F fusion glycoprotein [Human orthopneumovirus] - Gene

Summary

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Gene symbol: F
Gene description: fusion glycoprotein
Locus tag: HRSVgp08
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Human orthopneumovirus (strain: B1)
Lineage: Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina; Monjiviricetes; Mononegavirales; Pneumoviridae; Orthopneumovirus
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Genomic context

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Sequence:: NC_001781.1 (5653..7552)

NC_001781.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:: NC_001781.1

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A Respiratory Syncytial Virus Attachment Gene Variant Associated with More Severe Disease in Infants Decreases Fusion Protein Expression, Which May Facilitate Immune Evasion.
Title: A Respiratory Syncytial Virus Attachment Gene Variant Associated with More Severe Disease in Infants Decreases Fusion Protein Expression, Which May Facilitate Immune Evasion.
used a rHPIV1 vector, bearing a stabilized attenuating mutation, to express the RSV F glycoprotein bearing amino acid substitutions that increase its stability in the pre-F form, the most immunogenic form that elicits highly functional virus-neutralizing antibodies
Title: Attenuated Human Parainfluenza Virus Type 1 Expressing the Respiratory Syncytial Virus (RSV) Fusion (F) Glycoprotein from an Added Gene: Effects of Prefusion Stabilization and Packaging of RSV F.
Data suggest that the profile of IgG3 specific to fusion protein (F protein) reflects infants' own antibody response after respiratory syncytial virus (RSV) infection.
Title: Age-Specific Profiles of Antibody Responses against Respiratory Syncytial Virus Infection.
Overall, human respiratory syncytial virus expressing the F of virus strain 2-20 had a high dependence on G for binding, entry, and infection.
Title: Respiratory Syncytial Virus Attachment Glycoprotein Contribution to Infection Depends on the Specific Fusion Protein.
Prefusion RSV F induced a larger quantity and higher quality of RSV-neutralizing serum antibodies and was highly protective
Title: Enhanced Neutralizing Antibody Response Induced by Respiratory Syncytial Virus Prefusion F Protein Expressed by a Vaccine Candidate.
Authors defined residues 79/191 as critical for human respiratory syncytial virus strain A2-line 19 F fusion activity and 357/371 as playing a role in mucus induction.
Title: Identification of residues in the human respiratory syncytial virus fusion protein that modulate fusion activity and pathogenesis.
R145 epitope is required for the post-fusion conformation change of F protein.
Title: Polyclonal and monoclonal antibodies specific for the six-helix bundle of the human respiratory syncytial virus fusion glycoprotein as probes of the protein post-fusion conformation.
A K66E mutation in the F2 fragment of the fusion (F) protein as the cause of the growth and CPE differences.
Title: A single amino acid in the F2 subunit of respiratory syncytial virus fusion protein alters growth and fusogenicity.
Data indicate that despite the conserved nature of the fusion protein (F protein), the variation does occur between different strains and between the subtypes.
Title: Molecular epidemiology and phylodynamics of the human respiratory syncytial virus fusion protein in northern Taiwan.
RAGE appeared to interact directly with the F protein, but, rather than inhibiting respiratory syncytial virus entry into host cells, virus replication and budding, membrane-expressed RAGE or soluble RAGE blocked F-protein-mediated syncytium formation and sloughing.
Title: RAGE inhibits human respiratory syncytial virus syncytium formation by interfering with F-protein function.

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General gene information

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Homology

Orthologs from OrthoDB

General protein information

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Preferred Names: fusion glycoprotein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

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Reference assembly

Genomic

NC_001781.1 Reference assembly

Range

5653..7552

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NP_056863.1 fusion glycoprotein [Human orthopneumovirus]

See identical proteins and their annotated locations for NP_056863.1

Status: PROVISIONAL

UniProtKB/Swiss-Prot

O36634

UniProtKB/TrEMBL

A0A1V0E289, A0A3Q9JNE2, O36636

Conserved Domains (1) summary

pfam00523
Location:29 → 520

Fusion_gly; Fusion glycoprotein F0