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A1bg alpha-1-B glycoprotein [ Rattus norvegicus (Norway rat) ]

Gene ID: 140656, updated on 2-Nov-2024

Summary

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Official Symbol
A1bgprovided by RGD
Official Full Name
alpha-1-B glycoproteinprovided by RGD
Primary source
RGD:69417
See related
EnsemblRapid:ENSRNOG00000004692 AllianceGenome:RGD:69417
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
C44
Summary
Predicted to be involved in immune response-regulating signaling pathway. Predicted to be located in extracellular region. Predicted to be active in plasma membrane. Orthologous to human A1BG (alpha-1-B glycoprotein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward (RPKM 3425.0) See more
Orthologs
human mouse all
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Genomic context

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See A1bg in Genome Data Viewer
Location:
7q33
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (94383333..94387922, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (92493934..92498460, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (102294805..102298522, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene LRAT domain containing 2 Neighboring gene uncharacterized LOC134479737 Neighboring gene growth hormone inducible transmembrane protein, pseudogene 1 Neighboring gene uncharacterized LOC120093668 Neighboring gene uncharacterized LOC120093667 Neighboring gene uncharacterized LOC120093670 Neighboring gene uncharacterized LOC103692925

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cloning of a novel growth hormone-regulated rat complementary deoxyribonucleic acid with homology to the human alpha1B-glycoprotein, characterizing a new protein family. Gardmo C, et al. Endocrinology, 2001 Jun. PMID 11356721
  2. Identification and characterization of differentially expressed genes in the early response phase during liver regeneration. Xu W, et al. Biochem Biophys Res Commun, 2000 Nov 19. PMID 11097837
  3. Amino acid sequence of human plasma alpha 1B-glycoprotein: homology to the immunoglobulin supergene family. Ishioka N, et al. Proc Natl Acad Sci U S A, 1986 Apr. PMID 3458201, Free PMC Article
  4. Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation. Barallobre-Barreiro J, et al. Circulation, 2016 Sep 13. PMID 27559042, Free PMC Article
  5. Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability. Bastos-Amador P, et al. J Proteomics, 2012 Jun 27. PMID 22516433

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in immune response-regulating signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
alpha-1B-glycoprotein
Names
liver regeneration-related protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022258.3 → NP_071594.3  alpha-1B-glycoprotein precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/Swiss-Prot
    Q5EBD6, Q9EPH1, Q9JKL2
    UniProtKB/TrEMBL
    A0A8I6A5Z6, A6HRN5
    Related
    ENSRNOP00000006273.4, ENSRNOT00000006273.8
    Conserved Domains (3) summary
    pfam13895
    Location:233 → 311
    Ig_2; Immunoglobulin domain
    cd00096
    Location:29 → 33
    Ig; Ig strand A [structural motif]
    cl11960
    Location:29 → 125
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    94383333..94387922 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039078317.2 → XP_038934245.1  alpha-1B-glycoprotein isoform X1

    UniProtKB/TrEMBL
    A6HRN6
    Conserved Domains (3) summary
    pfam13895
    Location:233 → 311
    Ig_2; Immunoglobulin domain
    cd00096
    Location:29 → 33
    Ig; Ig strand A [structural motif]
    cl11960
    Location:29 → 125
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9EPH1.2 GenPept UniProtKB/Swiss-Prot:Q9EPH1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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