nmur-2 Neuromedin U receptor homolog nmur-2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: nmur-2
Official Full Name: Neuromedin U receptor homolog nmur-2
Primary source: WormBase:WBGene00019616
Locus tag: CELE_K10B4.4
See related: AllianceGenome:WB:WBGene00019616
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables neuropeptide receptor activity. Involved in neuropeptide signaling pathway. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Orthologous to human NMUR1 (neuromedin U receptor 1) and NMUR2 (neuromedin U receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See nmur-2 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 7

Sequence:: Chromosome: II; NC_003280.10 (123270..125004, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Orphan G protein-coupled receptor in the nematode Caenorhabditis elegans (Ce-PK-R) was found.
Title: A neuromedin-pyrokinin-like neuropeptide signaling system in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

K10B4.4 (e-PCR)
- UniSTS:311529

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables neuropeptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables neuropeptide receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables neuropeptide receptor activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuropeptide signaling pathway	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Neuromedin U receptor homolog nmur-2

NP_493666.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

123270..125004 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_061265.4 → NP_493666.2 Neuromedin U receptor homolog nmur-2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_493666.2

Status: REVIEWED

UniProtKB/Swiss-Prot

O17239

Conserved Domains (1) summary

cd15134
Location:32 → 346

7tmA_capaR; neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors