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E1A control protein E1A [ Human mastadenovirus A ]

Gene ID: 1460853, updated on 18-Aug-2023

Summary

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Gene symbol
E1A
Gene description
control protein E1A
Locus tag
HAdVAgp01
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Human mastadenovirus A (strain: Huie, serotype: Human adenovirus 12, acronym: HAdV-12, acronym: HAdV-A, nat-host: Homo sapiens, culture-collection: ATCC:VR-863)
Lineage
Viruses; Varidnaviria; Bamfordvirae; Preplasmiviricota; Tectiliviricetes; Rowavirales; Adenoviridae; Mastadenovirus
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Genomic context

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Sequence:
NC_001460.1 (415..1442)

NC_001460.1Genomic Context describing neighboring genes Neighboring gene control protein E1B 19K;control protein E1B 55K Neighboring gene encapsidation protein IVa2 Neighboring gene capsid protein IX Neighboring gene DNA polymerase;terminal protein precursor pTP

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001460.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Adenoviral E1A Exploits Flexibility and Disorder to Target Cellular Proteins. Murrali MG, et al. Biomolecules, 2020 Nov 11. PMID 33187345, Free PMC Article
  2. Efficient Transformation of Primary Human Mesenchymal Stromal Cells by Adenovirus Early Region 1 Oncogenes. Speiseder T, et al. J Virol, 2017 Jan 1. PMID 27795433, Free PMC Article
  3. The adenoviral E1A oncoprotein activates the Smad7 promoter: requirement of a functional E-box. Dole VS, et al. Int J Oncol, 2009 Dec. PMID 19885573
  4. E1A inhibits transforming growth factor-beta signaling through binding to Smad proteins. Nishihara A, et al. J Biol Chem, 1999 Oct 1. PMID 10497242
  5. Cytoplasmic displacement of cyclin E-cdk2 inhibitors p21Cip1 and p27Kip1 in anchorage-independent cells. Orend G, et al. Oncogene, 1998 May. PMID 9632134

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Adenoviral E1A Exploits Flexibility and Disorder to Target Cellular Proteins.
    Title: Adenoviral E1A Exploits Flexibility and Disorder to Target Cellular Proteins.
  2. Human adenovirus E1A and E1B early oncogene proteins expressed in primary progenitor cells transform them to exhibit features of tumor cells.
    Title: Efficient Transformation of Primary Human Mesenchymal Stromal Cells by Adenovirus Early Region 1 Oncogenes.
  3. Adenovirus E1A oncoprotein is sufficient to induce Smad7 expression, an inhibitor of TGF-beta signalling.
    Title: The adenoviral E1A oncoprotein activates the Smad7 promoter: requirement of a functional E-box.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

regulatory

  • Loc: 1398-1403 regulatory_class = polyA_signal_sequence
  • Loc: 1437-1442 regulatory_class = polyA_signal_sequence
  • Loc: 415-420 regulatory_class = TATA_box

General protein information

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Preferred Names
control protein E1A
NP_040910.2
  • genus-specific

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001460.1 Reference assembly

    Range
    415..1442
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_040910.2 control protein E1A [Human mastadenovirus A]

    See identical proteins and their annotated locations for NP_040910.2

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P03259
    UniProtKB/TrEMBL
    A0A3G1HCH6
    Conserved Domains (1) summary
    pfam02703
    Location:9 → 264
    Adeno_E1A; Early E1A protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
CAA51877.1

Gene LinkOut

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