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KIT KIT proto-oncogene, receptor tyrosine kinase [ Vulpes lagopus (Arctic fox) ]

Gene ID: 121473772, updated on 22-Mar-2024

Summary

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Gene symbol
KIT
Gene description
KIT proto-oncogene, receptor tyrosine kinase
Gene type
protein coding
RefSeq status
MODEL
Organism
Vulpes lagopus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes
Also known as
c-kit
Orthologs
human mouse all
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Genomic context

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See KIT in Genome Data Viewer
Location:
chromosome: 12
Exon count:
21
Annotation release Status Assembly Chr Location
100 current ASM1834538v1 (GCF_018345385.1) 12 NC_054835.1 (69187489..69270919)

Chromosome 12 - NC_054835.1Genomic Context describing neighboring genes Neighboring gene GS homeobox 2 Neighboring gene platelet derived growth factor receptor alpha Neighboring gene uncharacterized LOC121473799 Neighboring gene uncharacterized LOC121472520

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_054835.1 Chromosome 12 Reference ASM1834538v1 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A base substitution in the donor site of intron 12 of KIT gene is responsible for the dominant white coat colour of blue fox (Alopex lagopus). Yan SQ, et al. Anim Genet, 2014 Apr. PMID 24308634
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cytokine binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in B cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in Fc receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in Kit signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of MAP kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of receptor signaling pathway via JAK-STAT IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
mast/stem cell growth factor receptor Kit
Names
mast/stem cell growth factor receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Vulpes lagopus Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM1834538v1 Primary Assembly

Genomic

  1. NC_054835.1 Reference ASM1834538v1 Primary Assembly

    Range
    69187489..69270919
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_041726464.1 → XP_041582398.1  mast/stem cell growth factor receptor Kit isoform X1

    Conserved Domains (2) summary
    smart00409
    Location:224 → 308
    IG; Immunoglobulin
    cd05104
    Location:554 → 929
    PTKc_Kit; Catalytic domain of the Protein Tyrosine Kinase, Kit

  2. XM_041726468.1 → XP_041582402.1  mast/stem cell growth factor receptor Kit isoform X5

    Conserved Domains (2) summary
    smart00409
    Location:224 → 308
    IG; Immunoglobulin
    cl21453
    Location:554 → 894
    PKc_like; Protein Kinases, catalytic domain

  3. XM_041726466.1 → XP_041582400.1  mast/stem cell growth factor receptor Kit isoform X3

    Conserved Domains (5) summary
    cd05104
    Location:550 → 925
    PTKc_Kit; Catalytic domain of the Protein Tyrosine Kinase, Kit
    pfam00047
    Location:216 → 306
    ig; Immunoglobulin domain
    pfam13927
    Location:413 → 496
    Ig_3; Immunoglobulin domain
    cd00096
    Location:268 → 278
    Ig; Ig strand E [structural motif]
    cd05860
    Location:312 → 412
    IgI_4_SCFR; Fourth immunoglobulin (Ig)-like domain of stem cell factor receptor (SCFR); member of the I-set of IgSF domains

  4. XM_041726465.1 → XP_041582399.1  mast/stem cell growth factor receptor Kit isoform X2

    Conserved Domains (2) summary
    smart00409
    Location:224 → 307
    IG; Immunoglobulin
    cd05104
    Location:553 → 928
    PTKc_Kit; Catalytic domain of the Protein Tyrosine Kinase, Kit

  5. XM_041726467.1 → XP_041582401.1  mast/stem cell growth factor receptor Kit isoform X4

    UniProtKB/TrEMBL
    U5LL56
    Conserved Domains (5) summary
    cd05104
    Location:549 → 924
    PTKc_Kit; Catalytic domain of the Protein Tyrosine Kinase, Kit
    pfam00047
    Location:216 → 305
    ig; Immunoglobulin domain
    pfam13927
    Location:412 → 495
    Ig_3; Immunoglobulin domain
    cd00096
    Location:286 → 294
    Ig; Ig strand F [structural motif]
    cd05860
    Location:311 → 411
    IgI_4_SCFR; Fourth immunoglobulin (Ig)-like domain of stem cell factor receptor (SCFR); member of the I-set of IgSF domains
Nucleotide Protein Strain
Heading Accession and Version

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