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Drg1 developmentally regulated GTP binding protein 1 [ Mus musculus (house mouse) ]

Gene ID: 13494, updated on 17-Aug-2024

Summary

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Official Symbol
Drg1provided by MGI
Official Full Name
developmentally regulated GTP binding protein 1provided by MGI
Primary source
MGI:MGI:1343297
See related
Ensembl:ENSMUSG00000020457 AllianceGenome:MGI:1343297
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DRG-1; Nedd3; NEDD-3
Summary
Predicted to enable several functions, including GTP binding activity; GTPase activity; and potassium ion binding activity. Predicted to be involved in cytoplasmic translation; positive regulation of microtubule polymerization; and regulation of mitotic spindle assembly. Predicted to be located in cytosol and nuclear body. Predicted to be part of polysome. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; ear; genitourinary system; and integumental system. Orthologous to human DRG1 (developmentally regulated GTP binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 29.0), CNS E11.5 (RPKM 28.8) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 A1; 11 2.23 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (3199907..3221882, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (3249907..3266464, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene Sfi1 homolog, spindle assembly associated (yeast) Neighboring gene STARR-positive B cell enhancer ABC_E6943 Neighboring gene Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (fox derived), pseudogene 2 Neighboring gene eukaryotic translation initiation factor 4E nuclear import factor 1 Neighboring gene predicted gene, 51877 Neighboring gene STARR-seq mESC enhancer starr_28343 Neighboring gene STARR-seq mESC enhancer starr_28345 Neighboring gene POZ (BTB) and AT hook containing zinc finger 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:3214183-3214292 Neighboring gene predicted gene 12592 Neighboring gene predicted gene 11944 Neighboring gene STARR-positive B cell enhancer ABC_E5203 Neighboring gene STARR-positive B cell enhancer ABC_E2345 Neighboring gene STARR-positive B cell enhancer ABC_E3929 Neighboring gene phosphoinositide-3-kinase interacting protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Expression of DRG during murine embryonic development. Sazuka T, et al. Biochem Biophys Res Commun, 1992 Nov 30. PMID 1280421
  2. Structure of the human protein kinase MPSK1 reveals an atypical activation loop architecture. Eswaran J, et al. Structure, 2008 Jan. PMID 18184589, Free PMC Article
  3. DRG: a novel developmentally regulated GTP-binding protein. Sazuka T, et al. Biochem Biophys Res Commun, 1992 Nov 30. PMID 1449490
  4. SCL binds the human homologue of DRG in vivo. Zhao XF, et al. Biochim Biophys Acta, 1998 Nov 19. PMID 9824680
  5. DRG represents a family of two closely related GTP-binding proteins. Li B, et al. Biochim Biophys Acta, 2000 Apr 25. PMID 10760581

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inactivation of DRG1, encoding a translation factor GTPase, causes a recessive neurodevelopmental disorder.
    Title: Inactivation of DRG1, encoding a translation factor GTPase, causes a recessive neurodevelopmental disorder.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables potassium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytoplasmic translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of microtubule polymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mitotic spindle assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
developmentally-regulated GTP-binding protein 1
Names
GTP-binding protein
TRAFAC GTPase DRG1
neural precursor cell expressed developmentally down-regulated protein 3
translation factor GTPase DRG1
NP_031905.1
XP_017169738.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007879.2 → NP_031905.1  developmentally-regulated GTP-binding protein 1

    See identical proteins and their annotated locations for NP_031905.1

    Status: VALIDATED

    Source sequence(s)
    AL671968
    Consensus CDS
    CCDS24355.1
    UniProtKB/Swiss-Prot
    P32233
    UniProtKB/TrEMBL
    Q5NBZ3, Q8BNS0, Q8CHR8
    Related
    ENSMUSP00000020741.6, ENSMUST00000020741.12
    Conserved Domains (1) summary
    COG1163
    Location:1 → 367
    Rbg1; Ribosome-interacting GTPase 1 [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    3199907..3221882 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017314249.3 → XP_017169738.1  developmentally-regulated GTP-binding protein 1 isoform X1

    UniProtKB/TrEMBL
    Q8BNS0, Q8CHR8
    Conserved Domains (1) summary
    COG1163
    Location:1 → 334
    Rbg1; Ribosome-interacting GTPase 1 [Translation, ribosomal structure and biogenesis]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32233.1 GenPept UniProtKB/Swiss-Prot:P32233

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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