T27F6.6 Putative neutral sphingomyelinase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: T27F6.6
Official Full Name: Putative neutral sphingomyelinase
Primary source: WormBase:WBGene00012105
Locus tag: CELE_T27F6.6
See related: AllianceGenome:WB:WBGene00012105
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable sphingomyelin phosphodiesterase activity. Predicted to be involved in ceramide biosynthetic process; sphingolipid catabolic process; and sphingomyelin metabolic process. Predicted to be located in membrane. Predicted to be active in caveola and endoplasmic reticulum. Is expressed in intestine and nervous system. Orthologous to human SMPD2 (sphingomyelin phosphodiesterase 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See T27F6.6 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 6

Sequence:: Chromosome: I; NC_003279.8 (12490976..12494530)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T27F6.6 (e-PCR)
- UniSTS:318554

T27F6.5 (e-PCR)
- UniSTS:315123

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables sphingomyelin phosphodiesterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables sphingomyelin phosphodiesterase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ceramide biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in sphingolipid catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in sphingolipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in sphingomyelin metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in caveola	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cell periphery	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Putative neutral sphingomyelinase

NP_493169.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

12490976..12494530

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_060768.7 → NP_493169.2 Putative neutral sphingomyelinase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_493169.2

Status: REVIEWED

UniProtKB/Swiss-Prot

O45870

Conserved Domains (2) summary

cl00490
Location:41 → 321

EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

cl00649
Location:365 → 421

DsbB; Disulfide bond formation protein DsbB