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POLY polyprotein [ Japanese encephalitis virus ]

Gene ID: 1489713, updated on 10-Oct-2024

Summary

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Gene symbol
POLY
Gene description
polyprotein
Locus tag
JEVgp1
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Japanese encephalitis virus
Lineage
Viruses; Riboviria; Flaviviridae; Flavivirus
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Genomic context

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Sequence:
NC_001437.1 (96..10394)

NC_001437.1Genomic Context describing neighboring genes Neighboring gene truncated JEV polyprotein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001437.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Adaptation of a live-attenuated genotype I Japanese encephalitis virus to vero cells is associated with mutations in structural protein genes. Anwar MN, et al. Virus Res, 2021 Jan 15. PMID 33285172
  2. Identification of a protective epitope in Japanese encephalitis virus NS1 protein. Zhou D, et al. Antiviral Res, 2020 Oct. PMID 32898585
  3. Mosquito Defensins Enhance Japanese Encephalitis Virus Infection by Facilitating Virus Adsorption and Entry within the Mosquito. Liu K, et al. J Virol, 2020 Oct 14. PMID 32796073, Free PMC Article
  4. Amino Acid at Position 166 of NS2A in Japanese Encephalitis Virus (JEV) is Associated with In Vitro Growth Characteristics of JEV. Tajima S, et al. Viruses, 2020 Jun 30. PMID 32629892, Free PMC Article
  5. Functional Correlation between Subcellular Localizations of Japanese Encephalitis Virus Capsid Protein and Virus Production. Ishida K, et al. J Virol, 2019 Oct 1. PMID 31315991, Free PMC Article

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Nucleotide at position 66 of NS2A in Japanese encephalitis virus is associated with the virulence and proliferation of virus.
    Title: Nucleotide at position 66 of NS2A in Japanese encephalitis virus is associated with the virulence and proliferation of virus.
  2. Japanese encephalitis virus NS1 and NS1' proteins induce vimentin rearrangement via the CDK1-PLK1 axis to promote viral replication.
    Title: Japanese encephalitis virus NS1 and NS1' proteins induce vimentin rearrangement via the CDK1-PLK1 axis to promote viral replication.
  3. Japanese encephalitis virus NS1 and NS1' protein disrupts the blood-brain barrier through macrophage migration inhibitory factor-mediated autophagy.
    Title: Japanese encephalitis virus NS1 and NS1' protein disrupts the blood-brain barrier through macrophage migration inhibitory factor-mediated autophagy.
  4. Japanese encephalitis virus inhibits superinfection of Zika virus in cells by the NS2B protein.
    Title: Japanese encephalitis virus inhibits superinfection of Zika virus in cells by the NS2B protein.
  5. Adaptation of a live-attenuated genotype I Japanese encephalitis virus to vero cells is associated with mutations in structural protein genes.
    Title: Adaptation of a live-attenuated genotype I Japanese encephalitis virus to vero cells is associated with mutations in structural protein genes.
  6. Identification of a protective epitope in Japanese encephalitis virus NS1 protein.
    Title: Identification of a protective epitope in Japanese encephalitis virus NS1 protein.
  7. Amino Acid at Position 166 of NS2A in Japanese Encephalitis Virus (JEV) is Associated with In Vitro Growth Characteristics of JEV.
    Title: Amino Acid at Position 166 of NS2A in Japanese Encephalitis Virus (JEV) is Associated with In Vitro Growth Characteristics of JEV.
  8. Mosquito Defensins Enhance Japanese Encephalitis Virus Infection by Facilitating Virus Adsorption and Entry within the Mosquito.
    Title: Mosquito Defensins Enhance Japanese Encephalitis Virus Infection by Facilitating Virus Adsorption and Entry within the Mosquito.
  9. Degradation of MicroRNA miR-466d-3p by Japanese Encephalitis Virus NS3 Facilitates Viral Replication and Interleukin-1beta Expression.
    Title: Degradation of MicroRNA miR-466d-3p by Japanese Encephalitis Virus NS3 Facilitates Viral Replication and Interleukin-1β Expression.
  10. A conformation-based intra-molecular initiation factor identified in the flavivirus RNA-dependent RNA polymerase.
    Title: A conformation-based intra-molecular initiation factor identified in the flavivirus RNA-dependent RNA polymerase.
Submit: New GeneRIF Correction See all GeneRIFs (54)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General protein information

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Preferred Names
polyprotein
Names
core protein C
anchored core protein anchC
membrane glycoprotein precursor prM
membrane glycoprotein M
envelope protein E
non-structural protein NS1
non-structural protein NS2a
non-structural protein NS2b
non-structural protein NS3
non-structural protein NS4a
2K protein
non-structural protein NS4b
RNA-dependent RNA polymerase NS5
protein pr

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001437.1 Reference assembly

    Range
    96..10394
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_059434.1 flavivirus polyprotein [Japanese encephalitis virus]

    See identical proteins and their annotated locations for NP_059434.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P32886
    UniProtKB/TrEMBL
    A0A088MEZ6
    Conserved Domains (16) summary
    cd12149
    Location:601 → 692
    Flavi_E_C; Immunoglobulin-like domain III (C-terminal domain) of Flavivirus envelope glycoprotein E
    TIGR04240
    Location:698 → 794
    flavi_E_stem; flavivirus envelope glycoprotein E, stem/anchor domain
    pfam00948
    Location:796 → 1149
    Flavi_NS1; Flavivirus non-structural Protein NS1
    pfam01002
    Location:1379 → 1504
    Flavi_NS2B; Flavivirus non-structural protein NS2B
    pfam01005
    Location:1158 → 1339
    Flavi_NS2A; Flavivirus non-structural protein NS2A
    pfam01349
    Location:2273 → 2518
    Flavi_NS4B; Flavivirus non-structural protein NS4B
    pfam01350
    Location:2129 → 2270
    Flavi_NS4A; Flavivirus non-structural protein NS4A
    pfam00949
    Location:1522 → 1671
    Peptidase_S7; Peptidase S7, Flavivirus NS3 serine protease
    cd17038
    Location:220 → 294
    Flavi_M; Flavivirus envelope glycoprotein M
    cd18806
    Location:1837 → 1981
    SF2_C_viral; C-terminal helicase domain of viral helicase
    pfam00869
    Location:297 → 592
    Flavi_glycoprot; Flavivirus glycoprotein, central and dimerization domains
    pfam00972
    Location:2780 → 3421
    Flavi_NS5; Flavivirus RNA-directed RNA polymerase
    pfam01003
    Location:6 → 123
    Flavi_capsid; Flavivirus capsid protein C
    pfam01570
    Location:155 → 211
    Flavi_propep; Flavivirus polyprotein propeptide
    pfam07652
    Location:1688 → 1835
    Flavi_DEAD; Flavivirus DEAD domain
    pfam01728
    Location:2582 → 2751
    FtsJ; FtsJ-like methyltransferase

  2. NP_775662.1 core protein C

    Conserved Domains (1) summary
    pfam01003
    Location:6 → 105
    Flavi_capsid; Flavivirus capsid protein C

  3. NP_775663.1 anchored core protein anchC

    UniProtKB/TrEMBL
    A0A7D5BXM1
    Conserved Domains (1) summary
    pfam01003
    Location:6 → 123
    Flavi_capsid; Flavivirus capsid protein C

  4. NP_775664.1 membrane glycoprotein precursor prM

    UniProtKB/TrEMBL
    I7DBK1, I7DLF2, Q91KX0
    Conserved Domains (2) summary
    pfam01004
    Location:94 → 167
    Flavi_M; Flavivirus envelope glycoprotein M
    pfam01570
    Location:7 → 91
    Flavi_propep; Flavivirus polyprotein propeptide

  5. NP_775665.1 membrane glycoprotein M

    Conserved Domains (1) summary
    pfam01004
    Location:2 → 75
    Flavi_M; Flavivirus envelope glycoprotein M

  6. NP_775666.1 envelope protein E

    UniProtKB/TrEMBL
    A0A0A7DW64, A0A2Z5VGC0, A0A2Z5VGC9, A0A2Z5VGD2, A0A2Z5VGD4, A0A2Z5VGE0, A0A2Z5VGE3, A0A2Z5VGE6, A0A2Z5VGF0, A0A2Z5VGF8, A0A2Z5VGG4, A0A2Z5VGH2, A0A2Z5VGJ1, A0A2Z5VGJ2, A0A2Z5VGL7, A0A2Z5VGN4, A0A2Z5VGN8, A0A2Z5VGQ5, A0A2Z5VH48, A0A510EAX9, A2SW19, C7T459, C8CKT9, D6MM36, D6MM58, E1U800, E1U815, Q67A00, Q76TE0
    Conserved Domains (3) summary
    cd12149
    Location:307 → 398
    Flavi_E_C; Immunoglobulin-like domain III (C-terminal domain) of Flavivirus envelope glycoprotein E
    TIGR04240
    Location:404 → 500
    flavi_E_stem; flavivirus envelope glycoprotein E, stem/anchor domain
    pfam00869
    Location:3 → 298
    Flavi_glycoprot; Flavivirus glycoprotein, central and dimerisation domains

  7. NP_775667.1 non-structural protein NS1

    UniProtKB/TrEMBL
    Q77TS4, Q9YJ16
    Conserved Domains (1) summary
    pfam00948
    Location:2 → 352
    Flavi_NS1; Flavivirus non-structural Protein NS1

  8. NP_775668.1 non-structural protein NS2a

    Conserved Domains (1) summary
    pfam01005
    Location:12 → 193
    Flavi_NS2A; Flavivirus non-structural protein NS2A

  9. NP_775669.1 non-structural protein NS2b

    UniProtKB/TrEMBL
    A0A7D4Y062
    Conserved Domains (1) summary
    pfam01002
    Location:6 → 131
    Flavi_NS2B; Flavivirus non-structural protein NS2B

  10. NP_775670.1 non-structural protein NS3

    UniProtKB/TrEMBL
    F6KGY1
    Conserved Domains (4) summary
    smart00487
    Location:181 → 326
    DEXDc; DEAD-like helicases superfamily
    pfam00949
    Location:19 → 167
    Peptidase_S7; Peptidase S7, Flavivirus NS3 serine protease
    pfam07652
    Location:186 → 331
    Flavi_DEAD; Flavivirus DEAD domain
    cl21455
    Location:357 → 465
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  11. NP_775671.1 non-structural protein NS4a

    Conserved Domains (1) summary
    pfam01350
    Location:6 → 126
    Flavi_NS4A; Flavivirus non-structural protein NS4A

  12. NP_775672.1 2K protein

  13. NP_775673.1 non-structural protein NS4b

    Conserved Domains (1) summary
    pfam01349
    Location:1 → 246
    Flavi_NS4B; Flavivirus non-structural protein NS4B

  14. NP_775674.1 RNA-dependent RNA polymerase NS5

    Conserved Domains (2) summary
    pfam00972
    Location:255 → 894
    Flavi_NS5; Flavivirus RNA-directed RNA polymerase
    pfam01728
    Location:55 → 223
    FtsJ; FtsJ-like methyltransferase

  15. YP_009333132.1 protein pr

Nucleotide Protein
Heading Accession and Version

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