ptpra protein tyrosine phosphatase receptor type A [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ptpraprovided by ZNC
Official Full Name: protein tyrosine phosphatase receptor type Aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-020107-1
See related: Ensembl:ENSDARG00000001769 AllianceGenome:ZFIN:ZDB-GENE-020107-1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: RPTP[a]
Summary: Predicted to enable protein tyrosine phosphatase activity. Involved in fin regeneration. Acts upstream of or within convergent extension involved in gastrulation; regulation of protein kinase activity; and retina development in camera-type eye. Predicted to be located in plasma membrane. Is expressed in blastomere; head; nervous system; and pectoral fin. Orthologous to human PTPRA (protein tyrosine phosphatase receptor type A). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 21

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	21	NC_007132.7 (15756531..15817237)
105	previous assembly	GRCz10 (GCF_000002035.5)	21	NC_007132.6 (15660572..15720510)

Chromosome 21 - NC_007132.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ptpra protein, zebrafish, signaling is essential for convergence and extension cell movements during gastrulation.
Title: RPTPalpha and PTPepsilon signaling via Fyn/Yes and RhoA is essential for zebrafish convergence and extension cell movements during gastrulation.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables phosphoprotein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within convergent extension involved in gastrulation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within convergent extension involved in gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in fin regeneration	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein dephosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within retina development in camera-type eye	IMP Inferred from Mutant Phenotype more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: receptor-type tyrosine-protein phosphatase alpha

Names: protein-tyrosine phosphatase alpha

NP_571963.2

EC 3.1.3.48

XP_021324422.1

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131888.2 → NP_571963.2 receptor-type tyrosine-protein phosphatase alpha precursor

Status: VALIDATED

Source sequence(s)

CR847785, EB928445

UniProtKB/TrEMBL

A0A8M1P790, F1QE38

Related

ENSDARP00000003403.9, ENSDART00000026903.11

Conserved Domains (3) summary

PHA03255
Location:55 → 176

PHA03255; BDLF3; Provisional

smart00194
Location:269 → 529

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:589 → 819

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007132.7 Reference GRCz11 Primary Assembly

Range

15756531..15817237

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021468747.2 → XP_021324422.1 receptor-type tyrosine-protein phosphatase alpha isoform X1

UniProtKB/TrEMBL

A0A8M9P361

Conserved Domains (3) summary

smart00194
Location:265 → 525

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:585 → 815

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cl25495
Location:55 → 174

Endomucin