Itgam integrin alpha M [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Itgamprovided by MGI
Official Full Name: integrin alpha Mprovided by MGI
Primary source: MGI:MGI:96607
See related: Ensembl:ENSMUSG00000030786 AllianceGenome:MGI:96607
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CR3; CR3A; MAC1; Cd11b; Ly-40; Mac-1; Mac-1a; CD11b/CD18; F730045J24Rik
Summary: Enables complement component C3b binding activity; heparan sulfate proteoglycan binding activity; and heparin binding activity. Contributes to cargo receptor activity. Involved in several processes, including central nervous system development; complement-mediated synapse pruning; and endocytosis. Acts upstream of or within several processes, including activated T cell proliferation; microglia development; and neutrophil chemotaxis. Located in external side of plasma membrane and nucleus. Part of integrin alphaM-beta2 complex. Is expressed in several structures, including central nervous system; heart; hemolymphoid system; renal interstitium; and yolk sac. Human ortholog(s) of this gene implicated in lupus nephritis; persistent fetal circulation syndrome; and pre-eclampsia. Orthologous to human ITGAM (integrin subunit alpha M). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in liver E18 (RPKM 8.3), mammary gland adult (RPKM 7.7) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F3; 7 69.93 cM

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (127661812..127717663)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (128062640..128118491)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deletion of Tmem268 in mice suppresses anti-infectious immune responses by downregulating CD11b signaling.
Title: Deletion of Tmem268 in mice suppresses anti-infectious immune responses by downregulating CD11b signaling.
The integrin CD11b inhibits MSU-induced NLRP3 inflammasome activation in macrophages and protects mice against MSU-induced joint inflammation.
Title: The integrin CD11b inhibits MSU-induced NLRP3 inflammasome activation in macrophages and protects mice against MSU-induced joint inflammation.
Endoplasmic Reticulum Protein 72 Regulates Integrin Mac-1 Activity to Influence Neutrophil Recruitment.
Title: Endoplasmic Reticulum Protein 72 Regulates Integrin Mac-1 Activity to Influence Neutrophil Recruitment.
Mac-1 deficiency ameliorates pressure overloaded heart failure through inhibiting macrophage polarization and activation.
Title: Mac-1 deficiency ameliorates pressure overloaded heart failure through inhibiting macrophage polarization and activation.
Impact of surface receptors TLR2, CR3, and FcgammaRIII on Rhodococcus equi phagocytosis and intracellular survival in macrophages.
Title: Impact of surface receptors TLR2, CR3, and FcγRIII on Rhodococcus equi phagocytosis and intracellular survival in macrophages.
CD11b mediates hypertensive cardiac remodeling by regulating macrophage infiltration and polarization.
Title: CD11b mediates hypertensive cardiac remodeling by regulating macrophage infiltration and polarization.
Escherichia coli adhesion protein FimH exacerbates colitis via CD11b[+]CD103[-] dendritic cell activation.
Title: Escherichia coli adhesion protein FimH exacerbates colitis via CD11b(+)CD103(-) dendritic cell activation.
Toll-like receptor 4 and CD11b expressed on microglia coordinate eradication of Candida albicans cerebral mycosis.
Title: Toll-like receptor 4 and CD11b expressed on microglia coordinate eradication of Candida albicans cerebral mycosis.
B-cell receptor associated protein 31 deficiency decreases the expression of adhesion molecule CD11b/CD18 and PSGL-1 in neutrophils to ameliorate acute lung injury.
Title: B-cell receptor associated protein 31 deficiency decreases the expression of adhesion molecule CD11b/CD18 and PSGL-1 in neutrophils to ameliorate acute lung injury.
Complement C3 Enhances LPS-Elicited Neuroinflammation and Neurodegeneration Via the Mac1/NOX2 Pathway.
Title: Complement C3 Enhances LPS-Elicited Neuroinflammation and Neurodegeneration Via the Mac1/NOX2 Pathway.

Submit: New GeneRIF Correction See all GeneRIFs (249)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (3)
Endonuclease-mediated (6) 1 citation
Gene trapped (1)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Itgam (e-PCR), detects polymorphism
- UniSTS:143626

NoName (e-PCR)
- UniSTS:484904

Itgam (e-PCR), detects polymorphism
- UniSTS:256396

Itgam (e-PCR), detects polymorphism
- UniSTS:516503

PMC27130P4 (e-PCR)
- UniSTS:272378

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cargo receptor activity	IGI Inferred from Genetic Interaction more info	PubMed
contributes_to cargo receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables complement component C3b binding	IGI Inferred from Genetic Interaction more info	PubMed
enables heat shock protein binding	ISO Inferred from Sequence Orthology more info
enables heparan sulfate proteoglycan binding	IDA Inferred from Direct Assay more info	PubMed
enables heparin binding	IDA Inferred from Direct Assay more info	PubMed
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables opsonin binding	IDA Inferred from Direct Assay more info	PubMed
enables opsonin binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within activated T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in amyloid-beta clearance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in amyloid-beta clearance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell adhesion	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell adhesion mediated by integrin	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell-cell adhesion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular extravasation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in complement receptor mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in complement-mediated synapse pruning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in forebrain development	IDA Inferred from Direct Assay more info	PubMed
involved_in integrin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in integrin-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in leukocyte adhesion to vascular endothelial cell	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within leukocyte cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within leukocyte migration involved in inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within microglia development	IDA Inferred from Direct Assay more info	PubMed
involved_in microglial cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of dopamine metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in neutrophil apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neutrophil chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phagocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phagocytosis, engulfment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mast cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of microglial cell mediated cytotoxicity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neutrophil degranulation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of prostaglandin-E synthase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein targeting to membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of superoxide anion generation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of superoxide anion generation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of superoxide anion generation	ISO Inferred from Sequence Orthology more info
involved_in receptor-mediated endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vertebrate eye-specific patterning	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of integrin alphaM-beta2 complex	IMP Inferred from Mutant Phenotype more info	PubMed
part_of integrin alphaM-beta2 complex	ISO Inferred from Sequence Orthology more info
part_of integrin complex	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane raft	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane raft	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: integrin alpha-M

Names: CD11 antigen-like family member B; CD11B (p170); CR-3 alpha chain; Mac-1 alpha; cell surface glycoprotein MAC-1 alpha subunit; cell surface glycoprotein MAC-1 subunit alpha; complement receptor type 3; leukocyte adhesion receptor MO1; macrophage antigen alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001082960.1 → NP_001076429.1 integrin alpha-M isoform 1 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (1) is the longer transcript and encodes the longer protein (isoform 1).

Source sequence(s)

AC093175, AC124566

Consensus CDS

CCDS40149.1

UniProtKB/TrEMBL

G5E8F1, Q3TD86, Q3U4I5

Related

ENSMUSP00000068468.9, ENSMUST00000064821.14

Conserved Domains (4) summary

smart00191
Location:517 → 558

Int_alpha; Integrin alpha (beta-propellor repeats)

cd01469
Location:149 → 324

vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...

pfam00357
Location:1131 → 1143

Integrin_alpha; Integrin alpha cytoplasmic region

pfam08441
Location:615 → 1034

Integrin_alpha2; Integrin alpha
NM_008401.2 → NP_032427.2 integrin alpha-M isoform 2 precursor

See identical proteins and their annotated locations for NP_032427.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1, resulting in a shorter protein (isoform 2).

Source sequence(s)

AC093175, AC124566

Consensus CDS

CCDS21889.1

UniProtKB/TrEMBL

E9Q604, Q3TD86, Q3U4I5

Related

ENSMUSP00000101849.5, ENSMUST00000106242.10

Conserved Domains (4) summary

smart00191
Location:516 → 557

Int_alpha; Integrin alpha (beta-propellor repeats)

cd01469
Location:149 → 324

vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...

pfam00357
Location:1130 → 1142

Integrin_alpha; Integrin alpha cytoplasmic region

pfam08441
Location:614 → 1033

Integrin_alpha2; Integrin alpha