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CSNK1G3 casein kinase 1 gamma 3 [ Homo sapiens (human) ]

Gene ID: 1456, updated on 14-Nov-2024

Summary

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Official Symbol
CSNK1G3provided by HGNC
Official Full Name
casein kinase 1 gamma 3provided by HGNC
Primary source
HGNC:HGNC:2456
See related
Ensembl:ENSG00000151292 MIM:604253; AllianceGenome:HGNC:2456
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CSNK1G3L; CKI-gamma 3
Summary
This gene encodes a member of a family of serine/threonine protein kinases that phosphorylate caseins and other acidic proteins. A related protein in the African clawed frog participates in the transmission of Wnt/beta-catenin signaling. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Expression
Ubiquitous expression in colon (RPKM 8.2), small intestine (RPKM 7.3) and 25 other tissues See more
Orthologs
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Genomic context

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See CSNK1G3 in Genome Data Viewer
Location:
5q23.2
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (123512177..123617049)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (124028409..124133283)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (122847871..122952743)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:122758363-122759308 Neighboring gene centrosomal protein 120 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16274 Neighboring gene keratin 8 pseudogene 33 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23003 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23004 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16275 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16276 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23005 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:122861667-122861854 Neighboring gene high mobility group box 3 pseudogene 17 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23006 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:122964549-122965050 Neighboring gene keratin 18 pseudogene 16 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:123210028-123210778 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:123210779-123211528 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:123211529-123212279 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:123360854-123361427 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23007 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23008 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:123423241-123423991 Neighboring gene long intergenic non-protein coding RNA 1170 Neighboring gene uncharacterized LOC101927397

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Intratumoral heterogeneity of CSNK1G3 mutations, a casein kinase 1, in colon cancers. Son HJ, et al. Pathol Res Pract, 2020 May. PMID 32241596
  2. A novel consensus phosphorylation motif in sulfatide- and cholesterol-3-sulfate-binding protein substrates for CK1 in vitro. Kawakami F, et al. Biol Pharm Bull, 2008 Feb. PMID 18239272
  3. Cloning and chromosome mapping of the human casein kinase I gamma3 gene (CSNK1G3). Kusuda J, et al. Cytogenet Cell Genet, 1998. PMID 9925945
  4. Protein proximity networks and functional evaluation of the casein kinase 1 gamma family reveal unique roles for CK1γ3 in WNT signaling. Agajanian MJ, et al. J Biol Chem, 2022 Jun. PMID 35487243, Free PMC Article
  5. The casein kinase I family in Wnt signaling. McKay RM, et al. Dev Biol, 2001 Jul 15. PMID 11437445

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A novel nanoplatform-based circCSNK1G3 affects CBX7 protein and promotes glioma cell growth.
    Title: A novel nanoplatform-based circCSNK1G3 affects CBX7 protein and promotes glioma cell growth.
  2. circCsnk1g3- and circAnkib1-regulated interferon responses in sarcoma promote tumorigenesis by shaping the immune microenvironment.
    Title: circCsnk1g3- and circAnkib1-regulated interferon responses in sarcoma promote tumorigenesis by shaping the immune microenvironment.
  3. Protein proximity networks and functional evaluation of the casein kinase 1 gamma family reveal unique roles for CK1gamma3 in WNT signaling.
    Title: Protein proximity networks and functional evaluation of the casein kinase 1 gamma family reveal unique roles for CK1γ3 in WNT signaling.
  4. Intratumoral heterogeneity of CSNK1G3 mutations, a casein kinase 1, in colon cancers.
    Title: Intratumoral heterogeneity of CSNK1G3 mutations, a casein kinase 1, in colon cancers.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Discovery and refinement of loci associated with lipid levels.
EBI GWAS Catalog
Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis.
EBI GWAS Catalog

Variation

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See Variation Viewer (GRCh37.p13)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Vpu vpu In vitro protein-protein interaction analysis identifies a Vpu-binding host protein casein kinase 1, gamma 3 (CSNK1G3) PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 3-phosphoinositide-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables AMP-activated protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables Rho-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables eukaryotic translation initiation factor 2alpha kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS121 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AT120 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AXS139 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2BS14 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2BS36 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S10 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S28 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S57 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T11 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T3 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T45 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T6 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H4S1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity TAS
Traceable Author Statement
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ribosomal protein S6 kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein modification process TAS
Traceable Author Statement
more info
 PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
casein kinase I isoform gamma-3; casein kinase I
NP_001026982.1
NP_001038188.1
NP_001257501.1
NP_001257502.1
NP_001257503.1
NP_001351069.1
NP_001351070.1
NP_001351072.1
NP_001351073.1
NP_001351074.1
NP_001351075.1
NP_001351076.1
NP_001351077.1
NP_001351078.1
NP_001351079.1
NP_004375.2
XP_005271949.1
XP_005271952.1
XP_016864546.1
XP_016864548.1
XP_016864549.1
XP_016864551.1
XP_016864552.1
XP_016864553.1
XP_016864554.1
XP_016864556.1
XP_016864557.1
XP_016864558.1
XP_016864559.1
XP_047272698.1
XP_047272699.1
XP_047272700.1
XP_047272701.1
XP_047272702.1
XP_047272703.1
XP_047272704.1
XP_047272705.1
XP_047272706.1
XP_047272707.1
XP_047272708.1
XP_047272710.1
XP_047272711.1
XP_047272712.1
XP_047272713.1
XP_047272714.1
XP_047272715.1
XP_047272716.1
XP_047272717.1
XP_047272719.1
XP_047272720.1
XP_047272721.1
XP_047272722.1
XP_047272723.1
XP_047272724.1
XP_047272725.1
XP_047272726.1
XP_047272727.1
XP_047272728.1
XP_047272729.1
XP_047272730.1
XP_047272731.1
XP_054207639.1
XP_054207640.1
XP_054207641.1
XP_054207642.1
XP_054207643.1
XP_054207644.1
XP_054207645.1
XP_054207646.1
XP_054207647.1
XP_054207648.1
XP_054207649.1
XP_054207650.1
XP_054207651.1
XP_054207652.1
XP_054207653.1
XP_054207654.1
XP_054207655.1
XP_054207656.1
XP_054207657.1
XP_054207658.1
XP_054207659.1
XP_054207660.1
XP_054207661.1
XP_054207662.1
XP_054207663.1
XP_054207664.1
XP_054207665.1
XP_054207666.1
XP_054207667.1
XP_054207668.1
XP_054207669.1
XP_054207670.1
XP_054207671.1
XP_054207672.1
XP_054207673.1
XP_054207674.1
XP_054207675.1
XP_054207676.1
XP_054207677.1
XP_054207678.1
XP_054207679.1
XP_054207680.1
XP_054207681.1
XP_054207682.1
XP_054207683.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031812.4 → NP_001026982.1  casein kinase I isoform gamma-3 isoform 2

    See identical proteins and their annotated locations for NP_001026982.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and has multiple differences in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC008541, AF049089, BC047567, BX116822, DA409424
    Consensus CDS
    CCDS34218.1
    UniProtKB/Swiss-Prot
    Q9Y6M4
    Related
    ENSP00000429412.1, ENST00000521364.5
    Conserved Domains (2) summary
    cd14126
    Location:42 → 328
    STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
    pfam12605
    Location:328 → 385
    CK1gamma_C; Casein kinase 1 gamma C terminal

  2. NM_001044723.2 → NP_001038188.1  casein kinase I isoform gamma-3 isoform 4

    See identical proteins and their annotated locations for NP_001038188.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4, also known as CSNK1G3L) contains an alternate exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (4) is longer than isoform 1.
    Source sequence(s)
    AC008541, AF049090, BC047567, BX116822
    Consensus CDS
    CCDS43355.1
    UniProtKB/Swiss-Prot
    Q9Y6M4
    Related
    ENSP00000353904.2, ENST00000360683.6
    Conserved Domains (2) summary
    cd14126
    Location:42 → 328
    STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
    pfam12605
    Location:328 → 417
    CK1gamma_C; Casein kinase 1 gamma C terminal

  3. NM_001270572.1 → NP_001257501.1  casein kinase I isoform gamma-3 isoform 5

    See identical proteins and their annotated locations for NP_001257501.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) has multiple differences in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (5) is shorter than isoform 1.
    Source sequence(s)
    AC008541, AK289405, BC047567, BX116822
    Consensus CDS
    CCDS59491.1
    UniProtKB/Swiss-Prot
    Q9Y6M4
    Related
    ENSP00000423838.2, ENST00000510842.6
    Conserved Domains (2) summary
    cd14126
    Location:42 → 329
    STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
    pfam12605
    Location:329 → 386
    CK1gamma_C; Casein kinase 1 gamma C terminal

  4. NM_001270573.2 → NP_001257502.1  casein kinase I isoform gamma-3 isoform 6

    See identical proteins and their annotated locations for NP_001257502.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and has multiple differences in the coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (6) has a shorter N-terminus, compared to isoform 1. Variants 6, 16, and 17 all encode the same isoform (6).
    Source sequence(s)
    AC008541, AK299739, BX116822, DA409424
    Consensus CDS
    CCDS59492.1
    UniProtKB/Swiss-Prot
    Q9Y6M4
    Related
    ENSP00000421998.3, ENST00000512718.7
    Conserved Domains (2) summary
    pfam12605
    Location:253 → 310
    CK1gamma_C; Casein kinase 1 gamma C terminal
    cl21453
    Location:1 → 253
    PKc_like; Protein Kinases, catalytic domain

  5. NM_001270574.2 → NP_001257503.1  casein kinase I isoform gamma-3 isoform 7

    See identical proteins and their annotated locations for NP_001257503.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and has multiple differences in the coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (7) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC008541, AK316019, BX116822, DA409424
    Consensus CDS
    CCDS59493.1
    UniProtKB/Swiss-Prot
    Q9Y6M4
    Related
    ENSP00000421385.2, ENST00000511130.6
    Conserved Domains (2) summary
    pfam12605
    Location:216 → 273
    CK1gamma_C; Casein kinase 1 gamma C terminal
    cl21453
    Location:1 → 216
    PKc_like; Protein Kinases, catalytic domain

  6. NM_001364140.2 → NP_001351069.1  casein kinase I isoform gamma-3 isoform 8

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (8) is 1 aa longer compared to isoform 1 and is the longest isoform.
    Source sequence(s)
    AC008541, AC026422
    Consensus CDS
    CCDS93772.1
    UniProtKB/TrEMBL
    A0A8V8TKT3
    Related
    ENSP00000512966.1, ENST00000696905.1
    Conserved Domains (2) summary
    cd14126
    Location:42 → 329
    STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
    pfam12605
    Location:329 → 418
    CK1gamma_C; Casein kinase 1 gamma C terminal

  7. NM_001364141.2 → NP_001351070.1  casein kinase I isoform gamma-3 isoform 9

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) contains an alternate in-frame exon and lacks another alternate in-frame exon compared to variant 1. The resulting isoform (9) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC008541, AC026422
    Conserved Domains (2) summary
    cd14126
    Location:42 → 353
    STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
    pfam12605
    Location:353 → 399
    CK1gamma_C; Casein kinase 1 gamma C terminal

  8. NM_001364143.2 → NP_001351072.1  casein kinase I isoform gamma-3 isoform 10

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) uses an alternate in-frame splice junction and lacks two alternate in-frame exons compared to variant 1. The resulting isoform (10) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC008541, AC026422
    Conserved Domains (2) summary
    cd14126
    Location:42 → 329
    STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
    pfam12605
    Location:329 → 386
    CK1gamma_C; Casein kinase 1 gamma C terminal

  9. NM_001364144.2 → NP_001351073.1  casein kinase I isoform gamma-3 isoform 11

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (11) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC008541, AC026422
    Conserved Domains (2) summary
    pfam12605
    Location:253 → 342
    CK1gamma_C; Casein kinase 1 gamma C terminal
    cl21453
    Location:1 → 253
    PKc_like; Protein Kinases, catalytic domain

  10. NM_001364145.2 → NP_001351074.1  casein kinase I isoform gamma-3 isoform 12

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) differs in the 5' UTR and coding sequence, uses an alternate in-frame splice junction, and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (12) is shorter at the N-terminus and lacks two alternate internal segments compared to isoform 1.
    Source sequence(s)
    AC008541, AC026422
    Conserved Domains (2) summary
    pfam12605
    Location:254 → 311
    CK1gamma_C; Casein kinase 1 gamma C terminal
    cl21453
    Location:1 → 254
    PKc_like; Protein Kinases, catalytic domain

  11. NM_001364146.2 → NP_001351075.1  casein kinase I isoform gamma-3 isoform 13

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (13) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC008541, AC026422
    Conserved Domains (2) summary
    pfam12605
    Location:215 → 304
    CK1gamma_C; Casein kinase 1 gamma C terminal
    cl21453
    Location:1 → 215
    PKc_like; Protein Kinases, catalytic domain

  12. NM_001364147.2 → NP_001351076.1  casein kinase I isoform gamma-3 isoform 14

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (14) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 1.
    Source sequence(s)
    AC008541, AC026422
    Conserved Domains (2) summary
    pfam12605
    Location:215 → 272
    CK1gamma_C; Casein kinase 1 gamma C terminal
    cl21453
    Location:1 → 215
    PKc_like; Protein Kinases, catalytic domain

  13. NM_001364148.2 → NP_001351077.1  casein kinase I isoform gamma-3 isoform 15

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15) differs in the 5' UTR and coding sequence and lacks two alternate in-frame exons compared to variant 1. The resulting isoform (15) is shorter at the N-terminus and lacks two alternate internal segments compared to isoform 1.
    Source sequence(s)
    AC008541, AC026422
    Conserved Domains (2) summary
    pfam12605
    Location:215 → 272
    CK1gamma_C; Casein kinase 1 gamma C terminal
    cl21453
    Location:1 → 215
    PKc_like; Protein Kinases, catalytic domain

  14. NM_001364149.2 → NP_001351078.1  casein kinase I isoform gamma-3 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (6) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 1. Variants 6, 16, and 17 all encode the same isoform (6).
    Source sequence(s)
    AC008541, AC026422
    Consensus CDS
    CCDS59492.1
    Conserved Domains (2) summary
    pfam12605
    Location:253 → 310
    CK1gamma_C; Casein kinase 1 gamma C terminal
    cl21453
    Location:1 → 253
    PKc_like; Protein Kinases, catalytic domain

  15. NM_001364150.2 → NP_001351079.1  casein kinase I isoform gamma-3 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (6) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 1. Variants 6, 16, and 17 all encode the same isoform (6).
    Source sequence(s)
    AC008541, AC026422
    Consensus CDS
    CCDS59492.1
    Conserved Domains (2) summary
    pfam12605
    Location:253 → 310
    CK1gamma_C; Casein kinase 1 gamma C terminal
    cl21453
    Location:1 → 253
    PKc_like; Protein Kinases, catalytic domain

  16. NM_004384.5 → NP_004375.2  casein kinase I isoform gamma-3 isoform 1

    See identical proteins and their annotated locations for NP_004375.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AC008541, AC026422
    Consensus CDS
    CCDS4135.1
    UniProtKB/Swiss-Prot
    A8K040, B4DSH2, B7Z9Q4, E7EVD0, Q86WZ7, Q9Y6M3, Q9Y6M4
    Related
    ENSP00000354942.2, ENST00000361991.6
    Conserved Domains (2) summary
    cd14126
    Location:42 → 328
    STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
    pfam12605
    Location:328 → 417
    CK1gamma_C; Casein kinase 1 gamma C terminal

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    123512177..123617049
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017009060.2 → XP_016864549.1  casein kinase I isoform X1

  2. XM_047416765.1 → XP_047272721.1  casein kinase I isoform X19

  3. XM_047416768.1 → XP_047272724.1  casein kinase I isoform X20

  4. XM_017009059.2 → XP_016864548.1  casein kinase I isoform X1

  5. XM_047416755.1 → XP_047272711.1  casein kinase I isoform X11

  6. XM_047416763.1 → XP_047272719.1  casein kinase I isoform X17

  7. XM_047416764.1 → XP_047272720.1  casein kinase I isoform X18

  8. XM_047416757.1 → XP_047272713.1  casein kinase I isoform X12

  9. XM_017009069.2 → XP_016864558.1  casein kinase I isoform X19

    UniProtKB/Swiss-Prot
    Q9Y6M4
    Conserved Domains (2) summary
    cd14126
    Location:42 → 329
    STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
    pfam12605
    Location:329 → 386
    CK1gamma_C; Casein kinase 1 gamma C terminal

  10. XM_047416770.1 → XP_047272726.1  casein kinase I isoform X21

  11. XM_047416749.1 → XP_047272705.1  casein kinase I isoform X8

  12. XM_047416758.1 → XP_047272714.1  casein kinase I isoform X14

    UniProtKB/Swiss-Prot
    A8K040, B4DSH2, B7Z9Q4, E7EVD0, Q86WZ7, Q9Y6M3, Q9Y6M4

  13. XM_047416754.1 → XP_047272710.1  casein kinase I isoform X10

  14. XM_047416766.1 → XP_047272722.1  casein kinase I isoform X20

  15. XM_047416773.1 → XP_047272729.1  casein kinase I isoform X22

  16. XM_017009057.3 → XP_016864546.1  casein kinase I isoform X1

  17. XM_017009063.3 → XP_016864552.1  casein kinase I isoform X4

  18. XM_047416745.1 → XP_047272701.1  casein kinase I isoform X3

  19. XM_047416747.1 → XP_047272703.1  casein kinase I isoform X6

  20. XM_017009064.3 → XP_016864553.1  casein kinase I isoform X11

  21. XM_017009067.3 → XP_016864556.1  casein kinase I isoform X17

  22. XM_047416746.1 → XP_047272702.1  casein kinase I isoform X5

  23. XM_017009065.3 → XP_016864554.1  casein kinase I isoform X13

    Conserved Domains (2) summary
    cd14126
    Location:42 → 353
    STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
    pfam12605
    Location:353 → 399
    CK1gamma_C; Casein kinase 1 gamma C terminal

  24. XM_017009068.3 → XP_016864557.1  casein kinase I isoform X18

  25. XM_047416756.1 → XP_047272712.1  casein kinase I isoform X12

  26. XM_047416751.1 → XP_047272707.1  casein kinase I isoform X9

  27. XM_047416759.1 → XP_047272715.1  casein kinase I isoform X15

  28. XM_005271895.4 → XP_005271952.1  casein kinase I isoform X19

    See identical proteins and their annotated locations for XP_005271952.1

    UniProtKB/Swiss-Prot
    Q9Y6M4
    Conserved Domains (2) summary
    cd14126
    Location:42 → 329
    STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
    pfam12605
    Location:329 → 386
    CK1gamma_C; Casein kinase 1 gamma C terminal

  29. XM_005271892.4 → XP_005271949.1  casein kinase I isoform X8

    See identical proteins and their annotated locations for XP_005271949.1

    UniProtKB/Swiss-Prot
    Q9Y6M4
    Related
    ENSP00000334735.5, ENST00000345990.9
    Conserved Domains (2) summary
    cd14126
    Location:42 → 328
    STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
    pfam12605
    Location:328 → 417
    CK1gamma_C; Casein kinase 1 gamma C terminal

  30. XM_047416752.1 → XP_047272708.1  casein kinase I isoform X10

  31. XM_047416761.1 → XP_047272717.1  casein kinase I isoform X16

  32. XM_017009070.3 → XP_016864559.1  casein kinase I isoform X22

    Conserved Domains (2) summary
    cd14126
    Location:42 → 328
    STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
    pfam12605
    Location:328 → 385
    CK1gamma_C; Casein kinase 1 gamma C terminal

  33. XM_047416743.1 → XP_047272699.1  casein kinase I isoform X1

  34. XM_047416767.1 → XP_047272723.1  casein kinase I isoform X20

  35. XM_047416760.1 → XP_047272716.1  casein kinase I isoform X15

  36. XM_047416771.1 → XP_047272727.1  casein kinase I isoform X21

  37. XM_047416774.1 → XP_047272730.1  casein kinase I isoform X22

  38. XM_047416742.1 → XP_047272698.1  casein kinase I isoform X1

  39. XM_047416744.1 → XP_047272700.1  casein kinase I isoform X1

  40. XM_017009062.2 → XP_016864551.1  casein kinase I isoform X2

  41. XM_047416748.1 → XP_047272704.1  casein kinase I isoform X7

    UniProtKB/TrEMBL
    A0A8V8TKT3

  42. XM_047416750.1 → XP_047272706.1  casein kinase I isoform X8

  43. XM_047416772.1 → XP_047272728.1  casein kinase I isoform X21

  44. XM_047416769.1 → XP_047272725.1  casein kinase I isoform X20

  45. XM_047416775.1 → XP_047272731.1  casein kinase I isoform X22

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    124028409..124133283
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054351668.1 → XP_054207643.1  casein kinase I isoform X1

  2. XM_054351697.1 → XP_054207672.1  casein kinase I isoform X19

  3. XM_054351700.1 → XP_054207675.1  casein kinase I isoform X20

  4. XM_054351666.1 → XP_054207641.1  casein kinase I isoform X1

  5. XM_054351683.1 → XP_054207658.1  casein kinase I isoform X11

  6. XM_054351692.1 → XP_054207667.1  casein kinase I isoform X17

  7. XM_054351694.1 → XP_054207669.1  casein kinase I isoform X18

  8. XM_054351685.1 → XP_054207660.1  casein kinase I isoform X12

  9. XM_054351696.1 → XP_054207671.1  casein kinase I isoform X19

  10. XM_054351702.1 → XP_054207677.1  casein kinase I isoform X21

  11. XM_054351677.1 → XP_054207652.1  casein kinase I isoform X8

  12. XM_054351687.1 → XP_054207662.1  casein kinase I isoform X14

    UniProtKB/Swiss-Prot
    A8K040, B4DSH2, B7Z9Q4, E7EVD0, Q86WZ7, Q9Y6M3, Q9Y6M4

  13. XM_054351681.1 → XP_054207656.1  casein kinase I isoform X10

  14. XM_054351698.1 → XP_054207673.1  casein kinase I isoform X20

  15. XM_054351706.1 → XP_054207681.1  casein kinase I isoform X22

  16. XM_054351664.1 → XP_054207639.1  casein kinase I isoform X1

  17. XM_054351672.1 → XP_054207647.1  casein kinase I isoform X4

  18. XM_054351671.1 → XP_054207646.1  casein kinase I isoform X3

  19. XM_054351674.1 → XP_054207649.1  casein kinase I isoform X6

  20. XM_054351682.1 → XP_054207657.1  casein kinase I isoform X11

  21. XM_054351691.1 → XP_054207666.1  casein kinase I isoform X17

  22. XM_054351673.1 → XP_054207648.1  casein kinase I isoform X5

  23. XM_054351686.1 → XP_054207661.1  casein kinase I isoform X13

  24. XM_054351693.1 → XP_054207668.1  casein kinase I isoform X18

  25. XM_054351684.1 → XP_054207659.1  casein kinase I isoform X12

  26. XM_054351679.1 → XP_054207654.1  casein kinase I isoform X9

  27. XM_054351688.1 → XP_054207663.1  casein kinase I isoform X15

  28. XM_054351695.1 → XP_054207670.1  casein kinase I isoform X19

  29. XM_054351676.1 → XP_054207651.1  casein kinase I isoform X8

  30. XM_054351680.1 → XP_054207655.1  casein kinase I isoform X10

  31. XM_054351690.1 → XP_054207665.1  casein kinase I isoform X16

  32. XM_054351705.1 → XP_054207680.1  casein kinase I isoform X22

  33. XM_054351667.1 → XP_054207642.1  casein kinase I isoform X1

  34. XM_054351699.1 → XP_054207674.1  casein kinase I isoform X20

  35. XM_054351689.1 → XP_054207664.1  casein kinase I isoform X15

  36. XM_054351703.1 → XP_054207678.1  casein kinase I isoform X21

  37. XM_054351707.1 → XP_054207682.1  casein kinase I isoform X22

  38. XM_054351665.1 → XP_054207640.1  casein kinase I isoform X1

  39. XM_054351669.1 → XP_054207644.1  casein kinase I isoform X1

  40. XM_054351670.1 → XP_054207645.1  casein kinase I isoform X2

  41. XM_054351675.1 → XP_054207650.1  casein kinase I isoform X7

    UniProtKB/TrEMBL
    A0A8V8TKT3

  42. XM_054351678.1 → XP_054207653.1  casein kinase I isoform X8

  43. XM_054351704.1 → XP_054207679.1  casein kinase I isoform X21

  44. XM_054351701.1 → XP_054207676.1  casein kinase I isoform X20

  45. XM_054351708.1 → XP_054207683.1  casein kinase I isoform X22

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001044722.1: Suppressed sequence

    Description
    NM_001044722.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y6M4.2 GenPept UniProtKB/Swiss-Prot:Q9Y6M4

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