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Plcd4 phospholipase C, delta 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 140693, updated on 10-Oct-2024

Summary

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Official Symbol
Plcd4provided by RGD
Official Full Name
phospholipase C, delta 4provided by RGD
Primary source
RGD:621025
See related
EnsemblRapid:ENSRNOG00000016361 AllianceGenome:RGD:621025
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables phosphatidylinositol phospholipase C activity. Predicted to be involved in phosphatidylinositol-mediated signaling and small GTPase mediated signal transduction. Predicted to act upstream of or within acrosome reaction. Predicted to be located in cytosol; endoplasmic reticulum; and plasma membrane. Orthologous to human PLCD4 (phospholipase C delta 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 118.8), Testes (RPKM 71.2) and 6 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Plcd4 in Genome Data Viewer
Location:
9q33
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (83564616..83613742)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (76115523..76158602)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (81816395..81844364)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 37 Neighboring gene transfer RNA proline (anticodon AGG) 59 Neighboring gene CCR4-NOT transcription complex subunit 9 Neighboring gene zinc finger protein 142 Neighboring gene BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone Neighboring gene ring finger protein 25 Neighboring gene serine/threonine kinase 36

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A novel phospholipase C delta4 (PLCdelta4) splice variant as a negative regulator of PLC. Nagano K, et al. J Biol Chem, 1999 Jan 29. PMID 9915823
  2. A new phospholipase C delta 4 is induced at S-phase of the cell cycle and appears in the nucleus. Liu N, et al. J Biol Chem, 1996 Jan 5. PMID 8550586
  3. Molecular cloning, splice variants, expression, and purification of phospholipase C-delta 4. Lee SB, et al. J Biol Chem, 1996 Jan 5. PMID 8550568
  4. Requirement of phospholipase Cdelta4 for the zona pellucida-induced acrosome reaction. Fukami K, et al. Science, 2001 May 4. PMID 11340203
  5. A biochemical and genetic discovery pipeline identifies PLCδ4b as a nonreceptor activator of heterotrimeric G-proteins. Maziarz M, et al. J Biol Chem, 2018 Nov 2. PMID 30194280, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G-protein alpha-subunit binding ISO
Inferred from Sequence Orthology
more info
  
enables G-protein alpha-subunit binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol phospholipase C activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol phospholipase C activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol phospholipase C activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in acrosome reaction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within acrosome reaction ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction TAS
Traceable Author Statement
more info
 PubMed 
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in small GTPase-mediated signal transduction ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4
Names
PLC-delta-4
phosphoinositide phospholipase C-delta-4
NP_542419.1
XP_006245198.1
XP_006245199.1
XP_006245200.1
XP_008765404.1
XP_008765406.1
XP_008765409.1
XP_008765410.1
XP_008765411.1
XP_008765412.1
XP_038938901.1
XP_038938902.1
XP_038938903.1
XP_063122672.1
XP_063122673.1
XP_063122674.1
XP_063122675.1
XP_063122676.1
XP_063122677.1
XP_063122678.1
XP_063122679.1
XP_063122680.1
XP_063122681.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080688.1 → NP_542419.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4

    See identical proteins and their annotated locations for NP_542419.1

    Status: PROVISIONAL

    Source sequence(s)
    U16655
    UniProtKB/Swiss-Prot
    Q62711, Q63693
    UniProtKB/TrEMBL
    A0A8L2QKX9
    Related
    ENSRNOP00000039708.4, ENSRNOT00000041407.6
    Conserved Domains (8) summary
    cd00275
    Location:636 → 761
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    PLN02228
    Location:207 → 749
    PLN02228; Phosphoinositide phospholipase C
    pfam00169
    Location:17 → 123
    PH; PH domain
    pfam09279
    Location:207 → 289
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    pfam13499
    Location:175 → 231
    EF-hand_7; EF-hand domain pair
    pfam14788
    Location:153 → 202
    EF-hand_10; EF hand
    cl14615
    Location:289 → 606
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    cl17171
    Location:18 → 133
    PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    83564616..83613742
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008767187.4 → XP_008765409.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X2

    UniProtKB/TrEMBL
    A0A8L2QKX9
    Conserved Domains (8) summary
    cd00275
    Location:667 → 818
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    PLN02228
    Location:207 → 775
    PLN02228; Phosphoinositide phospholipase C
    pfam00169
    Location:17 → 123
    PH; PH domain
    pfam09279
    Location:207 → 289
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    pfam13499
    Location:175 → 231
    EF-hand_7; EF-hand domain pair
    pfam14788
    Location:153 → 202
    EF-hand_10; EF hand
    cl14615
    Location:289 → 637
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    cl17171
    Location:18 → 133
    PH-like; Pleckstrin homology-like domain

  2. XM_063266604.1 → XP_063122674.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X4

  3. XM_008767184.4 → XP_008765406.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1

    See identical proteins and their annotated locations for XP_008765406.1

    UniProtKB/TrEMBL
    A0A8L2QKX9
    Conserved Domains (4) summary
    PLN02228
    Location:207 → 776
    PLN02228; Phosphoinositide phospholipase C
    pfam14788
    Location:153 → 202
    EF-hand_10; EF hand
    cl14615
    Location:289 → 638
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    cl17171
    Location:18 → 133
    PH-like; Pleckstrin homology-like domain

  4. XM_063266602.1 → XP_063122672.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1

  5. XM_039082973.2 → XP_038938901.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1

    UniProtKB/TrEMBL
    A0A8L2QKX9
    Conserved Domains (4) summary
    PLN02228
    Location:207 → 776
    PLN02228; Phosphoinositide phospholipase C
    pfam14788
    Location:153 → 202
    EF-hand_10; EF hand
    cl14615
    Location:289 → 638
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    cl17171
    Location:18 → 133
    PH-like; Pleckstrin homology-like domain

  6. XM_008767188.4 → XP_008765410.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X3

    UniProtKB/TrEMBL
    A0A8L2QKX9
    Conserved Domains (8) summary
    cd00275
    Location:650 → 801
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    PLN02228
    Location:207 → 758
    PLN02228; Phosphoinositide phospholipase C
    pfam00169
    Location:17 → 123
    PH; PH domain
    pfam09279
    Location:207 → 289
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    pfam13499
    Location:175 → 231
    EF-hand_7; EF-hand domain pair
    pfam14788
    Location:153 → 202
    EF-hand_10; EF hand
    cl14615
    Location:289 → 620
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    cl17171
    Location:18 → 133
    PH-like; Pleckstrin homology-like domain

  7. XM_063266608.1 → XP_063122678.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X8

  8. XM_039082975.2 → XP_038938903.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X5

    UniProtKB/TrEMBL
    A0A8L2QKX9
    Conserved Domains (4) summary
    PLN02228
    Location:207 → 781
    PLN02228; Phosphoinositide phospholipase C
    pfam14788
    Location:153 → 202
    EF-hand_10; EF hand
    cl14615
    Location:289 → 638
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    cl17171
    Location:18 → 133
    PH-like; Pleckstrin homology-like domain

  9. XM_063266605.1 → XP_063122675.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X5

  10. XM_008767189.4 → XP_008765411.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X5

    UniProtKB/TrEMBL
    A0A8L2QKX9
    Related
    ENSRNOP00000102316.1, ENSRNOT00000132597.1
    Conserved Domains (4) summary
    PLN02228
    Location:207 → 781
    PLN02228; Phosphoinositide phospholipase C
    pfam14788
    Location:153 → 202
    EF-hand_10; EF hand
    cl14615
    Location:289 → 638
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    cl17171
    Location:18 → 133
    PH-like; Pleckstrin homology-like domain

  11. XM_063266607.1 → XP_063122677.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X7

  12. XM_063266606.1 → XP_063122676.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X6

  13. XM_008767190.4 → XP_008765412.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X6

    UniProtKB/TrEMBL
    A0A8L2QKX9
    Conserved Domains (8) summary
    cd00275
    Location:636 → 787
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    PLN02228
    Location:207 → 744
    PLN02228; Phosphoinositide phospholipase C
    pfam00169
    Location:17 → 123
    PH; PH domain
    pfam09279
    Location:207 → 289
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    pfam13499
    Location:175 → 231
    EF-hand_7; EF-hand domain pair
    pfam14788
    Location:153 → 202
    EF-hand_10; EF hand
    cl14615
    Location:289 → 606
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    cl17171
    Location:18 → 133
    PH-like; Pleckstrin homology-like domain

  14. XM_063266611.1 → XP_063122681.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X10

  15. XM_063266610.1 → XP_063122680.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X9

    UniProtKB/Swiss-Prot
    Q62711, Q63693

  16. XM_063266609.1 → XP_063122679.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X9

    UniProtKB/Swiss-Prot
    Q62711, Q63693

  17. XM_008767182.4 → XP_008765404.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1

    See identical proteins and their annotated locations for XP_008765404.1

    UniProtKB/TrEMBL
    A0A8L2QKX9
    Conserved Domains (4) summary
    PLN02228
    Location:207 → 776
    PLN02228; Phosphoinositide phospholipase C
    pfam14788
    Location:153 → 202
    EF-hand_10; EF hand
    cl14615
    Location:289 → 638
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    cl17171
    Location:18 → 133
    PH-like; Pleckstrin homology-like domain

  18. XM_006245136.5 → XP_006245198.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1

    See identical proteins and their annotated locations for XP_006245198.1

    UniProtKB/TrEMBL
    A0A8L2QKX9
    Conserved Domains (4) summary
    PLN02228
    Location:207 → 776
    PLN02228; Phosphoinositide phospholipase C
    pfam14788
    Location:153 → 202
    EF-hand_10; EF hand
    cl14615
    Location:289 → 638
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    cl17171
    Location:18 → 133
    PH-like; Pleckstrin homology-like domain

  19. XM_006245137.5 → XP_006245199.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1

    See identical proteins and their annotated locations for XP_006245199.1

    UniProtKB/TrEMBL
    A0A8L2QKX9
    Conserved Domains (4) summary
    PLN02228
    Location:207 → 776
    PLN02228; Phosphoinositide phospholipase C
    pfam14788
    Location:153 → 202
    EF-hand_10; EF hand
    cl14615
    Location:289 → 638
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    cl17171
    Location:18 → 133
    PH-like; Pleckstrin homology-like domain

  20. XM_063266603.1 → XP_063122673.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1

  21. XM_006245138.5 → XP_006245200.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1

    See identical proteins and their annotated locations for XP_006245200.1

    UniProtKB/TrEMBL
    A0A8L2QKX9
    Conserved Domains (4) summary
    PLN02228
    Location:207 → 776
    PLN02228; Phosphoinositide phospholipase C
    pfam14788
    Location:153 → 202
    EF-hand_10; EF hand
    cl14615
    Location:289 → 638
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    cl17171
    Location:18 → 133
    PH-like; Pleckstrin homology-like domain

  22. XM_039082974.2 → XP_038938902.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1

    UniProtKB/TrEMBL
    A0A8L2QKX9
    Conserved Domains (4) summary
    PLN02228
    Location:207 → 776
    PLN02228; Phosphoinositide phospholipase C
    pfam14788
    Location:153 → 202
    EF-hand_10; EF hand
    cl14615
    Location:289 → 638
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    cl17171
    Location:18 → 133
    PH-like; Pleckstrin homology-like domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q62711.1 GenPept UniProtKB/Swiss-Prot:Q62711

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