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tax p40 [ Human T-cell leukemia virus type I ]

Gene ID: 1491938, updated on 18-Aug-2023

Summary

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Gene symbol
tax
Gene description
p40
Locus tag
HTLV1gp7
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Human T-cell leukemia virus type I
Lineage
Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes; Ortervirales; Retroviridae; Orthoretrovirinae; Deltaretrovirus
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Genomic context

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Sequence:
NC_001436.1 (4829..8008)

NC_001436.1Genomic Context describing neighboring genes Neighboring gene Pr gag-pro Neighboring gene Pr gag-pro-pol Neighboring gene Pr55 Neighboring gene Neighboring gene Neighboring gene p27 Neighboring gene protein-coding

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001436.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Tax is involved in up-regulation of HMGB1 expression levels by interaction with C/EBP. Zhang CG, et al. Asian Pac J Cancer Prev, 2013. PMID 23534754
  2. Suppression of HTLV-1 replication by Tax-mediated rerouting of the p13 viral protein to nuclear speckles. Andresen V, et al. Blood, 2011 Aug 11. PMID 21677314, Free PMC Article
  3. Move or die: the fate of the Tax oncoprotein of HTLV-1. Lodewick J, et al. Viruses, 2011 Jun. PMID 21994756, Free PMC Article
  4. Activation of LTRs from different human endogenous retrovirus (HERV) families by the HTLV-1 tax protein and T-cell activators. Toufaily C, et al. Viruses, 2011 Nov. PMID 22163338, Free PMC Article
  5. Tax-dependent displacement of nucleosomes during transcriptional activation of human T-cell leukemia virus type 1. Lemasson I, et al. J Biol Chem, 2006 May 12. PMID 16547351

See all (179) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Coevolution of HTLV-1-HBZ, Tax, and proviral load with host IRF-1 and CCNA-2 in HAM/TSP patients.
    Title: Coevolution of HTLV-1-HBZ, Tax, and proviral load with host IRF-1 and CCNA-2 in HAM/TSP patients.
  2. Interplay between innate immunity and the viral oncoproteins Tax and HBZ in the pathogenesis and therapeutic response of HTLV-1 associated adult T cell leukemia.
    Title: Interplay between innate immunity and the viral oncoproteins Tax and HBZ in the pathogenesis and therapeutic response of HTLV-1 associated adult T cell leukemia.
  3. Polymorphisms in HTLV-1 Tax-responsive elements in HTLV-1-associated myelopathy/tropical spastic paraparesis patients are associated with reduced proviral load but not with disease progression.
    Title: Polymorphisms in HTLV-1 Tax-responsive elements in HTLV-1-associated myelopathy/tropical spastic paraparesis patients are associated with reduced proviral load but not with disease progression.
  4. Evaluating mRNA expression of tax, B chain of PDGF and PDGF-beta receptors as well as HTLV-I proviral load in ATL patients and healthy carriers.
    Title: Evaluating mRNA expression of tax, B chain of PDGF and PDGF-β receptors as well as HTLV-I proviral load in ATL patients and healthy carriers.
  5. Tax Induces the Recruitment of NF-kappaB to Unintegrated HIV-1 DNA To Rescue Viral Gene Expression and Replication.
    Title: Tax Induces the Recruitment of NF-κB to Unintegrated HIV-1 DNA To Rescue Viral Gene Expression and Replication.
  6. A novel positive feedback-loop between the HTLV-1 oncoprotein Tax and NF-kappaB activity in T-cells.
    Title: A novel positive feedback-loop between the HTLV-1 oncoprotein Tax and NF-κB activity in T-cells.
  7. Adult T-cell leukemia-lymphoma as a viral disease: Subtypes based on viral aspects.
    Title: Adult T-cell leukemia-lymphoma as a viral disease: Subtypes based on viral aspects.
  8. Intragenic recruitment of NF-kappaB drives splicing modifications upon activation by the oncogene Tax of HTLV-1.
    Title: Intragenic recruitment of NF-κB drives splicing modifications upon activation by the oncogene Tax of HTLV-1.
  9. These findings suggest that both Tax and HBZ can alter the expression of EOS through undetermined mechanisms, and dysregulated expression of EOS in peripheral blood mononuclear leukocytes of HTLV-1 infected individuals may contribute to the pathological progression of HTLV-1-associated diseases.
    Title: EOS, an Ikaros family zinc finger transcription factor, interacts with the HTLV-1 oncoprotein Tax and is downregulated in peripheral blood mononuclear cells of HTLV-1-infected individuals, irrespective of clinical statuses.
  10. These findings allude to a mechanism whereby NF-kappaB-signaling regulates tubulin dynamics and mitotic instability through the modulation of p65(RelA)-Stathmin/Op-18 interactions, and support the notion that p30(II) enhances the survival of Tax-expressing HTLV-1-transformed cells.
    Title: The human T-cell leukemia virus type-1 tax oncoprotein dissociates NF-κB p65(RelA)-Stathmin complexes and causes catastrophic mitotic spindle damage and genomic instability.
Submit: New GeneRIF Correction See all GeneRIFs (171)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

General protein information

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Preferred Names
p40

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001436.1 Reference assembly

    Range
    4829..8008
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_057864.1 p40 [Human T-cell leukemia virus type I]

    See identical proteins and their annotated locations for NP_057864.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O56231, P14079
    UniProtKB/TrEMBL
    A0A1D8I0X7, A0A1Y1C906, A0A1Y1CA82
    Conserved Domains (1) summary
    pfam02959
    Location:3 → 224
    Tax; HTLV Tax
Nucleotide Protein
Heading Accession and Version

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