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pign-1 GPI ethanolamine phosphate transferase 1 [ Caenorhabditis elegans ]

Gene ID: 171881, updated on 18-Sep-2024

Summary

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Official Symbol
pign-1
Official Full Name
GPI ethanolamine phosphate transferase 1
Primary source
WormBase:WBGene00021840
Locus tag
CELE_Y54E10BR.1
See related
AllianceGenome:WB:WBGene00021840
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable mannose-ethanolamine phosphotransferase activity. Predicted to be involved in GPI anchor biosynthetic process. Is integral component of endoplasmic reticulum membrane. Is expressed in body wall musculature; hypodermis; intestine; and pharynx. Human ortholog(s) of this gene implicated in multiple congenital anomalies-hypotonia-seizures syndrome 1. Orthologous to human PIGN (phosphatidylinositol glycan anchor biosynthesis class N). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See pign-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
13
Sequence:
Chromosome: I; NC_003279.8 (3057694..3069410)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ADP-ribosylation factor-related protein 1 Neighboring gene DNA-directed RNA polymerase II subunit RPB7 Neighboring gene Transporter Neighboring gene C2H2-type domain-containing protein Neighboring gene Ensconsin Neighboring gene Actin-related protein 2/3 complex subunit 5 Neighboring gene Serine/threonine-protein kinase RIO1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. New allele of C. elegans gene pign-1, named as xyz11. Narimatsu T, et al. MicroPubl Biol, 2019 Jan 18. PMID 32550470, Free PMC Article
  2. PIGN prevents protein aggregation in the endoplasmic reticulum independently of its function in the GPI synthesis. Ihara S, et al. J Cell Sci, 2017 Feb 1. PMID 27980068
  3. The Arp2/3 complex, UNC-115/abLIM, and UNC-34/Enabled regulate axon guidance and growth cone filopodia formation in Caenorhabditis elegans. Norris AD, et al. Neural Dev, 2009 Oct 2. PMID 19799769, Free PMC Article
  4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PIGN-1/PIGN is required for quality control in Caenorhabditis elegans and in mammalian cells.
    Title: PIGN prevents protein aggregation in the endoplasmic reticulum independently of its function in the GPI synthesis.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables mannose-ethanolamine phosphotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mannose-ethanolamine phosphotransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in GPI anchor biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in GPI anchor biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
GPI ethanolamine phosphate transferase 1
NP_001249296.1
  • Partially confirmed by transcript evidence
NP_001249297.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    3057694..3069410
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001262368.4 → NP_001249297.1  GPI ethanolamine phosphate transferase 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001249297.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9N3C5
    Conserved Domains (2) summary
    cd16020
    Location:42 → 320
    GPI_EPT_1; GPI ethanolamine phosphate transferase 1; PIG-N
    pfam04987
    Location:404 → 844
    PigN; Phosphatidylinositolglycan class N (PIG-N)

  2. NM_001262367.2 → NP_001249296.1  GPI ethanolamine phosphate transferase 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001249296.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G4SNP0
    Conserved Domains (2) summary
    cd16020
    Location:42 → 320
    GPI_EPT_1; GPI ethanolamine phosphate transferase 1; PIG-N
    pfam04987
    Location:404 → 850
    PigN; Phosphatidylinositolglycan class N (PIG-N)
Nucleotide Protein
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