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guk-1 guanylate kinase [ Caenorhabditis elegans ]

Gene ID: 171963, updated on 2-Nov-2024

Summary

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Official Symbol
guk-1
Official Full Name
guanylate kinase
Primary source
WormBase:WBGene00020190
Locus tag
CELE_T03F1.8
See related
AllianceGenome:WB:WBGene00020190
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable guanylate kinase activity. Predicted to be involved in GDP metabolic process and GMP metabolic process. Predicted to be active in cytosol. Is expressed in anchor cell. Orthologous to human GUK1 (guanylate kinase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See guk-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
6
Sequence:
Chromosome: I; NC_003279.8 (3859369..3862733, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene F-box domain-containing protein Neighboring gene EF-hand domain-containing protein Neighboring gene Dimethyladenosine transferase 1, mitochondrial Neighboring gene HoloCentric chromosome binding Protein Neighboring gene putative phosphoglycerate kinase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly. Schaan Profes M, et al. PLoS Biol, 2024 Jan. PMID 38252619, Free PMC Article
  2. A modified TurboID approach identifies tissue-specific centriolar components in C. elegans. Holzer E, et al. PLoS Genet, 2022 Apr. PMID 35442950, Free PMC Article
  3. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
  4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables guanylate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanylate kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in GDP metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in GMP metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in purine nucleotide metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
guanylate kinase
NP_001122511.1
  • Confirmed by transcript evidence
NP_491243.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    3859369..3862733 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058842.7 → NP_491243.1  guanylate kinase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491243.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    P91425
    Conserved Domains (1) summary
    TIGR03263
    Location:25 → 208
    guanyl_kin; guanylate kinase

  2. NM_001129039.6 → NP_001122511.1  guanylate kinase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001122511.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A5HU98
    Conserved Domains (1) summary
    TIGR03263
    Location:14 → 197
    guanyl_kin; guanylate kinase
Nucleotide Protein
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