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Klc2 kinesin light chain 2 [ Mus musculus (house mouse) ]

Gene ID: 16594, updated on 2-Nov-2024

Summary

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Official Symbol
Klc2provided by MGI
Official Full Name
kinesin light chain 2provided by MGI
Primary source
MGI:MGI:107953
See related
Ensembl:ENSMUSG00000024862 AllianceGenome:MGI:107953
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
KLC 2; KLC-2; 8030455F02Rik
Summary
Enables kinesin binding activity. Acts upstream of or within axo-dendritic transport. Located in ciliary rootlet; cytosol; and neuron projection. Part of kinesin complex. Used to study nonsyndromic deafness. Human ortholog(s) of this gene implicated in SPOAN syndrome. Orthologous to human KLC2 (kinesin light chain 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in cerebellum adult (RPKM 59.4), cortex adult (RPKM 42.0) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Klc2 in Genome Data Viewer
Location:
19 A; 19 4.25 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (5157774..5168326, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (5107746..5118298, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene Yip1 interacting factor homolog A (S. cerevisiae) Neighboring gene cornichon family AMPA receptor auxiliary protein 2 Neighboring gene RAB1B, member RAS oncogene family Neighboring gene STARR-positive B cell enhancer ABC_E1969 Neighboring gene predicted gene, 30840 Neighboring gene heterogeneous nuclear ribonucleoprotein F pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Deficiency of Klc2 Induces Low-Frequency Sensorineural Hearing Loss in C57BL/6 J Mice and Human. Fu X, et al. Mol Neurobiol, 2021 Sep. PMID 34014435
  2. Structural plasticity of the N-terminal capping helix of the TPR domain of kinesin light chain. Nguyen TQ, et al. PLoS One, 2017. PMID 29036226, Free PMC Article
  3. Structural basis for kinesin-1:cargo recognition. Pernigo S, et al. Science, 2013 Apr 19. PMID 23519214, Free PMC Article
  4. Sequence analysis of the ERCC2 gene regions in human, mouse, and hamster reveals three linked genes. Lamerdin JE, et al. Genomics, 1996 Jun 15. PMID 8786141
  5. A kinesin signaling complex mediates the ability of GSK-3beta to affect mood-associated behaviors. Du J, et al. Proc Natl Acad Sci U S A, 2010 Jun 22. PMID 20534517, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Deficiency of Klc2 Induces Low-Frequency Sensorineural Hearing Loss in C57BL/6 J Mice and Human.
    Title: Deficiency of Klc2 Induces Low-Frequency Sensorineural Hearing Loss in C57BL/6 J Mice and Human.
  2. structural plasticity of the N-terminal capping helix might represent a structural determinant for TPR domain structural versatility in cargo binding
    Title: Structural plasticity of the N-terminal capping helix of the TPR domain of kinesin light chain.
  3. KLC2 is a cellular target of GSK-3beta capable of regulating synaptic plasticity, particularly AMPA receptor trafficking, as well as mood-associated behaviors in animal models
    Title: A kinesin signaling complex mediates the ability of GSK-3beta to affect mood-associated behaviors.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1)  1 citation
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables kinesin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kinesin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within axo-dendritic transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lysosome localization ISO
Inferred from Sequence Orthology
more info
  
involved_in lysosome localization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule-based movement TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in ciliary rootlet IDA
Inferred from Direct Assay
more info
 PubMed 
located_in ciliary rootlet IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of kinesin complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in neuron projection IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
kinesin light chain 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001369360.1 → NP_001356289.1  kinesin light chain 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC124502
    Consensus CDS
    CCDS37889.1
    UniProtKB/TrEMBL
    D3YXZ3, Q91YS4
    Related
    ENSMUSP00000025798.7, ENSMUST00000025798.13
    Conserved Domains (3) summary
    TIGR02168
    Location:9 → 139
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:282 → 310
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:238 → 314
    TPR_12; Tetratricopeptide repeat

  2. NM_001369361.1 → NP_001356290.1  kinesin light chain 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC124502
    UniProtKB/TrEMBL
    D3YXZ3
    Conserved Domains (3) summary
    TIGR02168
    Location:9 → 139
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:282 → 310
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:238 → 314
    TPR_12; Tetratricopeptide repeat

  3. NM_001369362.1 → NP_001356291.1  kinesin light chain 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC124502
    UniProtKB/TrEMBL
    D3YXZ3
    Conserved Domains (3) summary
    TIGR02168
    Location:9 → 139
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:282 → 310
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:238 → 314
    TPR_12; Tetratricopeptide repeat

  4. NM_008451.3 → NP_032477.2  kinesin light chain 2 isoform 1

    See identical proteins and their annotated locations for NP_032477.2

    Status: VALIDATED

    Source sequence(s)
    AC124502
    Consensus CDS
    CCDS37889.1
    UniProtKB/TrEMBL
    D3YXZ3, Q91YS4
    Related
    ENSMUSP00000112262.2, ENSMUST00000116563.8
    Conserved Domains (3) summary
    TIGR02168
    Location:9 → 139
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:282 → 310
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:238 → 314
    TPR_12; Tetratricopeptide repeat

RNA

  1. NR_045528.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC124502

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    5157774..5168326 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O88448.1 GenPept UniProtKB/Swiss-Prot:O88448

Gene LinkOut

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