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F fusion [ Henipavirus hendraense ]

Gene ID: 1446467, updated on 18-Aug-2023

Summary

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Gene symbol
F
Gene description
fusion
Locus tag
Hvgp4
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Henipavirus hendraense
Lineage
Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina; Monjiviricetes; Mononegavirales; Paramyxoviridae; Orthoparamyxovirinae; Henipavirus
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Genomic context

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Sequence:
NC_001906.3 (6346..8676)

NC_001906.3Genomic Context describing neighboring genes Neighboring gene nonstructural protein C;nonstructural protein V;phosphoprotein P Neighboring gene matrix Neighboring gene glycoprotein Neighboring gene polymerase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001906.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mutations in the Transmembrane Domain and Cytoplasmic Tail of Hendra Virus Fusion Protein Disrupt Virus-Like-Particle Assembly. Cifuentes-Muñoz N, et al. J Virol, 2017 Jul 15. PMID 28468881, Free PMC Article
  2. Hendra virus fusion protein transmembrane domain contributes to pre-fusion protein stability. Webb S, et al. J Biol Chem, 2017 Apr 7. PMID 28213515, Free PMC Article
  3. Beyond anchoring: the expanding role of the hendra virus fusion protein transmembrane domain in protein folding, stability, and function. Smith EC, et al. J Virol, 2012 Mar. PMID 22238302, Free PMC Article
  4. Residues in the hendra virus fusion protein transmembrane domain are critical for endocytic recycling. Popa A, et al. J Virol, 2012 Mar. PMID 22238299, Free PMC Article
  5. Side chain packing below the fusion peptide strongly modulates triggering of the Hendra virus F protein. Smith EC, et al. J Virol, 2010 Oct. PMID 20702638, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. study found matrix (M) and F proteins each induced particle release when they were expressed alone but their coexpression led to coordinated assembly of virus-like particles (VLPs) that were morphologically and physically distinct from M-only or F-only VLPs; mutations to F protein transmembrane domain or cytoplasmic tail that disrupted endocytic trafficking led to failure of F to function with M for VLP assembly
    Title: Mutations in the Transmembrane Domain and Cytoplasmic Tail of Hendra Virus Fusion Protein Disrupt Virus-Like-Particle Assembly.
  2. data suggest that the heptad repeat LIZ contributed to TM-TM association and is important for F protein function and pre-fusion stability.
    Title: Hendra virus fusion protein transmembrane domain contributes to pre-fusion protein stability.
  3. N-terminal end of the transmembrane domain of the F protein plays critical roles in fusion.
    Title: Beyond anchoring: the expanding role of the hendra virus fusion protein transmembrane domain in protein folding, stability, and function.
  4. Residues S490 and Y498 of F protein transmembrane domain are critical for endocytic recycling.
    Title: Residues in the hendra virus fusion protein transmembrane domain are critical for endocytic recycling.
  5. Mutation of a histidine predicted to lie near the fusion peptide to alanine greatly reduced fusion despite wild-type cell surface expression levels, while asparagine substitution resulted in a moderate restoration in fusion levels.
    Title: Side chain packing below the fusion peptide strongly modulates triggering of the Hendra virus F protein.
  6. These results suggest that the critical F-G interactions occur only after the initial steps of synthesis and cellular transport.
    Title: Differential rates of protein folding and cellular trafficking for the Hendra virus F and G proteins: implications for F-G complex formation.
  7. role in protein folding and transport as well as membrane fusion
    Title: Role of N-linked glycosylation of the Hendra virus fusion protein.
  8. crystallographic analysis of the fusion core from Nipah virus and Hendra virus
    Title: Crystallization and preliminary crystallographic analysis of the fusion core from two new zoonotic paramyxoviruses, Nipah virus and Hendra virus.
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General gene information

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Homology

General protein information

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Preferred Names
fusion

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001906.3 Reference assembly

    Range
    6346..8676
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_047111.2 fusion [Henipavirus hendraense]

    See identical proteins and their annotated locations for NP_047111.2

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O89342, Q66761
    UniProtKB/TrEMBL
    F4YH70
    Conserved Domains (1) summary
    pfam00523
    Location:29 → 488
    Fusion_gly; Fusion glycoprotein F0
Nucleotide Protein
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