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CNR2 cannabinoid receptor 2 [ Homo sapiens (human) ]

Gene ID: 1269, updated on 2-Nov-2024

Summary

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Official Symbol
CNR2provided by HGNC
Official Full Name
cannabinoid receptor 2provided by HGNC
Primary source
HGNC:HGNC:2160
See related
Ensembl:ENSG00000188822 MIM:605051; AllianceGenome:HGNC:2160
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CB2; CX5; CB-2
Summary
The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. The proteins encoded by this gene and the cannabinoid receptor 1 (brain) (CNR1) gene have the characteristics of a guanine nucleotide-binding protein (G-protein)-coupled receptor for cannabinoids. They inhibit adenylate cyclase activity in a dose-dependent, stereoselective, and pertussis toxin-sensitive manner. These proteins have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. The cannabinoid receptors are members of family 1 of the G-protein-coupled receptors. [provided by RefSeq, Jul 2008]
Expression
Biased expression in lymph node (RPKM 3.7), spleen (RPKM 3.4) and 4 other tissues See more
Orthologs
mouse all
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Genomic context

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See CNR2 in Genome Data Viewer
Location:
1p36.11
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (23870515..23913362, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (23705612..23750778, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (24197005..24239852, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376861 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:24151920-24152788 Neighboring gene alpha-L-fucosidase 1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:24191742-24192941 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 427 Neighboring gene uncharacterized LOC124904841 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 378 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 379 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 381 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 380 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 382 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 428 Neighboring gene BTB domain containing 6 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 383 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:24239664-24240178 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 384 Neighboring gene microRNA 378f Neighboring gene uncharacterized LOC124903877 Neighboring gene H3 histone pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cannabinoid receptor 2 plays a key role in renal fibrosis through inhibiting lipid metabolism in renal tubular cells.
    Title: Cannabinoid receptor 2 plays a key role in renal fibrosis through inhibiting lipid metabolism in renal tubular cells.
  2. Single nucleotide polymorphisms in the cannabinoid CB2 receptor: Molecular pharmacology and disease associations.
    Title: Single nucleotide polymorphisms in the cannabinoid CB(2) receptor: Molecular pharmacology and disease associations.
  3. Cannabinoid receptor 2 as a regulator of inflammation induced oleoylethanolamide in eosinophilic asthma.
    Title: Cannabinoid receptor 2 as a regulator of inflammation induced oleoylethanolamide in eosinophilic asthma.
  4. Roles of cannabinoid CB1 and CB2 receptors in the modulation of psychostimulant responses.
    Title: Roles of cannabinoid CB1 and CB2 receptors in the modulation of psychostimulant responses.
  5. CB2 Cannabinoid Receptor as a Potential Target in Myocardial Infarction: Exploration of Molecular Pathogenesis and Therapeutic Strategies.
    Title: CB2 Cannabinoid Receptor as a Potential Target in Myocardial Infarction: Exploration of Molecular Pathogenesis and Therapeutic Strategies.
  6. The clinical and pathological significance of increased expression of the cannabinoid receptors CB-1R and CB-2R in patients with papillary thyroid carcinomas compared to benign thyroid lesions.
    Title: The clinical and pathological significance of increased expression of the cannabinoid receptors CB-1R and CB-2R in patients with papillary thyroid carcinomas compared to benign thyroid lesions.
  7. Neuroprotection and Beyond: The Central Role of CB1 and CB2 Receptors in Stroke Recovery.
    Title: Neuroprotection and Beyond: The Central Role of CB1 and CB2 Receptors in Stroke Recovery.
  8. Tumor necrosis factor alpha, and agonist and antagonists of cannabinoid receptor type 1 and type 2 alter the immunophenotype of stem cells from human exfoliated deciduous teeth.
    Title: Tumor necrosis factor α, and agonist and antagonists of cannabinoid receptor type 1 and type 2 alter the immunophenotype of stem cells from human exfoliated deciduous teeth.
  9. Overexpression of cannabinoid receptor 2 is associated with human breast cancer proliferation, apoptosis, chemosensitivity and prognosis via the PI3K/Akt/mTOR signaling pathway.
    Title: Overexpression of cannabinoid receptor 2 is associated with human breast cancer proliferation, apoptosis, chemosensitivity and prognosis via the PI3K/Akt/mTOR signaling pathway.
  10. Cannabinoid receptor 2 alleviates sepsis-associated acute lung injury by modulating maturation of dendritic cells.
    Title: Cannabinoid receptor 2 alleviates sepsis-associated acute lung injury by modulating maturation of dendritic cells.
Submit: New GeneRIF Correction See all GeneRIFs (244)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Upregulation of the human proteins CCL2, CX3CL1, IL-1beta, and CXCL10 by HIV-1 gp120 involves CB2 receptor in mesencephalic neuronal/glial culture model PubMed
env CB1 or CB2 receptor agonists significantly inhibit HIV-1 gp120-induced decrease proliferation and increase apoptosis of human neural progenitor cells (hNPCs), indicating that CB1 or CB2 receptors are required for the effects of gp120 on hNPCs PubMed
env HIV-1 gp120-induced synapse loss is inhibited by activation of CB2 receptor PubMed
Tat tat CB1 and CB2 endocannabinoid receptors are involved in HIV-1 Tat-induced cleavage of PARP1 and CASP3 in retinal cells PubMed
tat Treatment with cannabinoids inhibits HIV-1 Tat-enhanced attachment of U937 cells to collagen IV, laminin, or ECM1 proteins, which is linked to the cannabinoid receptor type 2 and the modulation of beta1-integrin and actin distribution PubMed
tat HIV-1 Tat upregulates the expression of CB1 and CB2 cannabinoid receptors in retinal cells, which is suppressed by endocannabinoids, N-arachidonoylethanolamide and 2-arachidonoylglycerol PubMed
tat CB(2) cannabinoid receptor 2 is involved in HIV-1 Tat-mediated macrophage migration PubMed
tat HIV-1 Tat-mediated activation of the CB2R leads to altered expression and compartmentation of the beta-chemokine receptor CCR-3 PubMed
capsid gag Monocyte-derived macrophages treated during differentiation with a CB2 specific agonist show decrease in p24 levels PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cannabinoid receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS
Traceable Author Statement
more info
 PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cannabinoid signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in immune response TAS
Traceable Author Statement
more info
 PubMed 
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
  
involved_in leukocyte chemotaxis IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of action potential IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of mast cell activation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of synaptic transmission, GABAergic IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to amphetamine IEA
Inferred from Electronic Annotation
more info
  
involved_in response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
  
involved_in trans-synaptic signaling by endocannabinoid, modulating synaptic transmission IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extrinsic component of cytoplasmic side of plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cannabinoid receptor 2
Names
cannabinoid receptor 2 (macrophage)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001841.3 → NP_001832.1  cannabinoid receptor 2

    See identical proteins and their annotated locations for NP_001832.1

    Status: REVIEWED

    Source sequence(s)
    AL590609, BC069722, X74328
    Consensus CDS
    CCDS245.1
    UniProtKB/Swiss-Prot
    C6ES44, P34972, Q4VBK8, Q5JRH7, Q6B0G7, Q6NSY0
    Related
    ENSP00000363596.4, ENST00000374472.5
    Conserved Domains (1) summary
    cd15341
    Location:34 → 310
    7tmA_CB2; cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    23870515..23913362 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011540629.4 → XP_011538931.1  cannabinoid receptor 2 isoform X1

    See identical proteins and their annotated locations for XP_011538931.1

    UniProtKB/Swiss-Prot
    C6ES44, P34972, Q4VBK8, Q5JRH7, Q6B0G7, Q6NSY0
    Conserved Domains (1) summary
    cd15341
    Location:34 → 310
    7tmA_CB2; cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. XM_047444833.1 → XP_047300789.1  cannabinoid receptor 2 isoform X1

    UniProtKB/Swiss-Prot
    C6ES44, P34972, Q4VBK8, Q5JRH7, Q6B0G7, Q6NSY0

  3. XM_017000261.3 → XP_016855750.1  cannabinoid receptor 2 isoform X1

    UniProtKB/Swiss-Prot
    C6ES44, P34972, Q4VBK8, Q5JRH7, Q6B0G7, Q6NSY0
    Conserved Domains (1) summary
    cd15341
    Location:34 → 310
    7tmA_CB2; cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    23705612..23750778 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054334280.1 → XP_054190255.1  cannabinoid receptor 2 isoform X1

  2. XM_054334279.1 → XP_054190254.1  cannabinoid receptor 2 isoform X1

  3. XM_054334278.1 → XP_054190253.1  cannabinoid receptor 2 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P34972.1 GenPept UniProtKB/Swiss-Prot:P34972

Gene LinkOut

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