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lpd-3 Bridge-like lipid transfer protein family member 1 C-terminal domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 171926, updated on 2-Nov-2024

Summary

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Official Symbol
lpd-3
Official Full Name
Bridge-like lipid transfer protein family member 1 C-terminal domain-containing protein
Primary source
WormBase:WBGene00003060
Locus tag
CELE_Y47G6A.23
See related
AllianceGenome:WB:WBGene00003060
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be located in membrane and presynapse. Is expressed in intestine. Human ortholog(s) of this gene implicated in Alkuraya-Kucinskas syndrome. Orthologous to human BLTP1 (bridge-like lipid transfer protein family member 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See lpd-3 in Genome Data Viewer
Location:
chromosome: I
Exon count:
31
Sequence:
Chromosome: I; NC_003279.8 (3564963..3600735, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene DeHydrogenases, Short chain Neighboring gene pseudo Neighboring gene DeHydrogenases, Short chain Neighboring gene C6 domain-containing protein Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene RING-type domain-containing protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Bridge-Like Lipid Transfer Proteins (BLTPs) in C. elegans: From Genetics to Structures and Functions. Pandey T, et al. Contact (Thousand Oaks), 2023 Jan-Dec. PMID 37455813, Free PMC Article
  2. Vps13-like proteins provide phosphatidylethanolamine for GPI anchor synthesis in the ER. Toulmay A, et al. J Cell Biol, 2022 Mar 7. PMID 35015055, Free PMC Article
  3. C elegans: a model for exploring the genetics of fat storage. McKay RM, et al. Dev Cell, 2003 Jan. PMID 12530969, Free PMC Article
  4. LPD-3 as a megaprotein brake for aging and insulin-mTOR signaling in C. elegans. Pandey T, et al. Cell Rep, 2024 Mar 26. PMID 38446666, Free PMC Article
  5. A conserved megaprotein-based molecular bridge critical for lipid trafficking and cold resilience. Wang C, et al. Nat Commun, 2022 Nov 10. PMID 36357390, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LPD-3 as a megaprotein brake for aging and insulin-mTOR signaling in C. elegans.
    Title: LPD-3 as a megaprotein brake for aging and insulin-mTOR signaling in C. elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in synaptic vesicle endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in presynapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Bridge-like lipid transfer protein family member 1 C-terminal domain-containing protein
NP_001300464.1
  • Confirmed by transcript evidence
NP_001300465.1
  • Confirmed by transcript evidence
NP_001300466.1
  • Confirmed by transcript evidence
NP_001300467.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    3564963..3600735 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001313535.2 → NP_001300464.1  Bridge-like lipid transfer protein family member 1 C-terminal domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3ATS5
    Conserved Domains (1) summary
    pfam10479
    Location:3363 → 3860
    FSA_C; Fragile site-associated protein C-terminus

  2. NM_001313538.2 → NP_001300467.1  Bridge-like lipid transfer protein family member 1 C-terminal domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AWP8
    Conserved Domains (1) summary
    pfam10479
    Location:3367 → 3864
    FSA_C; Fragile site-associated protein C-terminus

  3. NM_001313537.3 → NP_001300466.1  Bridge-like lipid transfer protein family member 1 C-terminal domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AUC6
    Conserved Domains (1) summary
    pfam10479
    Location:3365 → 3862
    FSA_C; Fragile site-associated protein C-terminus

  4. NM_001313536.3 → NP_001300465.1  Bridge-like lipid transfer protein family member 1 C-terminal domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AQT9
    Conserved Domains (1) summary
    pfam10479
    Location:3365 → 3862
    FSA_C; Fragile site-associated protein C-terminus
Nucleotide Protein
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