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ORF68 envelope glycoprotein E [ Human alphaherpesvirus 3 (Varicella-zoster virus) ]

Gene ID: 1487709, updated on 18-Aug-2023

Summary

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Gene symbol
ORF68
Gene description
envelope glycoprotein E
Locus tag
HHV3_gp69
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Human alphaherpesvirus 3 (strain: Dumas, acronym: HHV-3, acronym: VZV, nat-host: Homo sapiens)
Lineage
Viruses; dsDNA viruses, no RNA stage; Herpesvirales; Herpesviridae; Alphaherpesvirinae; Varicellovirus
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Genomic context

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Sequence:
NC_001348.1 (115808..117721)

NC_001348.1Genomic Context describing neighboring genes Neighboring gene serine/threonine protein kinase US3 Neighboring gene envelope glycoprotein I Neighboring gene virion protein US10 Neighboring gene regulatory protein ICP22

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001348.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Autophagy and the effects of its inhibition on varicella-zoster virus glycoprotein biosynthesis and infectivity. Buckingham EM, et al. J Virol, 2014 Jan. PMID 24198400, Free PMC Article
  2. [Sequence analysis of varicella-zoster virus gE gene in varicella-zoster virus strains with different clades]. Jiang LF, et al. Bing Du Xue Bao, 2013 Mar. PMID 23757839
  3. Varicella-zoster virus glycoprotein E is a critical determinant of virulence in the SCID mouse-human model of neuropathogenesis. Zerboni L, et al. J Virol, 2011 Jan. PMID 20962081, Free PMC Article
  4. The insulin degrading enzyme binding domain of varicella-zoster virus (VZV) glycoprotein E is important for cell-to-cell spread and VZV infectivity, while a glycoprotein I binding domain is essential for infection. Ali MA, et al. Virology, 2009 Apr 10. PMID 19233447, Free PMC Article
  5. Functions of the C-terminal domain of varicella-zoster virus glycoprotein E in viral replication in vitro and skin and T-cell tropism in vivo. Moffat J, et al. J Virol, 2004 Nov. PMID 15507627, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Expression and glycan processing of VZV gE were decreased after ATG5 knockdown.
    Title: Autophagy and the effects of its inhibition on varicella-zoster virus glycoprotein biosynthesis and infectivity.
  2. gE gene sequences revealed a novel non-synonymous mutations in the e1 and c1 epitopes.
    Title: [Sequence analysis of varicella-zoster virus gE gene in varicella-zoster virus strains with different clades].
  3. Substitution of four cysteine residues highly conserved in the Alphaherpesvirinae established that C95 is required for gE/gI heterodimer formation.
    Title: Mutagenesis of varicella-zoster virus glycoprotein I (gI) identifies a cysteine residue critical for gE/gI heterodimer formation, gI structure, and virulence in skin cells.
  4. GE/gI interaction is critical for VZV neurovirulence.
    Title: Varicella-zoster virus glycoprotein E is a critical determinant of virulence in the SCID mouse-human model of neuropathogenesis.
  5. data show that the nonconserved N-terminal region of varicella-zoster virus glycoprotein E is required for VZV tropism for T cells and skin, which is necessary for its life cycle in the human host
    Title: Functions of the unique N-terminal region of glycoprotein E in the pathogenesis of varicella-zoster virus infection.
  6. The precursor nonglycosylated gE form (73 kDa) found in the endoplasmic reticulum binds to Insulin-degrading enzyme.
    Title: Insulin-degrading enzyme binds to the nonglycosylated precursor of varicella-zoster virus gE protein found in the endoplasmic reticulum.
  7. HSV deleted for glycoprotein E is impaired for cell-to-cell spread, and VZV gE could not complement this activity.
    Title: The insulin degrading enzyme binding domain of varicella-zoster virus (VZV) glycoprotein E is important for cell-to-cell spread and VZV infectivity, while a glycoprotein I binding domain is essential for infection.
  8. Blocking gE binding to gI resulted in severe impairment of VZV infection of human skin xenografts in SCIDhu mice in vivo, documenting the importance of cell fusion mediated by this complex for VZV virulence in skin.
    Title: Deletion of the first cysteine-rich region of the varicella-zoster virus glycoprotein E ectodomain abolishes the gE and gI interaction and differentially affects cell-cell spread and viral entry.
  9. Incorporation of three endocytosed varicella-zoster virus glycoproteins, gE, gH, and gB, into the virion envelope.
    Title: Incorporation of three endocytosed varicella-zoster virus glycoproteins, gE, gH, and gB, into the virion envelope.
  10. C-terminal domain of varicella-zoster virus glycoprotein E plays a role in viral replication in vitro and skin and T-cell tropism in vivo.
    Title: Functions of the C-terminal domain of varicella-zoster virus glycoprotein E in viral replication in vitro and skin and T-cell tropism in vivo.
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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

regulatory

  • Loc: 117716-117721 regulatory_class = polyA_signal_sequence

General protein information

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Preferred Names
envelope glycoprotein E
NP_040190.1
  • gE family

VOG classification

Description:

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001348.1 Reference assembly

    Range
    115808..117721
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_040190.1 envelope glycoprotein E [Human alphaherpesvirus 3]

    See identical proteins and their annotated locations for NP_040190.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P09259, Q9J3M8
    UniProtKB/TrEMBL
    A0A0F7GJ36, Q0Q9P6, Q6QCI8, Q76ZB7, Q77JF5, Q77JX0, Q9DK01
    Conserved Domains (1) summary
    PHA03281
    Location:1 → 621
    PHA03281; envelope glycoprotein E; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
CAA27951.1

Gene LinkOut

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