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Ppp4c protein phosphatase 4, catalytic subunit [ Rattus norvegicus (Norway rat) ]

Gene ID: 171366, updated on 2-Nov-2024

Summary

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Official Symbol
Ppp4cprovided by RGD
Official Full Name
protein phosphatase 4, catalytic subunitprovided by RGD
Primary source
RGD:621225
See related
EnsemblRapid:ENSRNOG00000019813 AllianceGenome:RGD:621225
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ppx
Summary
Enables lamin binding activity and phosphatase activity. Involved in cellular response to interleukin-1; dephosphorylation; and negative regulation of protein phosphorylation. Located in nucleus. Orthologous to human PPP4C (protein phosphatase 4 catalytic subunit). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 242.2), Spleen (RPKM 209.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ppp4c in Genome Data Viewer
Location:
1q36
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (190823447..190830247, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (181392899..181399703, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (198219012..198225775, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene glycerophosphodiester phosphodiesterase domain containing 3 Neighboring gene yippee-like 3 Neighboring gene T-box transcription factor 6 Neighboring gene uncharacterized LOC103691235 Neighboring gene aldolase, fructose-bisphosphate A Neighboring gene U6 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Expression of protein phosphatase 4 in different tissues under hypoxia. Ma Y, et al. Indian J Pathol Microbiol, 2023 Jul-Sep. PMID 37530343
  2. Integrative analysis of promising molecular biomarkers and pathways for coronary artery disease using WGCNA and MetaDE methods. Yan S. Mol Med Rep, 2018 Sep. PMID 30015926, Free PMC Article
  3. Localization of a nuclear serine/threonine protein phosphatase in insulin-secreting INS-1 cells: potential regulation by IL-1beta. Veluthakal R, et al. Apoptosis, 2006 Aug. PMID 16830232
  4. Expression and regulation of type 2A protein phosphatases and alpha4 signalling in cardiac health and hypertrophy. Eleftheriadou O, et al. Basic Res Cardiol, 2017 Jul. PMID 28526910, Free PMC Article
  5. A novel 50 kDa protein forms complexes with protein phosphatase 4 and is located at centrosomal microtubule organizing centres. Hastie CJ, et al. Biochem J, 2000 May 1. PMID 10769191, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Expression of protein phosphatase 4 in different tissues under hypoxia.
    Title: Expression of protein phosphatase 4 in different tissues under hypoxia.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC94490

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables lamin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to interleukin-1 IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in dephosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of double-strand break repair ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of double-strand break repair via homologous recombination IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of double-strand break repair via homologous recombination ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromatin IEA
Inferred from Electronic Annotation
more info
  
located_in chromatin ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of protein phosphatase 4 complex IEA
Inferred from Electronic Annotation
more info
  
part_of protein phosphatase 4 complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
serine/threonine-protein phosphatase 4 catalytic subunit
Names
PP4C
pp4
protein phosphatase 4 (formerly X), catalytic subunit
NP_599186.1
XP_006230268.1
XP_017444223.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_134359.1 → NP_599186.1  serine/threonine-protein phosphatase 4 catalytic subunit

    See identical proteins and their annotated locations for NP_599186.1

    Status: PROVISIONAL

    Source sequence(s)
    BC091574
    UniProtKB/Swiss-Prot
    Q5BJ92
    Conserved Domains (2) summary
    PTZ00239
    Location:6 → 307
    PTZ00239; serine/threonine protein phosphatase 2A; Provisional
    cd07415
    Location:6 → 290
    MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    190823447..190830247 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006230206.3 → XP_006230268.1  serine/threonine-protein phosphatase 4 catalytic subunit isoform X1

    See identical proteins and their annotated locations for XP_006230268.1

    UniProtKB/TrEMBL
    A6I9D8, G3V8M5
    Related
    ENSRNOP00000026909.4, ENSRNOT00000026909.9
    Conserved Domains (1) summary
    cd07415
    Location:6 → 290
    MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain

  2. XM_017588734.3 → XP_017444223.1  serine/threonine-protein phosphatase 4 catalytic subunit isoform X2

    Conserved Domains (1) summary
    cd07415
    Location:1 → 211
    MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5BJ92.1 GenPept UniProtKB/Swiss-Prot:Q5BJ92

Gene LinkOut

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