Zdhhc7 zinc finger DHHC-type palmitoyltransferase 7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Zdhhc7provided by RGD
Official Full Name: zinc finger DHHC-type palmitoyltransferase 7provided by RGD
Primary source: RGD:620205
See related: EnsemblRapid:ENSRNOG00000017342 AllianceGenome:RGD:620205
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: DHHC7; Serz1; Serz-1
Summary: Predicted to enable protein-cysteine S-palmitoyltransferase activity. Predicted to be involved in several processes, including glucose import in response to insulin stimulus; peptidyl-L-cysteine S-palmitoylation; and regulation of signal transduction. Predicted to be located in nucleoplasm. Predicted to be active in Golgi apparatus and endoplasmic reticulum. Orthologous to human ZDHHC7 (zinc finger DHHC-type palmitoyltransferase 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 139.7), Spleen (RPKM 127.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19q12

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (65048140..65065286, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (48139309..48156673, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (52733161..52750307, complement)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH129286 (e-PCR)
- UniSTS:212593

AI029017 (e-PCR)
- UniSTS:245982

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables palmitoyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein-cysteine S-myristoyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein-cysteine S-palmitoyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-cysteine S-palmitoyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein-cysteine S-palmitoyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein-cysteine S-palmitoyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein-cysteine S-stearoyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in androgen receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in androgen receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in glucose import in response to insulin stimulus	ISO Inferred from Sequence Orthology more info
involved_in glucose import in response to insulin stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of catabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in peptidyl-L-cysteine S-palmitoylation	IEA Inferred from Electronic Annotation more info
involved_in peptidyl-L-cysteine S-palmitoylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-L-cysteine S-palmitoylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in polarized epithelial cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in polarized epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in polarized epithelial cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in progesterone receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in progesterone receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein palmitoylation	ISO Inferred from Sequence Orthology more info
involved_in protein palmitoylation	ISO Inferred from Sequence Orthology more info
involved_in protein palmitoylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein targeting to membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of Fas signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in regulation of Fas signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of Fas signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in regulation of G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of protein localization to cell-cell junction	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein localization to cell-cell junction	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein localization to cell-cell junction	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of protein localization to plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein localization to plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in steroid hormone receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: palmitoyltransferase ZDHHC7

Names: DHHC-7; acyltransferase ZDHHC7; membrane-associated DHHC7 zinc finger protein; putative zinc finger protein SERZ-1; sertoli cell gene with a zinc finger domain protein; zinc finger DHHC domain-containing protein 7; zinc finger, DHHC domain containing 7; zinc finger, DHHC-type containing 7

NP_596885.1

EC 2.3.1.225

XP_038953366.1

EC 2.3.1.225

XP_063133814.1

EC 2.3.1.225

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133394.2 → NP_596885.1 palmitoyltransferase ZDHHC7

See identical proteins and their annotated locations for NP_596885.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000019

UniProtKB/Swiss-Prot

Q2TGK0, Q923G5

UniProtKB/TrEMBL

A6IZL5, A6IZL6

Related

ENSRNOP00000023405.2, ENSRNOT00000023405.5

Conserved Domains (1) summary

pfam01529
Location:131 → 258

DHHC; DHHC palmitoyltransferase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086037.1 Reference GRCr8

Range

65048140..65065286 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039097438.2 → XP_038953366.1 palmitoyltransferase ZDHHC7 isoform X1

UniProtKB/Swiss-Prot

Q2TGK0, Q923G5

UniProtKB/TrEMBL

A6IZL5, A6IZL6

Conserved Domains (1) summary

pfam01529
Location:131 → 258

DHHC; DHHC palmitoyltransferase
XM_063277744.1 → XP_063133814.1 palmitoyltransferase ZDHHC7 isoform X1

UniProtKB/Swiss-Prot

Q2TGK0, Q923G5

UniProtKB/TrEMBL

A6IZL6