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Lasp1 LIM and SH3 protein 1 [ Mus musculus (house mouse) ]

Gene ID: 16796, updated on 2-Nov-2024

Summary

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Official Symbol
Lasp1provided by MGI
Official Full Name
LIM and SH3 protein 1provided by MGI
Primary source
MGI:MGI:109656
See related
Ensembl:ENSMUSG00000038366 AllianceGenome:MGI:109656
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Def-4; SH3P6; LASP-1; MLN 50; Tg(Col1a1-lacZ)1Ngma
Summary
Enables actin filament binding activity. Predicted to be involved in monoatomic ion transport. Located in cytoplasm and focal adhesion. Is expressed in several structures, including alimentary system; bone; central nervous system; genitourinary system; and hemolymphoid system gland. Orthologous to human LASP1 (LIM and SH3 protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in large intestine adult (RPKM 112.9), duodenum adult (RPKM 108.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Lasp1 in Genome Data Viewer
Location:
11 D; 11 61.1 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (97689748..97729591)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (97799005..97838765)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5272 Neighboring gene ribosomal protein L23 Neighboring gene small nucleolar RNA, H/ACA box 21 Neighboring gene STARR-seq mESC enhancer starr_30635 Neighboring gene STARR-positive B cell enhancer ABC_E7052 Neighboring gene nuclear encoded tRNA cysteine 56 (anticodon GCA) Neighboring gene nuclear encoded tRNA cysteine 51 (anticodon GCA) Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:97669517-97669700 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:97686746-97686855 Neighboring gene RIKEN cDNA B230217C12 gene Neighboring gene STARR-seq mESC enhancer starr_30642 Neighboring gene F-box protein 47 Neighboring gene STARR-seq mESC enhancer starr_30643 Neighboring gene STARR-positive B cell enhancer ABC_E3011

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Targeted disruption of the Lasp-1 gene is linked to increases in histamine-stimulated gastric HCl secretion. Chew CS, et al. Am J Physiol Gastrointest Liver Physiol, 2008 Jul. PMID 18483181, Free PMC Article
  2. Hippocampal LASP1 ameliorates chronic stress-mediated behavioral responses in a mouse model of unpredictable chronic mild stress. Cui YH, et al. Neuropharmacology, 2021 Feb 15. PMID 33242526
  3. Regulation of cell migration and survival by focal adhesion targeting of Lasp-1. Lin YH, et al. J Cell Biol, 2004 May 10. PMID 15138294, Free PMC Article
  4. Chromosomal assignment and expression pattern of the murine Lasp-1 gene. Schreiber V, et al. Gene, 1998 Jan 30. PMID 9511759
  5. Lasp1 gene disruption is linked to enhanced cell migration and tumor formation. Zhang H, et al. Physiol Genomics, 2009 Aug 7. PMID 19531578, Free PMC Article

See all (60) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cholesterol uptake in the intestine is regulated by the LASP1-AKT-NPC1L1 signaling pathway.
    Title: Cholesterol uptake in the intestine is regulated by the LASP1-AKT-NPC1L1 signaling pathway.
  2. Silenced LASP1 interacts with DNMT1 to promote TJP2 expression and attenuate articular cartilage injury in mice by suppressing TJP2 methylation.
    Title: Silenced LASP1 interacts with DNMT1 to promote TJP2 expression and attenuate articular cartilage injury in mice by suppressing TJP2 methylation.
  3. Hippocampal LASP1 ameliorates chronic stress-mediated behavioral responses in a mouse model of unpredictable chronic mild stress.
    Title: Hippocampal LASP1 ameliorates chronic stress-mediated behavioral responses in a mouse model of unpredictable chronic mild stress.
  4. Lasp1 regulates adherens junction dynamics and fibroblast transformation in destructive arthritis.
    Title: Lasp1 regulates adherens junction dynamics and fibroblast transformation in destructive arthritis.
  5. Results defined LASP1 as a direct target gene for HIF1alpha upregulation that is critical for metastatic progression of PDAC.
    Title: LASP1 is a HIF1α target gene critical for metastasis of pancreatic cancer.
  6. Data show that MEFs derived from Lasp1(-/-) mice migrated more rapidly in vitro.
    Title: Lasp1 gene disruption is linked to enhanced cell migration and tumor formation.
  7. role of Lasp1 in chondrocyte differentiation during cartilage to bone transition
    Title: Lasp1 misexpression influences chondrocyte differentiation in the vertebral column.
  8. The role of Lasp1 in the regulation of hydrochloride secretion in vivo was studied in a murine model with a targeted disruption of the Lasp-1 gene.
    Title: Targeted disruption of the Lasp-1 gene is linked to increases in histamine-stimulated gastric HCl secretion.
  9. LIM-nebulette, Lasp-1, and zyxin may play an important role in the organization of focal adhesions
    Title: Zyxin interacts with the SH3 domains of the cytoskeletal proteins LIM-nebulette and Lasp-1.
  10. Lasp-1 is a dynamic focal adhesion protein necessary for cell migration and survival in response to growth factors and ECM proteins.
    Title: Regulation of cell migration and survival by focal adhesion targeting of Lasp-1.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (2) 
  • Targeted (1)  1 citation
  • Transgenic (1)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin filament binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monoatomic ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables monoatomic ion transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transport ISO
Inferred from Sequence Orthology
more info
  
involved_in monoatomic ion transport ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cortical actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in cortical actin cytoskeleton ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in focal adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
LIM and SH3 domain protein 1
Names
Tg(11Col1a1)NG
metastatic lymph node gene 50 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001433277.1 → NP_001420206.1  LIM and SH3 domain protein 1

    Status: VALIDATED

    Source sequence(s)
    AL596446
    UniProtKB/Swiss-Prot
    Q61792, Q62416
    UniProtKB/TrEMBL
    Q543N3

  2. NM_010688.5 → NP_034818.1  LIM and SH3 domain protein 1

    See identical proteins and their annotated locations for NP_034818.1

    Status: VALIDATED

    Source sequence(s)
    AL596446, BE955478
    Consensus CDS
    CCDS25332.1
    UniProtKB/Swiss-Prot
    Q61792, Q62416
    UniProtKB/TrEMBL
    Q543N3
    Related
    ENSMUSP00000042123.6, ENSMUST00000043843.12
    Conserved Domains (3) summary
    smart00227
    Location:98 → 128
    NEBU; The Nebulin repeat is present also in Las1
    cd09447
    Location:5 → 57
    LIM_LASP; The LIM domain of LIM and SH3 Protein (LASP)
    cd11934
    Location:205 → 263
    SH3_Lasp1_C; C-terminal Src Homology 3 domain of LIM and SH3 domain protein 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    97689748..97729591
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532341.2 → XP_006532404.1  LIM and SH3 domain protein 1 isoform X1

    Conserved Domains (3) summary
    smart00227
    Location:98 → 128
    NEBU; The Nebulin repeat is present also in Las1
    cd09447
    Location:5 → 57
    LIM_LASP; The LIM domain of LIM and SH3 Protein (LASP)
    cd11934
    Location:205 → 263
    SH3_Lasp1_C; C-terminal Src Homology 3 domain of LIM and SH3 domain protein 1

  2. XM_006532342.1 → XP_006532405.1  LIM and SH3 domain protein 1 isoform X2

    UniProtKB/TrEMBL
    A2A6H0
    Related
    ENSMUSP00000123050.2, ENSMUST00000148280.3
    Conserved Domains (3) summary
    smart00227
    Location:62 → 92
    NEBU; The Nebulin repeat is present also in Las1
    cd11934
    Location:169 → 227
    SH3_Lasp1_C; C-terminal Src Homology 3 domain of LIM and SH3 domain protein 1
    cl02475
    Location:1 → 21
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61792.1 GenPept UniProtKB/Swiss-Prot:Q61792

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