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NEK10 NIMA related kinase 10 [ Homo sapiens (human) ]

Gene ID: 152110, updated on 14-Nov-2024

Summary

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Official Symbol
NEK10provided by HGNC
Official Full Name
NIMA related kinase 10provided by HGNC
Primary source
HGNC:HGNC:18592
See related
Ensembl:ENSG00000163491 MIM:618726; AllianceGenome:HGNC:18592
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CILD44
Summary
Enables protein kinase activity. Involved in several processes, including mucociliary clearance; positive regulation of protein phosphorylation; and regulation of ERK1 and ERK2 cascade. Part of protein kinase complex. Implicated in primary ciliary dyskinesia 44. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis (RPKM 2.8), brain (RPKM 0.3) and 6 other tissues See more
Orthologs
mouse all
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Genomic context

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See NEK10 in Genome Data Viewer
Location:
3p24.1
Exon count:
47
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (27106484..27369383, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (27108644..27371532, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (27147975..27410874, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:26663597-26664112 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:26665705-26666674 Neighboring gene LRRC3B antisense RNA 1 Neighboring gene uncharacterized LOC124909488 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:26727688-26727896 Neighboring gene leucine rich repeat containing 3B Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:26824284-26824877 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:26824878-26825470 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19615 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:27083978-27084542 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:27085107-27085671 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:27084543-27085106 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:27141697-27142896 Neighboring gene NANOG hESC enhancer GRCh37_chr3:27147157-27147736 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14148 Neighboring gene MPRA-validated peak4579 silencer Neighboring gene MICOS10 pseudogene 3 Neighboring gene RNA, U6 small nuclear 342, pseudogene Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:27352339-27353538 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:27410132-27410632 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:27483819-27484320 Neighboring gene solute carrier family 4 member 7 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:27505552-27506411 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:27513115-27513615 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19616 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19617 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19618 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:27525149-27525925 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19619 Neighboring gene ribosomal protein S20 pseudogene 15 Neighboring gene ubiquitin A-52 residue ribosomal protein fusion product 1 pseudogene 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Homozygous truncating NEK10 mutation, associated with primary ciliary dyskinesia: a case report. Al Mutairi F, et al. BMC Pulm Med, 2020 May 15. PMID 32414360, Free PMC Article
  2. A human ciliopathy reveals essential functions for NEK10 in airway mucociliary clearance. Chivukula RR, et al. Nat Med, 2020 Feb. PMID 31959991, Free PMC Article
  3. β-catenin turnover is regulated by Nek10-mediated tyrosine phosphorylation in A549 lung adenocarcinoma cells. Dutt P, et al. Proc Natl Acad Sci U S A, 2024 May 7. PMID 38683979, Free PMC Article
  4. NEK10 tyrosine phosphorylates p53 and controls its transcriptional activity. Haider N, et al. Oncogene, 2020 Jul. PMID 32561851
  5. Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2. Ahmed S, et al. Nat Genet, 2009 May. PMID 19330027, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. beta-catenin turnover is regulated by Nek10-mediated tyrosine phosphorylation in A549 lung adenocarcinoma cells.
    Title: β-catenin turnover is regulated by Nek10-mediated tyrosine phosphorylation in A549 lung adenocarcinoma cells.
  2. Homozygous truncating NEK10 mutation, associated with primary ciliary dyskinesia: a case report.
    Title: Homozygous truncating NEK10 mutation, associated with primary ciliary dyskinesia: a case report.
  3. NEK10 tyrosine phosphorylates p53 and controls its transcriptional activity.
    Title: NEK10 tyrosine phosphorylates p53 and controls its transcriptional activity.
  4. analysis of a bronchiectasis syndrome caused by mutations that inactivate NIMA-related kinase 10 (NEK10), a protein kinase with previously unknown in vivo functions in mammals
    Title: A human ciliopathy reveals essential functions for NEK10 in airway mucociliary clearance.
  5. Nek10 physically associated with Raf-1 and MEK1 in a Raf-1-dependent manner, and the formation of this complex was necessary for Nek10-mediated MEK1 activation.
    Title: Nek10 mediates G2/M cell cycle arrest and MEK autoactivation in response to UV irradiation.
  6. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  7. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Common genetic variants associated with breast cancer and mammographic density measures that predict disease.
  8. Observational study of gene-disease association. (HuGE Navigator)
    Title: Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Ciliary dyskinesia, primary, 44
MedGen: C5394063 OMIM: 618781 GeneReviews: Not available
not available

EBI GWAS Catalog

Description
A genome-wide association study of early-onset breast cancer identifies PFKM as a novel breast cancer gene and supports a common genetic spectrum for breast cancer at any age.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ32685

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 3-phosphoinositide-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables AMP-activated protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables Rho-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables eukaryotic translation initiation factor 2alpha kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS121 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AT120 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AXS139 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2BS14 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2BS36 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S10 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S28 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S57 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T11 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T3 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T45 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T6 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H4S1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribosomal protein S6 kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in mucociliary clearance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of MAP kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein autophosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell cycle G2/M phase transition IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell cycle G2/M phase transition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
part_of protein kinase complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
serine/threonine-protein kinase Nek10
Names
NIMA (never in mitosis gene a)- related kinase 10
never in mitosis A-related kinase 10
nimA-related protein kinase 10
NP_001026911.1
NP_001291313.1
NP_001381892.1
NP_001381893.1
NP_001381894.1
NP_001381895.1
NP_001381896.1
NP_001381897.1
NP_001381898.1
NP_001381899.1
NP_001381900.1
NP_689747.3
NP_955379.2
XP_006713061.1
XP_006713062.1
XP_006713064.1
XP_011531716.1
XP_016861251.1
XP_016861252.1
XP_016861253.1
XP_016861254.1
XP_016861257.1
XP_016861263.1
XP_047303461.1
XP_047303462.1
XP_047303463.1
XP_047303464.1
XP_047303465.1
XP_047303466.1
XP_047303467.1
XP_047303468.1
XP_054201339.1
XP_054201340.1
XP_054201341.1
XP_054201342.1
XP_054201343.1
XP_054201344.1
XP_054201345.1
XP_054201346.1
XP_054201347.1
XP_054201348.1
XP_054201349.1
XP_054201350.1
XP_054201351.1
XP_054201352.1
XP_054201353.1
XP_054201354.1
XP_054201355.1
XP_054201356.1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031741.5 → NP_001026911.1  serine/threonine-protein kinase Nek10 isoform 1

    See identical proteins and their annotated locations for NP_001026911.1

    Status: VALIDATED

    Source sequence(s)
    AC093555, AC098931
    Related
    ENSP00000373281.4, ENST00000383771.8
    Conserved Domains (1) summary
    cl21453
    Location:10 → 97
    PKc_like; Protein Kinases, catalytic domain

  2. NM_001304384.3 → NP_001291313.1  serine/threonine-protein kinase Nek10 isoform 4

    See identical proteins and their annotated locations for NP_001291313.1

    Status: VALIDATED

    Source sequence(s)
    AC093555, AC098931
    Consensus CDS
    CCDS77713.1
    Related
    ENSP00000295720.6, ENST00000295720.10
    Conserved Domains (1) summary
    cl21453
    Location:10 → 97
    PKc_like; Protein Kinases, catalytic domain

  3. NM_001394963.1 → NP_001381892.1  serine/threonine-protein kinase Nek10 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC093555, AC098931, AC099535
    UniProtKB/TrEMBL
    A0A650C2D3
    Conserved Domains (1) summary
    cd08528
    Location:518 → 785
    STKc_Nek10; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 10

  4. NM_001394964.1 → NP_001381893.1  serine/threonine-protein kinase Nek10 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC093555, AC098931, AC099535
    UniProtKB/TrEMBL
    A0A650C2D3
    Conserved Domains (1) summary
    cd08528
    Location:489 → 756
    STKc_Nek10; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 10

  5. NM_001394965.1 → NP_001381894.1  serine/threonine-protein kinase Nek10 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC093555, AC098931, AC099535
    UniProtKB/TrEMBL
    A0A650C2C8, A0A650C2D3
    Conserved Domains (1) summary
    cd08528
    Location:518 → 785
    STKc_Nek10; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 10

  6. NM_001394966.1 → NP_001381895.1  serine/threonine-protein kinase Nek10 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC093555, AC098931, AC099535
    Consensus CDS
    CCDS93229.1
    UniProtKB/TrEMBL
    A0A650C2D3, A0A8I5KTB8
    Related
    ENSP00000509472.1, ENST00000691995.1
    Conserved Domains (1) summary
    cd08528
    Location:518 → 785
    STKc_Nek10; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 10

  7. NM_001394967.1 → NP_001381896.1  serine/threonine-protein kinase Nek10 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC093555, AC098931, AC099535
    UniProtKB/TrEMBL
    A0A650C2D3
    Conserved Domains (1) summary
    cd08528
    Location:489 → 756
    STKc_Nek10; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 10

  8. NM_001394968.1 → NP_001381897.1  serine/threonine-protein kinase Nek10 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC093555, AC098931, AC099535
    UniProtKB/TrEMBL
    A0A650C2D3
    Conserved Domains (1) summary
    cl21453
    Location:525 → 746
    PKc_like; Protein Kinases, catalytic domain

  9. NM_001394969.1 → NP_001381898.1  serine/threonine-protein kinase Nek10 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC093555, AC098931, AC099535
    UniProtKB/TrEMBL
    A0A650C2D3
    Conserved Domains (1) summary
    cl21453
    Location:489 → 689
    PKc_like; Protein Kinases, catalytic domain

  10. NM_001394970.1 → NP_001381899.1  serine/threonine-protein kinase Nek10 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC093555, AC098931, AC099535
    UniProtKB/Swiss-Prot
    A8MWG1, B9ZVR0, Q45VJ4, Q6ZR11, Q6ZWH5, Q7Z671, Q86XB1, Q96MB3
    UniProtKB/TrEMBL
    A0A650C2D3
    Related
    ENSP00000395849.2, ENST00000429845.6
    Conserved Domains (1) summary
    cd08528
    Location:518 → 785
    STKc_Nek10; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 10

  11. NM_001394971.1 → NP_001381900.1  serine/threonine-protein kinase Nek10 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC093555, AC098931, AC099535
    UniProtKB/TrEMBL
    A0A650C2C8, A0A650C2D3
    Conserved Domains (1) summary
    cd08528
    Location:518 → 785
    STKc_Nek10; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 10

  12. NM_152534.6 → NP_689747.3  serine/threonine-protein kinase Nek10 isoform 2

    See identical proteins and their annotated locations for NP_689747.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the inferred longest transcript and encodes the longest isoform (2).
    Source sequence(s)
    AC093555, AC098931, AC099535
    UniProtKB/Swiss-Prot
    A8MWG1, B9ZVR0, Q45VJ4, Q6ZR11, Q6ZWH5, Q7Z671, Q86XB1, Q96MB3
    UniProtKB/TrEMBL
    A0A650C2D3
    Conserved Domains (1) summary
    cd08528
    Location:518 → 785
    STKc_Nek10; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 10

  13. NM_199347.4 → NP_955379.2  serine/threonine-protein kinase Nek10 isoform 3

    See identical proteins and their annotated locations for NP_955379.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks multiple 3' coding exons and contains an alternate 3' terminal exon, compared to variant 2, resulting in a different 3' coding region and 3' UTR. The encoded isoform (3) has a distinct C-terminus and is shorter than isoform 2.
    Source sequence(s)
    AK098832, AK123061, BX537852
    Consensus CDS
    CCDS46781.1
    UniProtKB/Swiss-Prot
    Q6ZWH5
    UniProtKB/TrEMBL
    Q8N774
    Related
    ENSP00000343847.5, ENST00000341435.9
    Conserved Domains (2) summary
    smart00220
    Location:519 → 695
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:518 → 697
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    27106484..27369383 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047447506.1 → XP_047303462.1  serine/threonine-protein kinase Nek10 isoform X6

  2. XM_047447508.1 → XP_047303464.1  serine/threonine-protein kinase Nek10 isoform X8

  3. XM_017005763.2 → XP_016861252.1  serine/threonine-protein kinase Nek10 isoform X1

    UniProtKB/Swiss-Prot
    A8MWG1, B9ZVR0, Q45VJ4, Q6ZR11, Q6ZWH5, Q7Z671, Q86XB1, Q96MB3
    UniProtKB/TrEMBL
    A0A650C2D3
    Conserved Domains (1) summary
    cd08528
    Location:518 → 785
    STKc_Nek10; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 10

  4. XM_047447507.1 → XP_047303463.1  serine/threonine-protein kinase Nek10 isoform X7

  5. XM_017005768.2 → XP_016861257.1  serine/threonine-protein kinase Nek10 isoform X4

    UniProtKB/TrEMBL
    A0A650C2D3

  6. XM_006713001.4 → XP_006713064.1  serine/threonine-protein kinase Nek10 isoform X5

    UniProtKB/TrEMBL
    A0A650C2D3, A0A8I5KTB8
    Conserved Domains (1) summary
    cd08528
    Location:518 → 785
    STKc_Nek10; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 10

  7. XM_047447505.1 → XP_047303461.1  serine/threonine-protein kinase Nek10 isoform X5

    UniProtKB/TrEMBL
    A0A8I5KTB8

  8. XM_017005762.3 → XP_016861251.1  serine/threonine-protein kinase Nek10 isoform X1

    UniProtKB/Swiss-Prot
    A8MWG1, B9ZVR0, Q45VJ4, Q6ZR11, Q6ZWH5, Q7Z671, Q86XB1, Q96MB3
    UniProtKB/TrEMBL
    A0A650C2D3
    Conserved Domains (1) summary
    cd08528
    Location:518 → 785
    STKc_Nek10; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 10

  9. XM_017005764.2 → XP_016861253.1  serine/threonine-protein kinase Nek10 isoform X1

    UniProtKB/Swiss-Prot
    A8MWG1, B9ZVR0, Q45VJ4, Q6ZR11, Q6ZWH5, Q7Z671, Q86XB1, Q96MB3
    UniProtKB/TrEMBL
    A0A650C2D3
    Conserved Domains (1) summary
    cd08528
    Location:518 → 785
    STKc_Nek10; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 10

  10. XM_017005765.2 → XP_016861254.1  serine/threonine-protein kinase Nek10 isoform X1

    UniProtKB/Swiss-Prot
    A8MWG1, B9ZVR0, Q45VJ4, Q6ZR11, Q6ZWH5, Q7Z671, Q86XB1, Q96MB3
    UniProtKB/TrEMBL
    A0A650C2D3
    Conserved Domains (1) summary
    cd08528
    Location:518 → 785
    STKc_Nek10; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 10

  11. XM_006712999.4 → XP_006713062.1  serine/threonine-protein kinase Nek10 isoform X3

    UniProtKB/TrEMBL
    A0A650C2D3
    Conserved Domains (2) summary
    smart00220
    Location:519 → 779
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08528
    Location:518 → 785
    STKc_Nek10; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 10

  12. XM_006712998.3 → XP_006713061.1  serine/threonine-protein kinase Nek10 isoform X2

    UniProtKB/TrEMBL
    A0A650C2D3
    Conserved Domains (2) summary
    smart00220
    Location:519 → 779
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08528
    Location:518 → 785
    STKc_Nek10; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 10

  13. XM_047447509.1 → XP_047303465.1  serine/threonine-protein kinase Nek10 isoform X9

  14. XM_011533414.3 → XP_011531716.1  serine/threonine-protein kinase Nek10 isoform X12

    Conserved Domains (2) summary
    smart00220
    Location:519 → 669
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:518 → 672
    PKc_like; Protein Kinases, catalytic domain

  15. XM_047447512.1 → XP_047303468.1  serine/threonine-protein kinase Nek10 isoform X14

  16. XM_047447511.1 → XP_047303467.1  serine/threonine-protein kinase Nek10 isoform X13

  17. XM_047447510.1 → XP_047303466.1  serine/threonine-protein kinase Nek10 isoform X11

  18. XM_017005774.3 → XP_016861263.1  serine/threonine-protein kinase Nek10 isoform X10

    Conserved Domains (2) summary
    smart00220
    Location:519 → 669
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:518 → 672
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_001740034.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    27108644..27371532 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054345373.1 → XP_054201348.1  serine/threonine-protein kinase Nek10 isoform X6

  2. XM_054345375.1 → XP_054201350.1  serine/threonine-protein kinase Nek10 isoform X8

  3. XM_054345364.1 → XP_054201339.1  serine/threonine-protein kinase Nek10 isoform X1

    UniProtKB/Swiss-Prot
    A8MWG1, B9ZVR0, Q45VJ4, Q6ZR11, Q6ZWH5, Q7Z671, Q86XB1, Q96MB3

  4. XM_054345374.1 → XP_054201349.1  serine/threonine-protein kinase Nek10 isoform X7

  5. XM_054345370.1 → XP_054201345.1  serine/threonine-protein kinase Nek10 isoform X4

  6. XM_054345372.1 → XP_054201347.1  serine/threonine-protein kinase Nek10 isoform X5

    UniProtKB/TrEMBL
    A0A8I5KTB8

  7. XM_054345371.1 → XP_054201346.1  serine/threonine-protein kinase Nek10 isoform X5

    UniProtKB/TrEMBL
    A0A8I5KTB8

  8. XM_054345366.1 → XP_054201341.1  serine/threonine-protein kinase Nek10 isoform X1

    UniProtKB/Swiss-Prot
    A8MWG1, B9ZVR0, Q45VJ4, Q6ZR11, Q6ZWH5, Q7Z671, Q86XB1, Q96MB3

  9. XM_054345367.1 → XP_054201342.1  serine/threonine-protein kinase Nek10 isoform X1

    UniProtKB/Swiss-Prot
    A8MWG1, B9ZVR0, Q45VJ4, Q6ZR11, Q6ZWH5, Q7Z671, Q86XB1, Q96MB3

  10. XM_054345365.1 → XP_054201340.1  serine/threonine-protein kinase Nek10 isoform X1

    UniProtKB/Swiss-Prot
    A8MWG1, B9ZVR0, Q45VJ4, Q6ZR11, Q6ZWH5, Q7Z671, Q86XB1, Q96MB3

  11. XM_054345369.1 → XP_054201344.1  serine/threonine-protein kinase Nek10 isoform X3

  12. XM_054345368.1 → XP_054201343.1  serine/threonine-protein kinase Nek10 isoform X2

  13. XM_054345376.1 → XP_054201351.1  serine/threonine-protein kinase Nek10 isoform X9

  14. XM_054345379.1 → XP_054201354.1  serine/threonine-protein kinase Nek10 isoform X12

  15. XM_054345381.1 → XP_054201356.1  serine/threonine-protein kinase Nek10 isoform X14

  16. XM_054345380.1 → XP_054201355.1  serine/threonine-protein kinase Nek10 isoform X13

  17. XM_054345378.1 → XP_054201353.1  serine/threonine-protein kinase Nek10 isoform X11

  18. XM_054345377.1 → XP_054201352.1  serine/threonine-protein kinase Nek10 isoform X10

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZWH5.3 GenPept UniProtKB/Swiss-Prot:Q6ZWH5

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