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Acsbg1 acyl-CoA synthetase bubblegum family member 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 171410, updated on 17-Aug-2024

Summary

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Official Symbol
Acsbg1provided by RGD
Official Full Name
acyl-CoA synthetase bubblegum family member 1provided by RGD
Primary source
RGD:708557
See related
EnsemblRapid:ENSRNOG00000011381 AllianceGenome:RGD:708557
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Lpd; Grlacs
Summary
Predicted to enable long-chain fatty acid-CoA ligase activity and very long-chain fatty acid-CoA ligase activity. Involved in long-chain fatty acid biosynthetic process and ovarian follicle atresia. Located in cytoplasm. Human ortholog(s) of this gene implicated in adrenoleukodystrophy. Orthologous to human ACSBG1 (acyl-CoA synthetase bubblegum family member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 344.0) and Brain (RPKM 175.5) See more
Orthologs
human mouse all
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Genomic context

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See Acsbg1 in Genome Data Viewer
Location:
8q24
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (63887433..63943486, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (54991294..55047276, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (59184111..59240133, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene SH2 domain containing 7 Neighboring gene calcium and integrin binding family member 2 Neighboring gene isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha Neighboring gene DnaJ heat shock protein family (Hsp40) member A4 Neighboring gene SKI8 subunit of superkiller complex

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. DNA methylation analysis in malignant pheochromocytoma and paraganglioma. Oishi T, et al. J Clin Transl Endocrinol, 2017 Mar. PMID 29067245, Free PMC Article
  2. Tissue-cell- and species-specific expression of gonadotropin-regulated long chain acyl-CoA synthetase (GR-LACS) in gonads, adrenal and brain. Identification of novel forms in the brain. Li J, et al. J Steroid Biochem Mol Biol, 2006 Mar. PMID 16469493
  3. Lessons from the gonadotropin-regulated long chain acyl-CoA synthetase (GR-LACS) null mouse model: a role in steroidogenesis, but not result in X-ALD phenotype. Sheng Y, et al. J Steroid Biochem Mol Biol, 2009 Mar. PMID 19167491
  4. Expression of an acyl-CoA synthetase, lipidosin, in astrocytes of the murine brain and its up-regulation during remyelination following cuprizone-induced demyelination. Song SY, et al. J Neurosci Res, 2007 Dec. PMID 17722065
  5. Cloning and characterization of a hormonally regulated rat long chain acyl-CoA synthetase. Tang PZ, et al. Proc Natl Acad Sci U S A, 2001 Jun 5. PMID 11381125, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables long-chain fatty acid-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables long-chain fatty acid-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables long-chain fatty acid-CoA ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables long-chain fatty acid-CoA ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables very long-chain fatty acid-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables very long-chain fatty acid-CoA ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables very long-chain fatty acid-CoA ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in long-chain fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in long-chain fatty acid biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in long-chain fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in long-chain fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in long-chain fatty acid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in ovarian follicle atresia IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to glucocorticoid IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to glucocorticoid ISO
Inferred from Sequence Orthology
more info
  
involved_in very long-chain fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in very long-chain fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in very long-chain fatty acid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
NOT located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
NOT located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
NOT located_in peroxisome ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
long-chain-fatty-acid--CoA ligase ACSBG1
Names
gonadotropin-regulated long chain acyl CoA synthetase
lipidosin
NP_599216.1
XP_038936682.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_134389.1 → NP_599216.1  long-chain-fatty-acid--CoA ligase ACSBG1

    See identical proteins and their annotated locations for NP_599216.1

    Status: PROVISIONAL

    Source sequence(s)
    AF208125
    UniProtKB/Swiss-Prot
    Q924N5
    UniProtKB/TrEMBL
    A0A8L2Q8K6
    Related
    ENSRNOP00000016104.4, ENSRNOT00000016104.6
    Conserved Domains (1) summary
    cd05933
    Location:122 → 716
    ACSBG_like; Bubblegum-like very long-chain fatty acid CoA synthetase (VL-FACS)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    63887433..63943486 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039080754.2 → XP_038936682.1  long-chain-fatty-acid--CoA ligase ACSBG1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZUY7, A0A8L2Q8K6
    Related
    ENSRNOP00000082463.1, ENSRNOT00000098670.2
    Conserved Domains (1) summary
    cl17068
    Location:163 → 698
    AFD_class_I; Adenylate forming domain, Class I superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q924N5.1 GenPept UniProtKB/Swiss-Prot:Q924N5

Gene LinkOut

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