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Gcsam germinal center associated, signaling and motility [ Mus musculus (house mouse) ]

Gene ID: 14525, updated on 5-Mar-2024

Summary

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Official Symbol
Gcsamprovided by MGI
Official Full Name
germinal center associated, signaling and motilityprovided by MGI
Primary source
MGI:MGI:102969
See related
Ensembl:ENSMUSG00000022659 AllianceGenome:MGI:102969
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
M17; Gcet; Gcet2; M17-L
Summary
Predicted to enable actin binding activity; myosin II binding activity; and protein kinase binding activity. Predicted to be involved in negative regulation of lymphocyte migration and regulation of B cell receptor signaling pathway. Predicted to be located in cytoplasm and plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and integumental system. Orthologous to human GCSAM (germinal center associated signaling and motility). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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See Gcsam in Genome Data Viewer
Location:
16 29.72 cM; 16 B5
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (45430803..45443230)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (45610440..45622867)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene TNF receptor associated factor 4 pseudogene Neighboring gene solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1 Neighboring gene cDNA sequence, BC016579 Neighboring gene transmembrane serine protease 7 Neighboring gene STARR-seq mESC enhancer starr_40918 Neighboring gene STARR-seq mESC enhancer starr_40919

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. M17: a novel gene expressed in germinal centers. Christoph T, et al. Int Immunol, 1994 Aug. PMID 7981148
  2. Identification of an Sp factor-dependent promoter in GCET, a gene expressed at high levels in germinal center B cells. Steinke JW, et al. Mol Immunol, 2004 Nov. PMID 15482850
  3. Protocol for using signal peptide differential display and representational difference analysis to isolate differentially expressed cDNAs from fetal mouse brain. Eriksson A, et al. Brain Res Brain Res Protoc, 2001 Feb. PMID 11223410
  4. M17, a gene specific for germinal center (GC) B cells and a prognostic marker for GC B-cell lymphomas, is dispensable for the GC reaction in mice. Schenten D, et al. Blood, 2006 Jun 15. PMID 16493007, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Assays identified a non-consensus binding site for Sp factors near sites of transcriptional initiation. The site binds Spl and Sp3 in nuclear extracts.
    Title: Identification of an Sp factor-dependent promoter in GCET, a gene expressed at high levels in germinal center B cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding ISO
Inferred from Sequence Orthology
more info
  
enables myosin II binding ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of lymphocyte migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of lymphocyte migration ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of B cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of B cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of lymphocyte migration IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
germinal center-associated signaling and motility protein
Names
germinal center B-cell-expressed transcript 2 protein
germinal center expressed transcript 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159297.1 → NP_001152769.1  germinal center-associated signaling and motility protein isoform 1

    See identical proteins and their annotated locations for NP_001152769.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
    Source sequence(s)
    AK036553, AY500830, U13263
    Consensus CDS
    CCDS49861.1
    UniProtKB/Swiss-Prot
    Q60691, Q6RFH4, Q8CB90
    Related
    ENSMUSP00000123853.2, ENSMUST00000161347.9
    Conserved Domains (1) summary
    pfam15666
    Location:74 → 155
    HGAL; Germinal center-associated lymphoma

  2. NM_008099.4 → NP_032125.3  germinal center-associated signaling and motility protein isoform 2

    See identical proteins and their annotated locations for NP_032125.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. This difference results in a protein (isoform 2) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK036553, U13263
    Consensus CDS
    CCDS28199.1
    UniProtKB/Swiss-Prot
    Q6RFH4
    Related
    ENSMUSP00000023339.5, ENSMUST00000023339.5
    Conserved Domains (1) summary
    pfam15666
    Location:52 → 133
    HGAL; Germinal center-associated lymphoma

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    45430803..45443230
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6RFH4.1 GenPept UniProtKB/Swiss-Prot:Q6RFH4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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