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SPICE1 spindle and centriole associated protein 1 [ Homo sapiens (human) ]

Gene ID: 152185, updated on 28-Oct-2024

Summary

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Official Symbol
SPICE1provided by HGNC
Official Full Name
spindle and centriole associated protein 1provided by HGNC
Primary source
HGNC:HGNC:25083
See related
Ensembl:ENSG00000163611 MIM:613447; AllianceGenome:HGNC:25083
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SPICE; CCDC52
Summary
Involved in metaphase chromosome alignment; mitotic spindle assembly; and regulation of centriole replication. Located in centriole; centrosome; and spindle. [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in testis (RPKM 3.6), endometrium (RPKM 3.3) and 25 other tissues See more
Orthologs
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Genomic context

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See SPICE1 in Genome Data Viewer
Location:
3q13.2
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (113442718..113515156, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (116163861..116236319, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (113161565..113234003, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene SPICE1-CFAP44 readthrough (NMD candidate) Neighboring gene cilia and flagella associated protein 44 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:113085321-113085822 Neighboring gene RABGGTB pseudogene 1 Neighboring gene Sharpr-MPRA regulatory region 3247 Neighboring gene PHF5A pseudogene 2 Neighboring gene CFAP44 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20251 Neighboring gene microRNA 8076 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:113176937-113177646 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:113177647-113178356 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20252 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20253 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20254 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20255 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20256 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20257 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20258 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20259 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14606 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20260 Neighboring gene SID1 transmembrane family member 1 Neighboring gene SIDT1 antisense RNA 1 Neighboring gene microRNA 4446

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. SPICE--a previously uncharacterized protein required for centriole duplication and mitotic chromosome congression. Archinti M, et al. J Cell Sci, 2010 Sep 15. PMID 20736305
  2. CEP120 and SPICE1 cooperate with CPAP in centriole elongation. Comartin D, et al. Curr Biol, 2013 Jul 22. PMID 23810536
  3. A rapid computational approach identifies SPICE1 as an Aurora kinase substrate. Deretic J, et al. Mol Biol Cell, 2019 Feb 1. PMID 30485161, Free PMC Article
  4. Purification of CpG islands using a methylated DNA binding column. Cross SH, et al. Nat Genet, 1994 Mar. PMID 8012384
  5. Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation. Fan X, et al. Stem Cell Res Ther, 2021 Feb 4. PMID 33541421, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Potential readthrough

Included gene: CFAP44

Readthrough SPICE1-CFAP44

Readthrough gene: SPICE1-CFAP44, Included gene: CFAP44

Homology

Clone Names

  • FLJ26064, FLJ44949

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in metaphase chromosome alignment IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in metaphase chromosome alignment IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of centriole replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of centriole replication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in centriole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centriole IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in spindle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
spindle and centriole-associated protein 1
Names
coiled-coil domain-containing protein 52

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001331078.2 → NP_001318007.1  spindle and centriole-associated protein 1

    Status: VALIDATED

    Source sequence(s)
    AC112128
    Consensus CDS
    CCDS2973.1
    UniProtKB/Swiss-Prot
    D3DN72, Q8N0Z3, Q8WUX6
    Conserved Domains (1) summary
    pfam15678
    Location:36 → 434
    SPICE; Centriole duplication and mitotic chromosome congression

  2. NM_001331079.2 → NP_001318008.2  spindle and centriole-associated protein 1

    Status: VALIDATED

    Source sequence(s)
    AC112128
    Consensus CDS
    CCDS2973.1
    UniProtKB/Swiss-Prot
    D3DN72, Q8N0Z3, Q8WUX6
    Conserved Domains (1) summary
    pfam15678
    Location:36 → 434
    SPICE; Centriole duplication and mitotic chromosome congression

  3. NM_001387939.1 → NP_001374868.1  spindle and centriole-associated protein 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents the longest transcript. Variants 1-4 all encode the same protein.
    Source sequence(s)
    AC112128
    Consensus CDS
    CCDS2973.1
    UniProtKB/Swiss-Prot
    D3DN72, Q8N0Z3, Q8WUX6
    Conserved Domains (1) summary
    pfam15678
    Location:36 → 434
    SPICE; Centriole duplication and mitotic chromosome congression

  4. NM_144718.4 → NP_653319.1  spindle and centriole-associated protein 1

    See identical proteins and their annotated locations for NP_653319.1

    Status: VALIDATED

    Source sequence(s)
    AC112128, AY099107, BP278430, U79249
    Consensus CDS
    CCDS2973.1
    UniProtKB/Swiss-Prot
    D3DN72, Q8N0Z3, Q8WUX6
    Related
    ENSP00000295872.4, ENST00000295872.8
    Conserved Domains (1) summary
    pfam15678
    Location:36 → 434
    SPICE; Centriole duplication and mitotic chromosome congression

RNA

  1. NR_170870.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC112128

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    113442718..113515156 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    116163861..116236319 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N0Z3.1 GenPept UniProtKB/Swiss-Prot:Q8N0Z3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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