lpd-5 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [Caenorhabditis elegans] - Gene

Summary

Official Symbol: lpd-5
Official Full Name: NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial
Primary source: WormBase:WBGene00003061
Locus tag: CELE_ZK973.10
See related: AllianceGenome:WB:WBGene00003061
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable oxidoreductase activity, acting on NAD(P)H. Involved in lipid storage. Predicted to be located in mitochondrial inner membrane and respirasome. Predicted to be part of mitochondrial respiratory chain complex I. Human ortholog(s) of this gene implicated in Leigh disease and nuclear type mitochondrial complex I deficiency 1. Orthologous to human NDUFS4 (NADH:ubiquinone oxidoreductase subunit S4). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Process	Evidence Code	Pubs
involved_in electron transport chain	IEA Inferred from Electronic Annotation more info
involved_in lipid storage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial electron transport, NADH to ubiquinone	IC Inferred by Curator more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
part_of respiratory chain complex	IEA Inferred from Electronic Annotation more info
part_of respiratory chain complex I	IBA Inferred from Biological aspect of Ancestor more info
part_of respiratory chain complex I	ISS Inferred from Sequence or Structural Similarity more info

Preferred Names: NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial

NP_001370829.1

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