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dot-1.1 Histone-lysine N-methyltransferase, H3 lysine-79 specific [ Caenorhabditis elegans ]

Gene ID: 171797, updated on 18-Sep-2024

Summary

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Official Symbol
dot-1.1
Official Full Name
Histone-lysine N-methyltransferase, H3 lysine-79 specific
Primary source
WormBase:WBGene00021474
Locus tag
CELE_Y39G10AR.18
See related
AllianceGenome:WB:WBGene00021474
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable histone methyltransferase activity (H3-K79 specific). Predicted to be involved in several processes, including DNA damage checkpoint signaling; regulation of transcription regulatory region DNA binding activity; and subtelomeric heterochromatin assembly. Predicted to be located in chromosome, telomeric region. Predicted to be active in nucleus. Is expressed widely. Human ortholog(s) of this gene implicated in mixed phenotype acute leukemia. Orthologous to human DOT1L (DOT1 like histone lysine methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See dot-1.1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
16
Sequence:
Chromosome: I; NC_003279.8 (2382953..2401492, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene non-specific serine/threonine protein kinase Neighboring gene ncRNA Neighboring gene Synaptic defective enhancer 1 Neighboring gene Protein zwilch homolog Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Caenorhabditis elegans Deficient in DOT-1.1 Exhibit Increases in H3K9me2 at Enhancer and Certain RNAi-Regulated Regions. Esse R, et al. Cells, 2020 Aug 6. PMID 32781660, Free PMC Article
  2. DOT-1.1-dependent H3K79 methylation promotes normal meiotic progression and meiotic checkpoint function in C. elegans. Lascarez-Lagunas LI, et al. PLoS Genet, 2020 Oct. PMID 33104701, Free PMC Article
  3. DOT1L complex suppresses transcription from enhancer elements and ectopic RNAi in Caenorhabditis elegans. Esse R, et al. RNA, 2019 Oct. PMID 31300558, Free PMC Article
  4. Restriction of Cellular Plasticity of Differentiated Cells Mediated by Chromatin Modifiers, Transcription Factors and Protein Kinases. Rahe DP, et al. G3 (Bethesda), 2019 Jul 9. PMID 31088904, Free PMC Article
  5. An interplay of miRNA abundance and target site architecture determines miRNA activity and specificity. Brancati G, et al. Nucleic Acids Res, 2018 Apr 20. PMID 29897601, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Caenorhabditis elegans Deficient in DOT-1.1 Exhibit Increases in H3K9me2 at Enhancer and Certain RNAi-Regulated Regions.
    Title: Caenorhabditis elegans Deficient in DOT-1.1 Exhibit Increases in H3K9me2 at Enhancer and Certain RNAi-Regulated Regions.
  2. DOT-1.1-dependent H3K79 methylation promotes normal meiotic progression and meiotic checkpoint function in C. elegans.
    Title: DOT-1.1-dependent H3K79 methylation promotes normal meiotic progression and meiotic checkpoint function in C. elegans.
  3. Recruitment of ZFP-1/DOT-1.1 and deposition of H3K79 methylation at highly expressed genes initiates a negative feedback mechanism for the modulation of their expression.
    Title: The ZFP-1(AF10)/DOT-1 complex opposes H2B ubiquitination to reduce Pol II transcription.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables histone H3K79 methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H3K79 methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3K79 trimethyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA damage checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in subtelomeric heterochromatin formation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Histone-lysine N-methyltransferase, H3 lysine-79 specific
NP_001368488.1
  • Confirmed by transcript evidence
NP_740808.2
  • Confirmed by transcript evidence
NP_740809.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    2382953..2401492 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_170824.4 → NP_740808.2  Histone-lysine N-methyltransferase, H3 lysine-79 specific [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_740808.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A061AD87, Q6AW05, Q6AW06
    Conserved Domains (1) summary
    pfam08123
    Location:151 → 356
    DOT1; Histone methylation protein DOT1

  2. NM_170825.4 → NP_740809.2  Histone-lysine N-methyltransferase, H3 lysine-79 specific [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_740809.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6AW05

  3. NM_001381392.1 → NP_001368488.1  Histone-lysine N-methyltransferase, H3 lysine-79 specific [Caenorhabditis elegans]

    Status: REVIEWED

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6AW06.2

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