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atg-5 Autophagy-related protein 5 [ Caenorhabditis elegans ]

Gene ID: 171735, updated on 18-Sep-2024

Summary

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Official Symbol
atg-5
Official Full Name
Autophagy-related protein 5
Primary source
WormBase:WBGene00022152
Locus tag
CELE_Y71G12B.12
See related
AllianceGenome:WB:WBGene00022152
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in autophagosome assembly and regulation of autophagy. Predicted to be located in cytoplasm and membrane. Predicted to be part of Atg12-Atg5-Atg16 complex. Predicted to be active in phagophore assembly site membrane. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 25. Orthologous to human ATG5 (autophagy related 5). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See atg-5 in Genome Data Viewer
Location:
chromosome: I
Exon count:
4
Sequence:
Chromosome: I; NC_003279.8 (1709587..1715564)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene RING-type domain-containing protein Neighboring gene Sm domain-containing protein Neighboring gene FERM domain-containing protein;I/LWEQ domain-containing protein;Talin central domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Mitochondrial-processing peptidase subunit alpha

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Unexpected cell type-dependent effects of autophagy on polyglutamine aggregation revealed by natural genetic variation in C. elegans. Alexander-Floyd J, et al. BMC Biol, 2020 Feb 24. PMID 32093691, Free PMC Article
  2. Autophagy in C. elegans. Meléndez A, et al. WormBook, 2009 Aug 24. PMID 19705512
  3. The two C. elegans ATG-16 homologs have partially redundant functions in the basal autophagy pathway. Zhang H, et al. Autophagy, 2013 Dec. PMID 24185444, Free PMC Article
  4. Structural Basis of the Differential Function of the Two C. elegans Atg8 Homologs, LGG-1 and LGG-2, in Autophagy. Wu F, et al. Mol Cell, 2015 Dec 17. PMID 26687600
  5. Autophagy is required for necrotic cell death in Caenorhabditis elegans. Samara C, et al. Cell Death Differ, 2008 Jan. PMID 17901876

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
contributes_to Atg8-family ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in aggrephagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in autophagosome assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in autophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in autophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to nitrogen starvation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in macroautophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in mitophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in piecemeal microautophagy of the nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Atg12-Atg5-Atg16 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in autophagosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in phagophore IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in phagophore assembly site membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in phagophore assembly site membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Autophagy-related protein 5
NP_001293440.1
  • Confirmed by transcript evidence
NP_490885.3
  • Confirmed by transcript evidence
NP_871858.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    1709587..1715564
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058484.9 → NP_490885.3  Autophagy-related protein 5 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_490885.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q3V5I7, Q3V5I8, W6RR39
    Conserved Domains (1) summary
    pfam04106
    Location:79 → 271
    APG5; Autophagy protein Apg5

  2. NM_001306511.5 → NP_001293440.1  Autophagy-related protein 5 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293440.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    W6RR39
    Conserved Domains (1) summary
    pfam04106
    Location:79 → 269
    APG5; Autophagy protein Apg5

  3. NM_182058.5 → NP_871858.2  Autophagy-related protein 5 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_871858.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q3V5I8
    Conserved Domains (1) summary
    pfam04106
    Location:79 → 158
    APG5; Autophagy protein Apg5
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3V5I7.2

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