erm-1 Moesin/ezrin/radixin homolog 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: erm-1
Official Full Name: Moesin/ezrin/radixin homolog 1
Primary source: WormBase:WBGene00001333
Locus tag: CELE_C01G8.5
See related: AllianceGenome:WB:WBGene00001333
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables cytoskeletal anchor activity and structural molecule activity. Involved in several processes, including actin filament organization; nematode larval development; and protein localization to basolateral plasma membrane. Located in several cellular components, including actin filament; apical cortex; and apical plasma membrane. Is expressed in several structures, including anal sphincter muscle; excretory cell; intestine; nervous system; and reproductive system. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 24 and immunodeficiency 50. Orthologous to several human genes including EZR (ezrin) and MSN (moesin). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See erm-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 12

Sequence:: Chromosome: I; NC_003279.8 (5284026..5291604, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

C-terminal phosphorylation modulates ERM-1 localization and dynamics to control cortical actin organization and support lumen formation during Caenorhabditis elegans development.
Title: C-terminal phosphorylation modulates ERM-1 localization and dynamics to control cortical actin organization and support lumen formation during Caenorhabditiselegans development.
We evidence that wild-type ezrin (ezrinWT) and its phosphomimetic mutant T567D (ezrinTD) do not deform membranes but self-assemble anti-parallelly, zipping adjacent membranes. EzrinTD's specific conformation reduces intermolecular interactions, allows binding to actin filaments, which reduces membrane tethering, and promotes ezrin binding to positively-curved membranes.
Title: Ezrin enrichment on curved membranes requires a specific conformation or interaction with a curvature-sensitive partner.
fortifying the link between the apical membrane and actin cortex by overexpression of the ezrin/radixin/moesin ortholog ERM-1, significantly rescued cyst formation and ruptures in the pigv-1(qm34) mutant.
Title: Glycosyl phosphatidylinositol anchor biosynthesis is essential for maintaining epithelial integrity during Caenorhabditis elegans embryogenesis.
ERM-1 prevents the immediate activation of the entire pool of LET-23 EGFR and permits the generation of a long-lasting inductive signal
Title: An in vivo EGF receptor localization screen in C. elegans Identifies the Ezrin homolog ERM-1 as a temporal regulator of signaling.
Propose that the ERM-1/AQP-8 interaction propels lumen extension by translumenal flux, suggesting a direct morphogenetic effect of water-channel-regulated fluid pressure.
Title: Intracellular lumen extension requires ERM-1-dependent apical membrane expansion and AQP-8-mediated flux.
The novel intestinal filament organizer IFO-1 contributes to epithelial integrity in concert with ERM-1 and DLG-1.
Title: The novel intestinal filament organizer IFO-1 contributes to epithelial integrity in concert with ERM-1 and DLG-1.
Genetic analysis indicates that mig-15 and erm-1 act in the same genetic pathway to regulate growth cone migration, and this pathway functions in parallel to the UNC-116/WVE-1 pathway.
Title: MIG-15 and ERM-1 promote growth cone directional migration in parallel to UNC-116 and WVE-1.
ERM-1 localizes to the luminal membranes of tubular organ epithelia which lack stabilization by cuticle. RNAi, a germline deletion, and overexpression of erm-1 cause cystic luminal phenotypes in these epithelia.
Title: Lumen morphogenesis in C. elegans requires the membrane-cytoskeleton linker erm-1.
ERM-1 is the first protein of the apical membrane domain affecting junction remodelling in C. elegans
Title: The C. elegans ezrin-radixin-moesin protein ERM-1 is necessary for apical junction remodelling and tubulogenesis in the intestine.
The ERM proteins ezrin and moesin were found to strongly co-localise with both ICAM-1 and F-actin in brain microvascular endothelial cells suggesting a potential role in mediating ICAM-1 signalling.
Title: Ezrin and moesin co-localise with ICAM-1 in brain endothelial cells but are not directly associated.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C01G8.5 (e-PCR)
- UniSTS:318882

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables actin binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables cell adhesion molecule binding	IBA Inferred from Biological aspect of Ancestor more info
enables cytoskeletal anchor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables cytoskeletal protein binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural molecule activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in actin filament organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in morphogenesis of an epithelium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nematode larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of early endosome to late endosome transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of protein localization to early endosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to basolateral plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell shape	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of organelle assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in tube formation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in actin filament	IDA Inferred from Direct Assay more info	PubMed
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
located_in adherens junction	IEA Inferred from Electronic Annotation more info
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in apical cortex	IDA Inferred from Direct Assay more info	PubMed
is_active_in apical part of cell	IBA Inferred from Biological aspect of Ancestor more info
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in filopodium	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane-enclosed lumen	IDA Inferred from Direct Assay more info	PubMed
is_active_in microvillus	IBA Inferred from Biological aspect of Ancestor more info
located_in microvillus	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Moesin/ezrin/radixin homolog 1

NP_491559.1

Confirmed by transcript evidence

NP_491560.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

5284026..5291604 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_059158.7 → NP_491559.1 Moesin/ezrin/radixin homolog 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_491559.1

Status: REVIEWED

UniProtKB/TrEMBL

G5EES2, G5EGU8

Conserved Domains (3) summary

smart00295
Location:8 → 207

B41; Band 4.1 homologues

cd13194
Location:201 → 297

FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family

pfam00769
Location:332 → 563

ERM; Ezrin/radixin/moesin family
NM_059159.4 → NP_491560.1 Moesin/ezrin/radixin homolog 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_491560.1

Status: REVIEWED

UniProtKB/TrEMBL

G5EBK3, G5EGU8

Conserved Domains (4) summary

smart00295
Location:9 → 208

B41; Band 4.1 homologues

cd13194
Location:202 → 298

FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family

pfam00769
Location:333 → 564

ERM; Ezrin/radixin/moesin family

pfam02029
Location:302 → 362

Caldesmon