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pknox1.2 pbx/knotted 1 homeobox 1.2 [ Danio rerio (zebrafish) ]

Gene ID: 170445, updated on 17-Sep-2024

Summary

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Official Symbol
pknox1.2provided by ZNC
Official Full Name
pbx/knotted 1 homeobox 1.2provided by ZNC
Primary source
ZFIN:ZDB-GENE-020123-1
See related
Ensembl:ENSDARG00000036542 AllianceGenome:ZFIN:ZDB-GENE-020123-1
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
pbx; knotted; prep1.2
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within pharyngeal system development and retinoic acid receptor signaling pathway. Predicted to be located in nucleus. Is expressed in brain; head; neural tube; and pectoral fin. Orthologous to human PKNOX1 (PBX/knotted 1 homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See pknox1.2 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (46960233..46984123, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (46269001..46294636, complement)

Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene pyridoxal (pyridoxine, vitamin B6) kinase b Neighboring gene transmembrane serine protease 3b Neighboring gene si:dkey-22n8.3 Neighboring gene intersectin 1 (SH3 domain protein)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. prep1.2 and aldh1a2 participate to a positive loop required for branchial arches development in zebrafish. Vaccari E, et al. Dev Biol, 2010 Jul 1. PMID 20423710
  2. The Hox cofactors Meis1 and Pbx act upstream of gata1 to regulate primitive hematopoiesis. Pillay LM, et al. Dev Biol, 2010 Apr 15. PMID 20123093
  3. Pbx acts with Hand2 in early myocardial differentiation. Maves L, et al. Dev Biol, 2009 Sep 15. PMID 19607825, Free PMC Article
  4. Coordinate regulation of retinoic acid synthesis by pbx genes and fibroblast growth factor signaling by hoxb1b is required for hindbrain patterning and development. Selland LG, et al. Mech Dev, 2018 Apr. PMID 29496480
  5. Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. Diotel N, et al. J Comp Neurol, 2015 Jun 1. PMID 25556858, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Loss of hoxb1b together with pbx4 reverts the hindbrain to a groundstate identity, demonstrating the importance of hox genes in patterning nearly the entire hindbrain, and a key requirement for Pbx in this process. Additionally, we provide evidence that while pbx genes regulate RA signaling, hoxb1b regulates hindbrain identity through complex regulation of FGF signaling
    Title: Coordinate regulation of retinoic acid synthesis by pbx genes and fibroblast growth factor signaling by hoxb1b is required for hindbrain patterning and development.
  2. prep1.2 participate to a positive loop required for branchial arches development in zebrafish
    Title: prep1.2 and aldh1a2 participate to a positive loop required for branchial arches development in zebrafish.
  3. The Hox cofactor pbx acts upstream of gata1 to regulate primitive hematopoiesis.
    Title: The Hox cofactors Meis1 and Pbx act upstream of gata1 to regulate primitive hematopoiesis.
  4. Pbx acts with Hand2 in early myocardial differentiation
    Title: Pbx acts with Hand2 in early myocardial differentiation.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within pharyngeal system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within retinoic acid receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
homeobox protein PKNOX1; pbx/knotted 1 homeobox 1.2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007112.7 Reference GRCz11 Primary Assembly

    Range
    46960233..46984123 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009294000.4 → XP_009292275.1  homeobox protein PKNOX1

    See identical proteins and their annotated locations for XP_009292275.1

    UniProtKB/TrEMBL
    A0A8N7TEV4, E7FBG0
    Related
    ENSDARP00000110278.1, ENSDART00000130607.3
    Conserved Domains (2) summary
    pfam05920
    Location:293 → 332
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:91 → 175
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

  2. XM_702776.8 → XP_707868.2  homeobox protein PKNOX1

    See identical proteins and their annotated locations for XP_707868.2

    UniProtKB/TrEMBL
    A0A8N7TEV4, E7FBG0
    Conserved Domains (2) summary
    pfam05920
    Location:293 → 332
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:91 → 175
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

  3. XM_068221694.1 → XP_068077795.1  homeobox protein PKNOX1

  4. XM_068221696.1 → XP_068077797.1  homeobox protein PKNOX1

  5. XM_068221695.1 → XP_068077796.1  homeobox protein PKNOX1

  6. XM_068221700.1 → XP_068077801.1  homeobox protein PKNOX1

Nucleotide Protein Strain
Heading Accession and Version

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