans ]

Gene ID: 174044, updated on 14-Nov-2024

Summary

Official Symbol
sma-6
Official Full Name
Serine/threonine-protein kinase receptor sma-6
Primary source
WormBase:WBGene00004860
Locus tag
CELE_C32D5.2
See related
AllianceGenome:WB:WBGene00004860
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables BMP binding activity. Involved in several processes, including defense response to other organism; nematode male tail tip morphogenesis; and positive regulation of macromolecule metabolic process. Predicted to be located in membrane and nucleus. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including ASI; hypodermis; intestine; pharynx; and tail. Human ortholog(s) of this gene implicated in several diseases, including Loeys-Dietz syndrome 1; bone development disease (multiple); carcinoma (multiple); glaucoma (multiple); and intestinal disease (multiple). Orthologous to several human genes including BMPR1B (bone morphogenetic protein receptor type 1B). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

See sma-6 in Genome Data Viewer
Location:
chromosome: II
Exon count:
12
Sequence:
Chromosome: II; NC_003280.10 (6324484..6327355)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Histone-lysine N-methyltransferase Suv4-20

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables BMP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables activin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables activin receptor activity, type I IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables transmembrane receptor protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in BMP signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in activin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell surface receptor protein serine/threonine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to growth factor stimulus IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in dauer larval development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in defense response to Gram-positive bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in defense response to fungus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in maintenance of protein location in nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nematode male tail tip morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in nematode male tail tip morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of multicellular organism growth IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transforming growth factor beta receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in reproductive process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of activin receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 

General protein information

Preferred Names
Serine/threonine-protein kinase receptor sma-6
NP_495271.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    6324484..6327355
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_062870.8NP_495271.1  Serine/threonine-protein kinase receptor sma-6 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495271.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q09488
    Conserved Domains (4) summary
    smart00467
    Location:238265
    GS; GS motif
    smart00220
    Location:266473
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14056
    Location:269605
    STKc_TGFbR_I; Catalytic domain of the Serine/Threonine Kinases, Transforming Growth Factor beta family Type I Receptors
    pfam01064
    Location:66157
    Activin_recp; Activin types I and II receptor domain