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LOC127404488 H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:159894839-159895475 [ Homo sapiens (human) ]

Gene ID: 127404488, updated on 10-Oct-2023

Summary

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Gene symbol
LOC127404488
Gene description
H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:159894839-159895475
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay (MPRA) in primed human embryonic stem cells, where it is marked by the H3K27ac and H3K4me1 histone modifications. This locus also includes two accessible chromatin subregions that were validated as enhancers based on their ability to activate an origin of replication minimal core promoter by the ATAC-STARR-seq (assay for transposase-accessible chromatin with self-transcribing active regulatory region sequencing) MPRA in GM12878 lymphoblastoid cells. [provided by RefSeq, May 2023]
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Genomic context

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Location:
chromosome: 5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (160467832..160468468)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (160996325..160996961)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene MPRA-validated peak5561 silencer Neighboring gene SLU7 homolog, splicing factor Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23560 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23561 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23562 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16584 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16585 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:159849111-159849667 Neighboring gene PTTG1 regulator of sister chromatid separation, securin Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23563 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23564 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23565 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16586 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23566 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23567 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:159894202-159894838 Neighboring gene MIR3142 host gene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:159904496-159905044 Neighboring gene microRNA 3142 Neighboring gene microRNA 146a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ATAC-STARR-seq reveals transcription factor-bound activators and silencers across the chromatin accessible human genome. Hansen TJ, et al. Genome Res, 2022 Jul 20. PMID 35858748, Free PMC Article
  2. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

General gene information

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Other Names

  • ATAC-STARR-seq lymphoblastoid active region 23568
  • ATAC-STARR-seq lymphoblastoid active region 23569

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_106437.1 

    Range
    101..737
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    160467832..160468468
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    160996325..160996961
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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