Cs citrate synthase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Csprovided by RGD
Official Full Name: citrate synthaseprovided by RGD
Primary source: RGD:620330
See related: EnsemblRapid:ENSRNOG00000023520 AllianceGenome:RGD:620330
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables citrate (Si)-synthase activity. Involved in several processes, including acetyl-CoA metabolic process; carboxylic acid metabolic process; and tricarboxylic acid cycle. Located in mitochondrion. Used to study congestive heart failure; hyperthyroidism; hypothyroidism; limb ischemia; and myocardial infarction. Biomarker of bipolar disorder and congestive heart failure. Human ortholog(s) of this gene implicated in dilated cardiomyopathy and hypertrophic cardiomyopathy. Orthologous to human CS (citrate synthase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 2316.4), Muscle (RPKM 1572.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q11

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (1348389..1374624)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (758074..791421)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (2752680..2778963)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The effects of exercise on skeletal and heart muscle citrate synthase and carnitine palmitoyltransferase mRNA expressions in high-calorie fed rats.
Title: The effects of exercise on skeletal and heart muscle citrate synthase and carnitine palmitoyltransferase mRNA expressions in high-calorie fed rats.
Our results indicate an alteration in the energy metabolism in hippocampus and striatum of infant rats after acute administration of l-tyrosine.
Title: Acute administration of l-tyrosine alters energetic metabolism of hippocampus and striatum of infant rats.
intermittent hypobaric hypoxia decreased myocardial citrate synthase activity and myoglobin and decreased myocardial lactate dehydrogenase activity
Title: Enzyme activity and myoglobin concentration in rat myocardium and skeletal muscles after passive intermittent simulated altitude exposure.
Citrate synthase activity is elevated in remnant glomeruli, and experimental models characterized by reduced glomerular citrate synthase activity (Wistar-Furth rats, adrenalectomized Sprague-Dawley rats) are protected from remnant nephropathy.
Title: Potential importance of glomerular citrate synthase activity in remnant nephropathy.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables acyltransferase activity, acyl groups converted into alkyl on transfer	ISO Inferred from Sequence Orthology more info
enables citrate (Si)-synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables citrate (Si)-synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables citrate (Si)-synthase activity	IEA Inferred from Electronic Annotation more info
enables citrate (Si)-synthase activity	ISO Inferred from Sequence Orthology more info
enables citrate (Si)-synthase activity	ISS Inferred from Sequence or Structural Similarity more info
enables citrate synthase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in acetyl-CoA metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in carbohydrate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in carbohydrate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in carbohydrate metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in citrate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in citrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in heart development	IEP Inferred from Expression Pattern more info	PubMed
involved_in oxaloacetate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in tricarboxylic acid cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in tricarboxylic acid cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in tricarboxylic acid cycle	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
located_in mitochondrial matrix	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: citrate synthase, mitochondrial

Names: citrate (Si)-synthase

NP_570111.1

EC 2.3.3.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_130755.1 → NP_570111.1 citrate synthase, mitochondrial precursor

See identical proteins and their annotated locations for NP_570111.1

Status: PROVISIONAL

Source sequence(s)

AF461496

UniProtKB/Swiss-Prot

Q8VHF5

UniProtKB/TrEMBL

G3V936

Related

ENSRNOP00000034921.5, ENSRNOT00000033726.7

Conserved Domains (2) summary

cd06105
Location:33 → 459

ScCit1-2_like; Saccharomyces cerevisiae (Sc) citrate synthases Cit1-2_like. Citrate synthases (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) with oxaloacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or ...

PLN02456
Location:29 → 454

PLN02456; citrate synthase