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lin-31 Protein lin-31 [ Caenorhabditis elegans ]

Gene ID: 173740, updated on 2-Nov-2024

Summary

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Official Symbol
lin-31
Official Full Name
Protein lin-31
Primary source
WormBase:WBGene00003017
Locus tag
CELE_K10G6.1
See related
AllianceGenome:WB:WBGene00003017
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables sequence-specific DNA binding activity. Involved in vulval development. Located in nucleus. Is expressed in several structures, including P10.p; P9.p; gonad; nerve ring; and vulval precursor cell. Orthologous to several human genes including FOXB2 (forkhead box B2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See lin-31 in Genome Data Viewer
Location:
chromosome: II
Exon count:
4
Sequence:
Chromosome: II; NC_003280.10 (3982549..3987029)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Delta and OSM-11-like Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Serpentine receptor class gamma Neighboring gene Ovule protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Null mutations in the lin-31 gene indicate two functions during Caenorhabditis elegans vulval development. Miller LM, et al. Genetics, 2000 Dec. PMID 11102360, Free PMC Article
  2. Mosaic analysis using a ncl-1 (+) extrachromosomal array reveals that lin-31 acts in the Pn.p cells during Caenorhabditis elegans vulval development. Miller LM, et al. Genetics, 1996 Jul. PMID 8807292, Free PMC Article
  3. A fork head/HNF-3 homolog expressed in the pharynx and intestine of the Caenorhabditis elegans embryo. Azzaria M, et al. Dev Biol, 1996 Sep 15. PMID 8812130
  4. Distinct LIN-10 domains are required for its neuronal function, its epithelial function, and its synaptic localization. Glodowski DR, et al. Mol Biol Cell, 2005 Mar. PMID 15647374, Free PMC Article
  5. Epitope-guided engineering of monobody binders for in vivo inhibition of Erk-2 signaling. Mann JK, et al. ACS Chem Biol, 2013 Mar 15. PMID 23227961, Free PMC Article

See all (87) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. lin-39 is a direct target of the Ras pathway acting via LIN-1 and LIN-31
    Title: Identification of cis-regulatory elements from the C. elegans Hox gene lin-39 required for embryonic expression and for regulation by the transcription factors LIN-1, LIN-31 and LIN-39.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in anatomical structure morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vulval development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in vulval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Protein lin-31
NP_494704.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    3982549..3987029
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_062303.5 → NP_494704.1  Protein lin-31 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_494704.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34683
    Conserved Domains (1) summary
    smart00339
    Location:13 → 101
    FH; FORKHEAD
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P34683.1

Gene LinkOut

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