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F fusion protein [ Measles morbillivirus ]

Gene ID: 1489800, updated on 18-Aug-2023

Summary

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Gene symbol
F
Gene description
fusion protein
Locus tag
MeVgp4
Gene type
protein coding
RNA name
F gene
RefSeq status
PROVISIONAL
Organism
Measles morbillivirus (strain: Ichinose-B95a)
Lineage
Viruses; ssRNA viruses; ssRNA negative-strand viruses; Mononegavirales; Paramyxoviridae; Morbillivirus
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Genomic context

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Sequence:
NC_001498.1 (4876..7247)

NC_001498.1Genomic Context describing neighboring genes Neighboring gene C protein;V protein;phosphoprotein Neighboring gene matrix protein Neighboring gene hemagglutinin protein Neighboring gene large polymerase protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001498.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Measles Virus Bearing Measles Inclusion Body Encephalitis-Derived Fusion Protein Is Pathogenic after Infection via the Respiratory Route. Mathieu C, et al. J Virol, 2019 Apr 15. PMID 30728259, Free PMC Article
  2. Two domains that control prefusion stability and transport competence of the measles virus fusion protein. Doyle J, et al. J Virol, 2006 Feb. PMID 16415028, Free PMC Article
  3. Effect of the alterations in the fusion protein of measles virus isolated from brains of patients with subacute sclerosing panencephalitis on syncytium formation. Ayata M, et al. Virus Res, 2007 Dec. PMID 17825451
  4. High-density rafts preferentially host the complement activator measles virus F glycoprotein but not the regulators of complement activation. Ghannam A, et al. Mol Immunol, 2008 Jun. PMID 18455798
  5. The measles virus fusion protein transmembrane region modulates availability of an active glycoprotein complex and fusion efficiency. Mühlebach MD, et al. J Virol, 2008 Nov. PMID 18786999, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. M protein of subacute sclerosing panencephalitis virus, synergistically with the F protein, plays a crucial role in viral neuropathogenicity.
    Title: M protein of subacute sclerosing panencephalitis virus, synergistically with the F protein, plays a crucial role in viral neuropathogenicity.
  2. Measles Virus Bearing Measles Inclusion Body Encephalitis-Derived Fusion Protein Is Pathogenic after Infection via the Respiratory Route.
    Title: Measles Virus Bearing Measles Inclusion Body Encephalitis-Derived Fusion Protein Is Pathogenic after Infection via the Respiratory Route.
  3. Cell-to-Cell Measles Virus Spread between Human Neurons Is Dependent on Hemagglutinin and Hyperfusogenic Fusion Protein.
    Title: Cell-to-Cell Measles Virus Spread between Human Neurons Is Dependent on Hemagglutinin and Hyperfusogenic Fusion Protein.
  4. L454W F mutant is activated independently of H or the cell receptor that enabled the efficient spread in the central nervous system.
    Title: Measles fusion machinery is dysregulated in neuropathogenic variants.
  5. Acquisition of enhanced fusion activity through substitutions in the extracellular domain of the F protein may be crucial for measles virus to the extensive spread in the central nervous system and development of subacute sclerosing panencephalitis.
    Title: Measles virus mutants possessing the fusion protein with enhanced fusion activity spread effectively in neuronal cells, but not in other cells, without causing strong cytopathology.
  6. Complementation of F mutants with a monomeric, fusion-inactive F variant enriched the F oligomers for heterotrimers containing a single disulfide bond, without affecting fusion complementation profiles compared with standard F protein.
    Title: Efficient replication of a paramyxovirus independent of full zippering of the fusion protein six-helix bundle domain.
  7. F maturation prepares for complex separation after triggering, and the H head domains in prereceptor-bound conformation prevent premature stalk rearrangements and F activation.
    Title: Measles virus glycoprotein complexes preassemble intracellularly and relax during transport to the cell surface in preparation for fusion.
  8. Thermodynamically stabilized by the N465H substitution, the F protein required elevated temperature as high as 40 degrees C to promote cell-cell fusion, whereas all five DIII mutations caused destabilization of the F protein
    Title: Intramolecular complementation of measles virus fusion protein stability confers cell-cell fusion activity at 37 °C.
  9. Authors demonstrate that the measles virus H stalk represents the effector domain for measles virus F triggering.
    Title: A stabilized headless measles virus attachment protein stalk efficiently triggers membrane fusion.
  10. Taken together, these findings reveal that the morbillivirus H protein must lower the activation energy barrier of metastable prefusion F for fusion triggering.
    Title: Mechanism for active membrane fusion triggering by morbillivirus attachment protein.
Submit: New GeneRIF Correction See all GeneRIFs (20)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

General protein information

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Preferred Names
fusion protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001498.1 Reference assembly

    Range
    4876..7247
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_056922.1 fusion protein [Measles morbillivirus]

    See identical proteins and their annotated locations for NP_056922.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P08300, P69353, P69354, P69355, P69356, P69357, P69358, Q786F3
    UniProtKB/TrEMBL
    A0A0M3TG90, A0A2L0V7J2, A0A7D0P9U8, G5DD37, G5DD45, P90331, Q68KG1, Q784S2, Q9QEX0, Q9QEX1, Q9WMK4
    Conserved Domains (1) summary
    pfam00523
    Location:26 → 496
    Fusion_gly; Fusion glycoprotein F0
Nucleotide Protein
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