sox10 SRY-box transcription factor 10 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: sox10provided by ZNC
Official Full Name: SRY-box transcription factor 10provided by ZNC
Primary source: ZFIN:ZDB-GENE-011207-1
See related: Ensembl:ENSDARG00000077467 AllianceGenome:ZFIN:ZDB-GENE-011207-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cls/sox10; zgc:100757
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in olfactory bulb development. Acts upstream of or within with a positive effect on iridophore differentiation; melanocyte differentiation; and xanthophore differentiation. Acts upstream of or within several processes, including glial cell differentiation; inner ear development; and mesenchymal cell differentiation. Predicted to be active in nucleus. Is expressed in several structures, including embryonic structure; glioblast; head; nervous system; and neural crest. Used to study Hirschsprung's disease and Waardenburg syndrome. Human ortholog(s) of this gene implicated in Kallmann syndrome; PCWH syndrome; Waardenburg syndrome type 2E; and Waardenburg syndrome type 4C. Orthologous to human SOX10 (SRY-box transcription factor 10). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (1492174..1501252)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (2013057..2022135)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A gene regulatory network combining Pax3/7, Sox10 and Mitf generates diverse pigment cell types in medaka and zebrafish.
Title: A gene regulatory network combining Pax3/7, Sox10 and Mitf generates diverse pigment cell types in medaka and zebrafish.
Zebrafish anterior segment mesenchyme progenitors are defined by function of tfap2a but not sox10.
Title: Zebrafish anterior segment mesenchyme progenitors are defined by function of tfap2a but not sox10.
Functional in vivo characterization of sox10 enhancers in neural crest and melanoma development.
Title: Functional in vivo characterization of sox10 enhancers in neural crest and melanoma development.
Adult sox10(+) Cardiomyocytes Contribute to Myocardial Regeneration in the Zebrafish.
Title: Adult sox10(+) Cardiomyocytes Contribute to Myocardial Regeneration in the Zebrafish.
We genetically ablate the NC using double mutants of tfap2a;tfap2c or remove specific subsets of the NC with sox10 and mitfa knockouts and characterise genome-wide gene expression levels across multiple time points.
Title: The gene regulatory basis of genetic compensation during neural crest induction.
findings reveal surprising diversity in even the mode of the interactions between Sox5 and Sox10 governing specification of pigment cell types in medaka and zebrafish, and suggest that this is related to the evolution of a fourth pigment cell type
Title: Distinct interactions of Sox5 and Sox10 in fate specification of pigment cells in medaka and zebrafish.
This study reveals a unique regulatory mechanism, the Rgs2-Ppard-Sox10 signaling cascade, and defines a key molecular regulator, Rgs2, in neural crest development.
Title: Regulator of G protein signaling 2 (Rgs2) regulates neural crest development through Pparδ-Sox10 cascade.
Our zebrafish CHARGE model thus reveals important regulatory roles for Chd7 at multiple points of neural crest development viz., migration, fate choice and differentiation and we suggest that sox10 deregulation is an important driver of the neural crest-derived aspects of Chd7 dependent CHARGE syndrome.
Title: Rescue of neural crest-derived phenotypes in a zebrafish CHARGE model by Sox10 downregulation.
Demonstrate a contribution of sox10-dependent cranial neural crest to olfactory sensory neurons in zebrafish and provide important insights into the assembly of the nascent olfactory system.
Title: Sox10-dependent neural crest origin of olfactory microvillous neurons in zebrafish.
Data indicate that the optical flow analysis detected and quantified significant differences in the cell migrations of Sox10:EGFP positive cranial neural crest cells in ethanol treated versus untreated embryos.
Title: Quantitative analysis of cell migration using optical flow.

Submit: New GeneRIF Correction See all GeneRIFs (19)

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Schwann cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within Schwann cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cranial skeletal system development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within developmental pigmentation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in enteric nervous system development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within enteric nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within glial cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within glial cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within host-mediated regulation of intestinal microbiota composition	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inner ear development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within inner ear development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within_positive_effect iridophore differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within melanocyte differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within_positive_effect melanocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in morphogenesis of an epithelium	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within myelination in peripheral nervous system	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of neurogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neural crest cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neural crest cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neural crest cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neural crest formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in olfactory bulb development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within oligodendrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within otic vesicle morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within otolith development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peripheral nervous system development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within pigment cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pigmentation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within retina development in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within semicircular canal morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within_positive_effect xanthophore differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transcription factor SOX-10

Names: SRY (sex determining region Y)-box 10; SRY-box containing gene 10; cls; colorless; colourless; colourless/sox10; golas; gos; sox10b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131875.1 → NP_571950.1 transcription factor SOX-10

See identical proteins and their annotated locations for NP_571950.1

Status: PROVISIONAL

Source sequence(s)

AF402677

UniProtKB/TrEMBL

B3DKJ2, F6P4Y0, Q90XD1

Related

ENSDARP00000100237.2, ENSDART00000112979.3

Conserved Domains (2) summary

cd01388
Location:107 → 177

SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...

pfam12444
Location:13 → 97

Sox_N; Sox developmental protein N terminal